背景:Melkersson-Rosenthal综合征(MRS)是一种罕见的神经粘膜皮肤疾病,以复发性水肿为特征,面部麻痹,和通常与plicata舌相关的神经功能障碍。虽然MRS的病因尚不清楚,越来越多的证据表明自身免疫参与。
方法:本文报道一例25岁男性,以MRS为首发症状,其次是颞下颌关节骨关节炎(TMJ-OA)。包括手术在内的综合诊断和多学科治疗方法,局部注射,并实施了口服药物治疗,导致良好的预后。
结论:这些发现支持MRS是由自身免疫引起的全身性肉芽肿病的假设,也可能通过免疫相关机制影响TMJ-OA的发生和发展。这项研究强调了全身免疫调节在MRS和TMJ-OA合并症患者治疗中的意义。
BACKGROUND: Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disorder characterized by recurrent edema, facial palsies, and nerve dysfunctions often associated with the plicata tongue. Although the etiology of MRS is not well understood, there is growing evidence suggesting an autoimmune involvement.
METHODS: This paper presents a case report of a 25-year-old male with MRS as the initial symptom, followed by temporomandibular joint osteoarthritis (TMJ-OA). A comprehensive diagnosis and multidisciplinary treatment approach including surgery, local injections, and oral medication were implemented, resulting in a favorable prognosis.
CONCLUSIONS: These findings support the hypothesis that MRS is a systemic granulomatous disease caused by autoimmunity, which may also influence the occurrence and development of TMJ-OA through immune-related mechanisms. This study emphasizes the significance of systemic immune regulation in the treatment of patients with MRS and TMJ-OA comorbid conditions.