UNASSIGNED: Schizophrenia is often associated with volumetric reductions in cortices and expansions in basal ganglia, particularly the putamen. Recent genome-wide association studies have highlighted the significance of variants in the 3\' regulatory region adjacent to the kinectin 1 gene (KTN1) in regulating gray matter volume (GMV) of the putamen. This study aimed to comprehensively investigate the involvement of this region in schizophrenia.
UNASSIGNED: We analyzed 1136 single-nucleotide polymorphisms (SNPs) covering the entire 3\' regulatory region in 4 independent dbGaP samples (4604 schizophrenia patients vs. 4884 healthy subjects) and 3 independent Psychiatric Genomics Consortium samples (107 240 cases vs. 210 203 controls) to identify consistent associations. Additionally, we examined the regulatory effects of schizophrenia-associated alleles on KTN1 mRNA expression in 16 brain areas among 348 subjects, as well as GMVs of 7 subcortical nuclei in 38 258 subjects, and surface areas (SA) and thickness (TH) of the entire cortex and 34 cortical areas in 36 936 subjects.
UNASSIGNED: The major alleles (f > 0.5) of 25 variants increased (β > 0) the risk of schizophrenia across 2 to 5 independent samples (8.4 × 10-4 ≤ P ≤ .049). These schizophrenia-associated alleles significantly elevated (β > 0) GMVs of basal ganglia, including the putamen (6.0 × 10-11 ≤ P ≤ 1.1 × 10-4), caudate (8.7 × 10-4 ≤ P ≤ 9.4 × 10-3), pallidum (P = 6.0 × 10-4), and nucleus accumbens (P = 2.7 × 10-5). Moreover, they potentially augmented (β > 0) the SA of posterior cingulate and insular cortices, as well as the TH of frontal (pars triangularis and medial orbitofrontal), parietal (superior, precuneus, and inferior), and temporal (transverse) cortices, but potentially reduced (β < 0) the SA of the whole, frontal (medial orbitofrontal), and temporal (pole, superior, middle, and entorhinal) cortices, as well as the TH of rostral middle frontal and superior frontal cortices (8.9 × 10-4 ≤ P ≤ .050).
UNASSIGNED: Our findings identify significant and functionally relevant risk alleles in the 3\' regulatory region adjacent to KTN1, implicating their crucial roles in the development of schizophrenia.

Due to the optical properties of the electron transport layer (ETL) and hole transport layer (HTL), inverted perovskite solar cells can perform better than traditional perovskite solar cells. It is essential to compare both types to understand their efficiencies. In this article, we studied inverted perovskite solar cells with NiOx/CH3NH3Pb3/ETL (ETL = MoO3, TiO2, ZnO) structures. Our results showed that the optimal thickness of NiOx is 80 nm for all structures. The optimal perovskite thickness is 600 nm for solar cells with ZnO and MoO3, and 800 nm for those with TiO2. For the ETLs, the best thicknesses are 100 nm for ZnO, 80 nm for MoO3, and 60 nm for TiO2. We found that the efficiencies of inverted perovskite solar cells with ZnO, MoO3, and TiO2 as ETLs, and with optimal layer thicknesses, are 30.16%, 18.69%, and 35.21%, respectively. These efficiencies are 1.5%, 5.7%, and 1.5% higher than those of traditional perovskite solar cells. Our study highlights the potential of optimizing layer thicknesses in inverted perovskite solar cells to achieve higher efficiencies than traditional structures.

In-depth mechanical characterization of veins is required for promising innovations of venous substitutes and for better understanding of venous diseases. Two important physical parameters of veins are shape and thickness, which are quite challenging in soft tissues. Here, we propose the method TREE (TransfeR learning-based approach for thicknEss Estimation) to predict both the segmentation map and thickness value of the veins. This model incorporates one encoder and two decoders which are trained in a special manner to facilitate transfer learning. First, an encoder-decoder pair is trained to predict segmentation maps, then this pre-trained encoder with frozen weights is paired with a second decoder that is specifically trained to predict thickness maps. This leverages the global information gained from the segmentation model to facilitate the precise learning of the thickness model. Additionally, to improve the performance we introduce a sensitive pattern detector (SPD) module which further guides the network by extracting semantic details. The swept-source optical coherence tomography (SS-OCT) is the imaging modality for saphenous varicose vein extracted from the diseased patients. To demonstrate the performance of the model, we calculated the segmentation accuracy-0.993, mean square error in thickness (pixels) estimation-2.409 and both these metrics stand out when compared with the state-of-art methods.

