■分析多模态磁共振成像(MRI)图像中定量特征的诊断价值,以构建乳腺癌的放射组学模型。
■将2020年1月至2021年1月95例乳腺相关疾病患者根据病理结果分为良性组(57例)和恶性组(38例)。根据检查时间以7:3的比例将所有病例随机分为训练组(n=66)和验证组(n=29)。所有受试者均进行T1加权成像(T1WI)检查,T2加权成像(T2WI),弥散加权成像(DWI),动态对比度增强(DCE),和表观扩散系数(ADC)多模态MRI。将MRI表现与病理结果进行对比分析。建立了诊断乳腺癌影像组学模型。分析验证组模型的诊断效能,通过ROC曲线分析诊断效能。
■纤维腺瘤占乳腺良性疾病的49.12%,浸润性导管癌占乳腺恶性疾病的73.68%。T1WI的灵敏度,T2WI,DWI,ADC,诊断乳腺癌的DCE为61.14%,66.67%,73.30%,78.95%,85.96%,使用四折表法。T1WI的曲线下面积(AUCs),T2WI,DWI,ADC,诊断乳腺癌的DCE分别为0.715、0.769、0.785、0.835和0.792。普通扫描的AUC,弥漫,增强,平扫+弥漫性扫描,普通扫描+增强,增强+弥漫性,平扫+增强+弥漫性诊断乳腺癌分别为0.746、0.798、0.816、0.839、0.890、0.906和0.927。
■通过多模态MRI图像中的定量特征构建放射组学模型对乳腺癌的诊断具有重要价值。平扫+增强+弥漫性等放射组学模型在乳腺癌诊断中的价值高于其他模型,可广泛应用于临床。
UNASSIGNED: To analyze the diagnostic value of quantitative features in multimodal magnetic resonance imaging (MRI) images to construct a radio-omics
model for breast cancer.
UNASSIGNED: Ninety-five patients with breast-related diseases from January 2020 to January 2021 were grouped into the benign group (n=57) and malignant group (n=38) according to the pathological findings. All cases were randomized as the training group (n=66) and validation group (n=29) in a 7:3 ratio based on the examination time. All subjects were examined by T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), dynamic contrast enhancement (DCE), and apparent diffusion coefficient (ADC) multimodality MRI. The MRI findings were analyzed against pathological findings. A diagnostic breast cancer radiomics
model was constructed. The diagnostic efficacy of the
model in the validation group was analyzed, and the diagnostic efficacy was analyzed via the ROC curve.
UNASSIGNED: Fibroadenoma accounted for 49.12% of benign breast diseases, and invasive ductal carcinoma accounted for 73.68% of malignant breast diseases. The sensitivity of T1WI, T2WI, DWI, ADC, and DCE in diagnosing breast cancer was 61.14%, 66.67%, 73.30%, 78.95%, and 85.96%, using the four-fold table method. The area under the curves (AUCs) of T1WI, T2WI, DWI, ADC, and DCE for diagnosing breast cancer were 0.715, 0.769, 0.785, 0.835, and 0.792, respectively. The AUCs of plain scan, diffuse, enhanced, plain scan + diffuse, plain scan + enhanced, enhanced + diffuse, and plain scan + enhanced + diffuse for diagnosing breast cancer were 0.746, 0.798, 0.816, 0.839, 0.890, 0.906, and 0.927, respectively.
UNASSIGNED: The construction of a radio-omics
model by quantitative features in multimodal MRI images was valuable in the diagnosis of breast cancer. The value of radio-omics models such as plain scan + enhanced + diffuse was higher than the other models in diagnosing breast cancer and could be widely applied in clinical practice.