■Esketamine具有麻醉和镇痛性能。本研究旨在观察亚麻醉剂量(0.15~0.3mg/kg/h)右美托咪定和瑞芬太尼在吸脂术麻醉中的增强作用。
■总共155名受试者以1:1的比例随机分配到E组(艾氯胺酮-右美托咪定/瑞芬太尼,n=78)或C组(盐水-右美托咪定/瑞芬太尼组,n=77)。主要结果是患者和手术团队对手术的满意度。次要结果是术后雅典失眠量表(AIS)和医院焦虑抑郁量表(HADS)评分,血液动力学和呼吸变化,药物消费,不良事件发生率,以及与患者满意度相关的预测因素。
■E组患者和手术团队对手术的满意度明显高于C组(4.7±0.6vs4.2±0.7,P<0.001;4.7±0.5vs4.4±0.7,P=0.005)。术后AIS(4[1,6]vs5[2,9],P=0.012)和HADS-A(1[0,3]vs2[0,6],P=0.012)评分E组明显低于C组,阿片类药物的舒芬太尼消费量较低(0[0,4]对5[2.5,7.7],P<0.001)和瑞芬太尼(700[480,900]vs800[500,1200],与C组相比,E组的P=0.023)。在顺序物流回归上,术后睡眠质量(OR,0.70;95%CI,0.62-0.79),焦虑水平(或,0.77;95%CI,0.62-0.95)和麻醉后监护病房(PACU)的恢复时间(OR,0.69;95%CI,0.56-0.98)被确定为与患者满意度相关的显著预测因子。
■亚麻醉剂量的艾氯胺酮(0.15-0.3mg/kg/h)作为佐剂可改善右美托咪定和瑞芬太尼在吸脂手术麻醉期间的镇静和镇痛作用。
■ChiCTR2400080363。
UNASSIGNED: Esketamine have anesthetic and analgesic properties. This study aimed to observe the enhancing effect of subanesthetic doses of esketamine (0.15-0.3 mg/kg/h) with dexmedetomidine and remifentanil during anesthesia for liposuction surgery.
UNASSIGNED: A total of 155 subjects were randomized with a 1:1 ratio to Group E (esketamine-dexmedetomidine/remifentanil, n=78) or Group C (saline-dexmedetomidine/remifentanil group, n=77). The primary outcome was satisfaction of patient and surgical team with the procedure. The secondary outcomes were the postoperative Athens Insomnia Scale (AIS) and Hospital Anxiety and Depression Scale (HADS) scores, hemodynamic and respiratory changes, drug consumption, adverse event rates, and predictors associated with patient satisfaction.
UNASSIGNED: Patient and surgical team satisfaction with the procedure was significantly higher in Group E than in Group C (4.7 ± 0.6 vs 4.2 ± 0.7, P < 0.001; 4.7 ± 0.5 vs 4.4 ± 0.7, P = 0.005). The postoperative AIS (4 [1, 6] vs 5 [2, 9], P = 0.012) and HADS-A (1 [0, 3] vs 2 [0, 6], P = 0.012) scores were significantly lower in Group E than in Group C. Hemodynamic and respiratory parameters were more stable in Group E than in Group C, with the lower opioids consumption of sufentanil (0 [0, 4] vs 5 [2.5, 7.7], P < 0.001) and remifentanil (700 [480, 900] vs 800 [500, 1200], P = 0.023) in Group E compared to Group C. On ordinal logistics regression, postoperative sleep quality (OR, 0.70; 95% CI, 0.62-0.79), anxiety level (OR, 0.77; 95% CI, 0.62-0.95) and recovery time in post-anesthesia care unit (PACU) (OR, 0.69; 95% CI, 0.56-0.98) were identified as significant predictors associated with patient satisfaction.
UNASSIGNED: A subanesthetic dose of esketamine (0.15-0.3 mg/kg/h) as an adjuvant can improves the sedative and analgesic effects of dexmedetomidine and remifentanil during anesthesia for liposuction surgery.
UNASSIGNED: ChiCTR2400080363.