Introduction Diabetes mellitus (DM) is a multifaceted metabolic disorder distinguished by elevated blood sugar levels. Type 2-DM (T2DM) stands as a significant contributor to disability due to its widespread occurrence of microvascular and macrovascular complications. According to certain researchers, prolonged elevated blood sugar levels have been observed to trigger a sequence of irregular alterations in the Achilles tendon (AT). AT thickness is one such indicator of these alterations. Methods This was a prospective study carried out on 51 individuals which was further divided into 3 groups (Group A - Normal individuals, Group B - DM without foot complications, Group C - DM with foot complications) with 17 individuals in each as healthy, DM with foot complications and without complications at Sri Devaraj Urs Medical College over a period of one year. The patients\' demographics, basic medical records, and laboratory test results were examined and analyzed. Results The mean age of the study participants was 55.41 + 10.25 years. There was no significant difference in age and gender between the three groups. There was a significant difference in mean AT thickness between the groups (p<0.05). The mean thickness of AT was higher in Group C compared to Group B. Group A had the least AT thickness. However, there was no correlation between the variables in individual groups. Conclusions Modifications in the AT\'s structure may occur before the onset of foot and ankle issues in individuals with diabetes. Hence, the thickening of the AT can be used as an early indicator of impending diabetic foot complications.

UNASSIGNED: Translucency and optical characteristics significantly affect the aesthetics of ceramic restorations. The introduction of new virgilite crystals to novel ceramic advanced lithium disilicate through a matrix firing process enhances the material\'s strength and aesthetic quality according to the manufacturer.
UNASSIGNED: Four types of CAD/CAM ceramics; lithium disilicate (LD), leucite reinforced (LR), advanced lithium disilicate (ALD), and zirconia-reinforced lithium silicate (ZLS) exposed to different staining solutions (tea, cola, coffee, and distilled water). Each ceramic type had 120 specimens, divided into subgroups based on thickness (0.5 mm, 1 mm, and 1.5 mm). Color changes (ΔE00) and translucency parameters (TP00) were measured after thermocycling, and spectrophotometry was employed to evaluate ΔE00 and TP00 after 1, 7, and 30 days of exposure to the staining solutions.
UNASSIGNED: ZLS exhibited the lowest color stability, while lithium LD and ALD displayed the highest. Thickness significantly affected color stability, with 0.5 mm thickness showing the least change. The duration of exposure also impacted color changes, with 30 days causing the most significant shift. LD demonstrated the highest translucency. Coffee and tea induced more pronounced reductions in translucency and color stability compared to the control group.
UNASSIGNED: Material structure, thickness, staining solution, and exposure duration significantly influenced the color stability and translucency of CAD/CAM ceramics, with LD and ALD demonstrating superior color stability and LD exhibiting the highest translucency.

For Ni-YSZ anode-supported solid oxide fuel cells (SOFCs), the main drawback is that they are susceptible to reducing and oxidizing atmosphere changes because of the Ni/NiO volume variation. The anode expansion upon oxidation can cause significant stresses in the cell, eventually leading to failure. In order to improve the redox stability, an analytical model is developed to study the effect of anode structure on redox stability. Compared with the SOFC without AFL, the tensile stresses in the electrolyte and cathode of SOFC with an anode functional layer (AFL) after anode oxidation are increased by 27.07% and 20.77%, respectively. The thickness of the anode structure has a great influence on the structure\'s stability. Therefore, the influence of anode thickness and AFL thickness on the stress in these two structures after oxidation is also discussed. The thickness of the anode substrate plays a more important role in the SOFC without AFL than in the SOFC with AFL. By increasing the thickness of the anode substrate, the stresses in the electrolyte and cathode decrease. This method provides a theoretical basis for the design of a reliable SOFC in the redox condition and will be more reliable with more experimental proofs in the future.

UNASSIGNED: The objective of this study was to investigate the biomechanical effects of different tooth movement patterns and aligner thicknesses on teeth and periodontal tissues during maxillary arch expansion with clear aligners, to facilitate more precise and efficient clinical orthodontic treatments.
UNASSIGNED: Three-dimensional models including teeth, maxilla, periodontal ligament, and aligner were constructed and subjected to finite element analysis. Tooth displacement trends and periodontal ligament stresses were measured for seven tooth displacement patterns (divided into three categories including overall movement of premolars and molars with gradually increasing molar expansion in each step; distributed movement of premolars and molars; and alternating movement between premolars and molars at intervals) and two aligner thicknesses (0.5 mm and 0.75 mm) during maxillary arch expansion with clear aligners.
UNASSIGNED: When expanding the maxillary arch with clear aligners, the effective expansion of the target teeth mainly showed a tilting movement trend. Increasing the amount of molar expansion increased the buccal displacement of the first molar but decreased the buccal displacement of the premolars. The mean buccal displacement of the target teeth was greater in the posterior teeth interval alternating movement group (0.026 mm) than in the premolar/molar distributed movement group (0.016 mm) and the overall movement group (0.015 mm). Increasing aligner thickness resulted in greater buccal displacement of the crowns and increased stress on the periodontal ligaments.
UNASSIGNED: Increasing the amount of molar expansion reduces the efficiency of premolar expansion. Alternating movement of premolars and molars at intervals achieves a higher arch expansion efficiency, but attention should be paid to the anchorage of adjacent teeth. Increasing the thickness of the aligner increases the expansion efficiency but may also increase the burden on the periodontal tissues.

