未经证实:系统性红斑狼疮(SLE)可显著影响患者的生活质量和主观幸福感(SWB),但是临床特征之间的关系,SWB,相关的心理因素研究甚少。
未经批准:为了测量SLE患者的SWB,并检查主要的临床决定因素,情绪变量,相关的积极因素影响SWB。
未经评估:总的来说,来自中国SLE治疗和研究组(CSTAR)的1,110例SLE患者和来自没有自我报告SLE的普通人群的198例年龄和性别匹配的个体被邀请完成由生活满意度量表(SWLS)评估的SWB问卷。通过患者健康问卷-9(PHQ-9)评估的情绪变量,和一般焦虑障碍-7(GAD-7)和相关的积极因素通过自尊量表(SES)评估,一般自我效能感量表(GESE),和康纳-戴维森弹性量表(CD-RISC)。采用多元线性回归分析临床表现与SWB之间的关系。
UNASSIGNED:SLE患者的生活满意度明显低于一般人群(p<0.001)。积极皮肤受累(OR=0.923,95%CI=0.868-0.981,p<0.05)与生活满意度评分呈负相关,在多元回归模型中,与生活满意度评分呈正相关(OR=1.160,95%CI=1.092-1.230,p<0.001).累积器官损害与抑郁(OR=1.085,95%CI=1.022-1.153,p<0.01)和自尊丧失(OR=1.067,95%CI=1.004-1.133,p<0.05)显著相关。
UNASSIGNED:SWB为SLE对心理健康的影响以及改善生活质量和临床护理的机会提供了有用的见解。
UNASSIGNED: Systemic lupus erythematosus (SLE) can significantly influence patients\' quality of life and subjective well-being (SWB), but the relationships between clinical characteristics, SWB, and related psychological factors have been little studied.
UNASSIGNED: To measure SWB in patients with SLE and examine how major clinical determinants, emotional variables, and related positive factors affect SWB.
UNASSIGNED: Overall, 1,110 patients with SLE from the Chinese SLE Treatment and Research Group (CSTAR) and 198 age and gender-matched individuals from the general population without self-reported SLE were invited to complete questionnaires of SWB evaluated by the satisfaction with life scale (SWLS), emotional variables assessed by the patient health questionnaire-9 (PHQ-9), and general anxiety disorder-7 (GAD-7) and related positive factors assessed by the self-esteem scale (SES), general self-efficacy scale (GESE), and Connor-Davidson resilience scale (CD-RISC). The multivariate linear regression was used to examine the relationship between clinical manifestations and SWB.
UNASSIGNED: Life satisfaction was significantly lower (p < 0.001) in patients with SLE than in the general population. Active skin involvement (OR = 0.923, 95% CI = 0.868-0.981, p < 0.05) was negatively associated with life satisfaction scores, and age at enrollment (OR = 1.160, 95% CI = 1.092-1.230, p < 0.001) were positively associated with life satisfaction scores in the multivariate regression model. The cumulative organ damage was significantly associated with depression (OR = 1.085, 95% CI = 1.022-1.153, p < 0.01) and the loss of self-esteem (OR = 1.067, 95% CI = 1.004-1.133, p < 0.05).
UNASSIGNED: SWB provides useful insight into the impact of SLE on psychological health and opportunities to improve quality of life and clinical care.