未经证实:尽管胰腺癌(PC)的预后极差,无浸润性癌(PHP)的胰腺高级别癌前病变患者的5年生存率良好。需要PHP诊断和识别需要干预的患者。我们旨在验证修改后的PC检测评分系统在普通人群中对PHP和PC的检测能力。
UNASSIGNED:我们修改了现有的PC检测评分系统,该系统结合了低等级风险(LGR)因素(家族史,存在糖尿病[DM]或恶化的DM,大量饮酒,吸烟,胃部症状,减肥,和胰酶)和高级别风险(HGR)因素(新发DM,家族PC,黄疸,肿瘤生物标志物,慢性胰腺炎,导管内乳头状黏液性肿瘤,囊肿,遗传性PC综合征,和遗传性胰腺炎)。每个因素评分为1分;LGR评分≥3分和/或HGR评分≥1分(阳性评分)指示PC。新修改的评分系统将主胰管扩张作为HGR因子。前瞻性分析了使用该评分系统结合EUS的PHP诊断率。
未经评估:在544名评分为阳性的患者中,10有PHPPHP的诊断率为1.8%,侵入性PC的诊断率为4.2%。尽管LGR和HGR因子的数量随着PC进展而增加,PHP患者和无病变患者的个体因素均无显著差异。
UNASSIGNED:评估与PC相关的多个因素的新修改的评分系统可能会识别出PHP或PC风险较高的患者。
UNASSIGNED: Although pancreatic cancer (PC) has an extremely poor prognosis, the 5-year survival rate of patients with pancreatic high-grade precancerous lesion without invasive carcinoma (PHP) is favorable. PHP diagnosis and identification of patients requiring intervention are needed. We aimed to validate a modified PC detection scoring system regarding its detection ability for PHP and PC in the general population.
UNASSIGNED: We modified an existing PC detection scoring system that incorporates low-grade risk (LGR) factors (family history, presence of diabetes mellitus [DM] or worsening DM, heavy drinking, smoking, stomach symptoms, weight loss, and pancreatic enzyme) and high-grade risk (HGR) factors (new-onset DM, familial PC, jaundice, tumor biomarkers, chronic pancreatitis, intraductal papillary mucinous neoplasm, cysts, hereditary PC syndrome, and hereditary pancreatitis). Each factor was scored as one point; LGR score ≥3 points and/or HGR score ≥1 point (positive scores) were indicative of PC. The newly modified scoring system incorporated main pancreatic duct dilation as an HGR factor. The PHP diagnosis rate using this scoring system combined with EUS was prospectively analyzed.
UNASSIGNED: Among 544 patients with positive scores, 10 had PHP. The diagnosis rates were 1.8% for PHP and 4.2% for invasive PC. Although the number of LGR and HGR factors tended to increase with PC progression, none of the individual factors were significantly different between patients with PHP and those without lesions.
UNASSIGNED: The newly modified scoring system evaluating multiple factors associated with PC could potentially identify patients with higher risk of PHP or PC.