■甲状旁腺癌非常罕见,术中明确的诊断可能是目前可用的诊断难以捉摸。近红外(NIR)自发荧光是一种新兴的工具,可以实时识别甲状旁腺。目前尚不清楚NIR自体荧光是否可以在术中检测甲状旁腺癌。
■术前怀疑甲状旁腺癌的患者通过使用近红外照相机和探针检测甲状旁腺自发荧光的持续研究来确定。术中检查这些患者的标本以确定其自发荧光模式。
■术前发现3例疑似甲状旁腺癌患者。术中近红外自发荧光成像显示所有病例的自发荧光相对缺乏,与甲状旁腺腺瘤和正常甲状旁腺相反,通常表现出显著的自发荧光。所有病例最终病理均为甲状旁腺癌。
■甲状旁腺癌可能难以在最终病理检查前确认。我们的3例病例表明,缺乏NIR自发荧光可能提示甲状旁腺癌的可能性,但是需要更多的研究来调查这种经历。
UNASSIGNED: Parathyroid carcinoma is very rare, and intraoperative definitive diagnosis can be elusive with currently available diagnostics. Near-infrared (NIR) autofluorescence is an emerging tool that identifies parathyroid glands in real time. It is not known whether NIR autofluorescence can detect parathyroid carcinoma intraoperatively.
UNASSIGNED: Patients with preoperative suspicion for parathyroid carcinoma were identified from ongoing studies examining parathyroid autofluorescence with a NIR camera and probe. Specimens from these patients were examined intraoperatively to determine their autofluorescence patterns.
UNASSIGNED: Three patients with suspected parathyroid carcinoma were identified preoperatively. Intraoperative NIR autofluorescence imaging showed a relative lack of autofluorescence for all cases, in contrast to parathyroid adenomas and normal parathyroid glands, which typically exhibit significant autofluorescence. Final pathology confirmed parathyroid carcinoma in all cases.
UNASSIGNED: Parathyroid carcinoma can be difficult to confirm prior to final pathology review. Our 3 cases suggest that absence of NIR autofluorescence may suggest the likelihood of parathyroid carcinoma, but more studies are needed to investigate this experience.