Repetitive workplace tasks are associated with fatigue-induced changes to shoulder muscular strategies, potentially altering kinematics and elevating susceptibility to tissue overexposures. Accessible and reliable methods to detect shoulder muscle fatigue in the workplace are therefore valuable. Detectable changes in joint motion may provide a plausible fatigue identification method. In this investigation, the onset of the first kinematic changes, as identified by a symbolic motion representation (SMSR) algorithm, and the onset of substantial surface electromyography (sEMG) mean power frequency (MPF) fatigue were not significantly different, both occurring around 10% of task duration. This highlights the potential utility of SMSR identified directional changes in joint motion during repetitive tasks as a cue of substantial muscle fatigue, enabling ergonomics responses that can mitigate shoulder muscular fatigue accumulation and its associated deleterious physical effects. Practitioner Summary: The onset of substantial muscle fatigue during a repetitive dynamic task was assessed using kinematics and myoelectric-based techniques. Algorithmically detectable directional changes in upper extremity joint motion occurred with the onset of substantial muscle fatigue, highlighting the potential of this as a useful approach for workplace fatigue identification.