目标:2019年冠状病毒病(COVID-19)大流行期间社交距离的一个后果是饮酒障碍的增加。我们推测这与酒精相关的胃肠道和肝脏疾病的增加有关。
方法:使用探索公司,从1999年到2021年6月美国医疗保健系统的电子健康记录汇总,我们确定了酒精性肝炎患者,酒精引起的胰腺炎症,“和”酒精性胃炎,“基于医学临床术语的系统化命名法(SNOMED-CT)。我们将大流行期间利用医疗保健的患者与之前的患者进行了比较。
结果:我们确定了2020年6月21日至2021年6月20日接受治疗的8,445,720例患者(“COVID队列”)和在此之前接受治疗的65,587,860例患者(“COVID前队列”)。在COVID-19期间,非裔美国患者更有可能因各种原因接受治疗[比值比(OR):1.65;P<0.0001]。酒精性肝炎(OR:2.77),酒精性胰腺炎(OR:3.67),和酒精性胃炎(OR:1.70)(每个,P<0.0001)在COVID队列中的所有患者中更有可能。COVID队列中的非洲裔美国人更有可能被诊断为酒精性肝炎(OR:2.63),酒精性胰腺炎(OR:2.17),和酒精性胃炎(OR:3.09)[每个,P<0.0001]。
结论:在COVID-19期间,酒精相关性肝脏和胃肠道疾病的患病率增加。我们怀疑这些增加与由于社会孤立的压力而导致的酒精使用障碍增加有关。这些数据表明,COVID-19不成比例地影响了非洲裔美国人的整体医疗保健利用率,并增加了酒精性胃肠道和肝病的负担。
One consequence of social distancing during the coronavirus disease 2019 (COVID-19) pandemic was an increase in alcohol use disorders. We postulated that this would be associated with a rise in alcohol-related gastrointestinal and liver disease.
Using Explorys Inc., an aggregate of electronic health records from US health care systems from 1999 to June 2021, we identified patients with \"alcoholic hepatitis,\" \"inflammation of pancreas caused by alcohol,\" and \"alcoholic gastritis,\" based on Systematized Nomenclature of Medicine-Clinical Terms (SNOMED-CT). We compared patients utilizing health care during the pandemic to those before it.
We identified 8,445,720 patients treated from June 21, 2020 to June 20, 2021 (\"COVID cohort\") and 65,587,860 patients treated before this (\"pre-COVID cohort\"). African American patients were more likely to be treated for all causes during COVID-19 [odds ratio (OR): 1.65; P <0.0001]. Alcoholic hepatitis (OR: 2.77), alcoholic pancreatitis (OR: 3.67), and alcoholic gastritis (OR: 1.70) (for each, P <0.0001) were more likely in all patients in the COVID cohort. African Americans in the COVID cohort were more likely to be diagnosed with alcoholic hepatitis (OR: 2.63), alcoholic pancreatitis (OR: 2.17), and alcoholic gastritis (OR: 3.09) [for each, P <0.0001].
The prevalence of alcohol-related liver and gastrointestinal disease increased during COVID-19. We suspect these increases are associated with increased alcohol use disorder resulting from the stress of social isolation. These data suggest COVID-19 disproportionately affected African Americans in overall health care utilization and increased burden of alcoholic gastrointestinal and liver disease.