关于形态右心室解剖结构的几个方面的争议仍在继续。对于是否应该以双向或三方方式评估心室存在分歧,以及在三尖瓣中发现的小叶数量。特别是,对于正常构造的心脏中是否存在肌肉出口隔膜,尚无共识,也不知道在正常发育过程中会发现多少间隔成分。解决这些问题对于调查和治疗先天性心脏畸形儿童具有潜在的意义。考虑到所有这些问题,我们在研究正常右心室的发育和形态方面重新审视了自己的经验。为了评估发展,我们检查了大量的数据集,通过标准和episcopic显微镜制备,来自人类和小鼠的胚胎。在大体解剖学方面,我们比较了正常解剖心脏的解剖与使用计算机断层扫描准备的数据集的虚拟解剖.我们的发育和产后研究,放在一起,确认以三方方式最好地评估心室,三个部分代表它的入口,顶端小梁,和出口组件。室间隔,然而,只有肌肉和膜质成分。肌肉部分包含来自肌肉融合的近端流出垫的一小部分,但是这一部分无法与独立的肌肉漏斗套中包含的更大的部分区分开。我们确认三尖瓣本身有三个组成部分,它们位于低处,septally,和前上级。
Controversies continue regarding several aspects of the anatomy of the morphologically right ventricle. There is disagreement as to whether the ventricle should be assessed in bipartite or tripartite fashion, and the number of leaflets to be found in the tricuspid valve. In particular, there is no agreement as to whether a muscular outlet septum is present in the normally constructed heart, nor how many septal components are to be found during normal development. Resolving these issues is of potential significance to those investigating and treating children with congenitally malformed hearts. With all these issues in mind, we have revisited our own experience in investigating the development and morphology of the normal right ventricle. To assess development, we have examined a large number of datasets, prepared by both standard and episcopic microscopy, from human and murine embryos. In terms of gross anatomy, we have compared dissections of normal autopsied hearts with virtual dissections of datasets prepared using computed tomography. Our developmental and postnatal studies, taken together, confirm that the ventricle is best assessed in tripartite fashion, with the three parts representing its inlet, apical trabecular, and outlet components. The ventricular septum, however, has only muscular and membranous components. The muscular part incorporates a small component derived from the muscularised fused proximal outflow cushions, but this part cannot be distinguished from the much larger part that is incorporated within the free-standing muscular infundibular sleeve. We confirm that the tricuspid valve itself has three components, which are located inferiorly, septally, and antero-superiorly.