BACKGROUND: Effects of ceramic translucency, layer thickness, and substrate colour on the shade of lithium disilicate glass-ceramic restorations proved to be significant in several studies, however, quantitative, numerical results on the relationship between the colour difference and these parameters are still lacking. The purpose of this in vitro study was to quantitatively determine how the colour reproduction ability of a lithium disilicate glass-ceramic is affected by its translucency, layer thickness, and substrate colour.
METHODS: Ceramic samples were prepared from A2 shade IPS e.max CAD blocks with high and low translucencies (HT and LT) in a thickness range of 0.5-2.5 mm (+/- 0.05 mm). Layered samples were acquired utilizing composite substrates in 9 shades; transparent try-in paste was used. The spectral reflectance of the specimens was assessed under D65 standard illumination with a Konica Minolta CM-3720d spectrophotometer. The CIEDE2000 colour difference (ΔE00) between two samples was analysed using perceptibility and acceptability thresholds set at 50:50%. Statistical analysis involved linear regression analysis and the Kruskal-Wallis test.
RESULTS: An increase in the thickness of 0.5 mm reduced the ΔE00 of the HT samples to 72.8%, and that of the T samples to 71.1% (p < 0.0001). 7 substrates with HT and LT specimens had significantly different results from the mean (p < 0.05). A thickness of 0.5 mm is not sufficient to achieve an acceptable result at any level of translucency, while the low translucency ceramic at a thickness of 1.5 mm gave acceptable results, except for severely discoloured substrates (ND8 and ND9).
CONCLUSIONS: The colour reproduction ability of lithium disilicate glass-ceramics is significantly affected by their translucency, layer thickness, and 7 substrates out of 9 substrates examined.

UNASSIGNED: Activation of the trigeminal vascular system in migraine releases vasoactive neurotransmitters, causing abnormal vasoconstriction, which may affect the ocular system, leading to retinal damage. The purpose of our study was to determine whether there are differences in each retinal layer between migraine patients and healthy subjects.
UNASSIGNED: A case-control study recruited 38 migraine patients and 38 age- and sex-matched controls. Optical coherence tomography was used to measure the thickness of the peripapillary and macular retinal nerve fiber layer (pRNFL and mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and inner nuclear layer (INL).
UNASSIGNED: The mean ages of the migraine patients and controls were 36.29 ± 9.45 and 36.45 ± 9.27 years, respectively. Thirty-four patients (89.48%) in both groups were female. The mean disability score was 19.63 ± 20.44 (indicating severe disability). The superior-outer INL of migraine patients were thicker than controls. Thickness of the GCL at temporal-outer sector and mRNFL at the superior-outer sector of the headache-side eyes was reduced. However, the INL of the headache-side-eye showed negative correlation with the disability score. This is the first study having found thinning of the GCL and mRNFL of the headache-side eyes. The INL was also thickened in migraines but showed negative correlation with the disability score.
UNASSIGNED: Increased INL thickness in migraine patients may result from inflammation. The more severe cases with a high disability score might suffered progressive retinal neuronal loss, resulting in thinner INL than less severe cases.

This research paper intends to numerically investigate the impact of selected factors on the strength of the concrete overlay-bridge deck bond, directly and indirectly, using the nonlinear finite element analysis (NLFEA) method. Besides, the research introduces the guidelines necessary to attain adequate bond strength to eliminate the possibility of concrete detachment under the effect of different developed stresses. The NLFEA has been utilized in predicting and correlating the live applied loads and the induced shrinkage stresses at the interfacial region between the concrete overlay and the bridge deck. The developed stresses were related to the overlay\'s direct tensile bond strength. A total of 336 NLFEA models of overlay-bridge deck slab segments were designed and examined after being properly validated. The parameters of the study were as follows: the overlay degradation level (0 %, 19 %, 36 %, 51 %, 64 %, and 75 %); the ratio of the overlay\'s relative thickness-to-the bridge deck slab (toverlay/tslab); in addition to the age of the shrinkage induced stresses (early age (3 and 7 days) and moderate age (14 and 28 days)). The NLFEA live load and shrinkage stress values were validated using experimental results from the literature with difference percentages of less than 5 %. The numerical study results recommended that the thickness of the concrete\'s overlay should be within certain overlay thickness limits to be capable of handling the lower and higher stresses at the service and overloading conditions. The proposed guidelines enable the avoidance of unfavorable detachment between the interface parts under the effect of AASHTO HS-20 truck cyclic and impact loadings, as well as shrinkage loading.