■红细胞分布宽度(RDW)升高与一系列健康结果相关。本研究旨在检查RDW水平的预后和病因作用,表型和遗传易感性,在预测心血管结局时,糖尿病,慢性肾脏病(CKD)和死亡率。
■我们研究了来自马尔默饮食与癌症研究(MDCS)的27,141名中年人,平均随访21年。用血液学分析仪对全血样品测量RDW。使用MDCS中的遗传数据和从RDW的全基因组关联研究中发表的汇总统计数据,为每个参与者构建了RDW的多基因评分(PGS-RDW)(n=408,112)。Cox比例风险回归用于评估RDW,PGS-RDW和心血管结局,糖尿病,CKD与死亡率,分别。
■PGS-RDW与RDW显著相关(皮尔逊相关系数=0.133,p<0.001)。RDW与卒中发生率显着相关(每1个标准差的风险比(HR)=1.06,95%置信区间(CI):1.02-1.10,p=0.003),心房颤动(HR=1.09,95%CI:1.06-1.12,p<0.001),心力衰竭(HR=1.13,95%CI:1.08-1.19,p<0.001),静脉血栓栓塞(HR=1.21,95%CI:1.15-1.28,p<0.001),糖尿病(HR=0.87,95%CI:0.84-0.90,p<0.001),CKD(HR=1.08,95%CI:1.03-1.13,p=0.004)和全因死亡率(HR=1.18,95%CI:1.16-1.20,p<0.001)。然而,PGS-RDW与糖尿病发病率显著相关(HR=0.96,95%CI:0.94-0.99,p=0.01),但没有任何其他测试结果。
■RDW与心血管疾病的死亡率和发病率相关,但未观察到遗传决定的RDW与心血管疾病之间存在显著关联.然而,RDW和PGS-RDW均与糖尿病发病率呈负相关,暗示了一种推定的因果关系。与糖尿病发病的关系有待进一步研究。
UNASSIGNED: Elevated red cell distribution width (RDW) has been associated with a range of health outcomes. This study aims to examine prognostic and etiological roles of RDW levels, both phenotypic and genetic predisposition, in predicting cardiovascular outcomes, diabetes, chronic kidney disease (CKD) and mortality.
UNASSIGNED: We studied 27,141 middle-aged adults from the Malmö Diet and Cancer study (MDCS) with a mean follow up of 21 years.
RDW was measured with a hematology analyzer on whole blood samples. Polygenic scores for
RDW (PGS-
RDW) were constructed for each participant using genetic data in MDCS and published summary statistics from genome-wide association study of RDW (n = 408,112). Cox proportional hazards regression was used to assess associations between
RDW, PGS-
RDW and cardiovascular outcomes, diabetes, CKD and mortality, respectively.
UNASSIGNED: PGS-
RDW was significantly associated with
RDW (Pearson\'s correlation coefficient = 0.133, p < 0.001). RDW was significantly associated with incidence of stroke (hazard ratio (HR) per 1 standard deviation = 1.06, 95% confidence interval (CI): 1.02-1.10, p = 0.003), atrial fibrillation (HR = 1.09, 95% CI: 1.06-1.12, p < 0.001), heart failure (HR = 1.13, 95% CI: 1.08-1.19, p < 0.001), venous thromboembolism (HR = 1.21, 95% CI: 1.15-1.28, p < 0.001), diabetes (HR = 0.87, 95% CI: 0.84-0.90, p < 0.001), CKD (HR = 1.08, 95% CI: 1.03-1.13, p = 0.004) and all-cause mortality (HR = 1.18, 95% CI: 1.16-1.20, p < 0.001). However, PGS-RDW was significantly associated with incidence of diabetes (HR = 0.96, 95% CI: 0.94-0.99, p = 0.01), but not with any other tested outcomes.
UNASSIGNED: RDW is associated with mortality and incidence of cardiovascular diseases, but a significant association between genetically determined RDW and incident cardiovascular diseases were not observed. However, both
RDW and PGS-
RDW were inversely associated with incidence of diabetes, suggesting a putative causal relationship. The relationship with incidence of diabetes needs to be further studied.