目的:肺胎盘移位(PT)是一种良性病变,可通过切除术治愈,表现为异常的特殊形态变化,包括肺错构瘤中的胎盘样大疱性变化。在这项回顾性研究中,我们的目的是检查肺错构瘤的组织病理学特征,为了评估不同的组织学成分,尤其是PT,并探讨PT模式的重要性及其与其他临床病理特征的关系。
方法:从2001年至2021年的记录中招募35例肺错构瘤,根据PT的存在分为两组,病理检查为PT(-)和PT(+)。
结果:所有患者中77.1%为男性。两组在年龄方面无显著差异,性别,合并症,存在的症状,肿瘤定位,放射学检查结果(P>0.05)。28例(80%)患者全部切除肺错构瘤。其中5例(17.9%)切除材料中存在不同程度的PT成分,在5%至80%之间,都是男性患者。在15名PT(-)和5名PT()患者中进行了冰冻切片检查,但在任何PT()患者中均未达到冰冻切片的诊断。两组材料中大部分为软骨样成分(52.22±29.7%)(P<0.05)。
结论:胎盘乳头状突起是与肺错构瘤相关的可用模式,特别是在冰冻切片中观察到的这些突起对于识别错构瘤的PT模式非常关键,因为它们会导致恶性肿瘤鉴别诊断的混淆。
OBJECTIVE: Pulmonary placental transmogrification (PT) is a benign lesion curable by resection, represented by an unusual peculiar morphological variation including placentoid bullous change in the pulmonary hamartoma. In this retrospective study, we aimed to examine the histopathological features of pulmonary hamartomas in lung, to evaluate the different histological components, especially PT, and to investigate importance of PT pattern and its relationship with other clinicopathological features.
METHODS: Thirty-five cases of pulmonary hamartomas were recruited from the records between 2001 and 2021, divided into two groups according to presence of PT, as PT (-) and PT (+) in pathological examination.
RESULTS: 77.1% of all patients were male. There was no significant difference between the two groups in terms of age, sex, comorbidity, presence of symptoms, tumor localization, and radiological findings (P > 0.05). Pulmonary hamartomas were resected totally from 28 patients (80%). Five of these patients (17.9%) had PT components in resection materials with varying degree between 5 and 80%, and all were from male patients. Examination with frozen sections were performed in 15 PT (-) and 5 PT (+) patients but diagnosis with frozen sections was not achieved in any of PT (+) patients. Most of materials included chondroid components (52.22 ± 29.7%) in both groups (P < 0.05).
CONCLUSIONS: The placental papillary projections are available patterns associated with a pulmonary hamartoma and these projections observed especially in frozen sections are very crucial to recognize PT pattern in hamartomas, as they can result in confusions in differential diagnosis of malignities.