铜具有几种临床相关的放射性同位素和多功能配位化学,允许其放射性核素附着到生物分子上。该特性使其适合在分子成像或放射性核素靶向治疗中的应用。当今核医学特别感兴趣的是治疗方法。这篇简短的评论考虑了五种铜放射性核素。这些是Cu-60、Cu-61、Cu-62、Cu-64和Cu-67。前四个是用于成像的正电子发射器,最后一种Cu-67是一种β-发射放射性核素,适用于靶向治疗。这里的重点是对可用实验数据进行理论辅助评估,以期建立标准化的横截面数据库,以生产高纯度的相关放射性核素。已经广泛报道了正电子发射体的评估横截面数据;因此在这里仅简要回顾它们。更多关注68Zn的数据(p,2p)67Cu中间能反应,通常用于生产67Cu。
Copper has several clinically relevant radioisotopes and versatile coordination chemistry, allowing attachment of its radionuclides to biological molecules. This characteristic makes it suitable for applications in molecular imaging or radionuclide targeted therapy. Of particular interest in nuclear medicine today is the theranostic approach. This brief review considers five radionuclides of copper. These are Cu-60, Cu-61, Cu-62, Cu-64, and Cu-67. The first four are positron emitters for imaging, and the last one Cu-67 is a β--emitting radionuclide suitable for targeted therapy. The emphasis here is on theory-aided evaluation of available experimental data with a view to establishing standardised cross-section database for production of the relevant radionuclide in high purity. Evaluated cross section data of the positron emitters have been already extensively reported; so here they are only briefly reviewed. More attention is given to the data of the 68Zn(p,2p)67Cu intermediate energy reaction which is rather commonly used for production of 67Cu.