Incidental finding

偶然发现
  • 文章类型: Case Reports
    颅内脑膜瘤是最常见的原发性脑肿瘤,通常具有明确的成像特征。该病例报告主要针对一名56岁的女性患者,该患者因头部外伤史和偶然的占位性发现而被转诊,以调查颅内脑膜瘤的非典型影像学表现,专注于具有不同放射学结果的特定病例。脑膜瘤通常与特定的放射学特征有关,例如对比度增强,硬脑膜尾部,和骨增生。然而,这一特殊病例表现出非典型的影像学特征,引起了对潜在肿瘤类型的担忧.深入分析和随后的组织病理学检查显示,世界卫生组织(WHO)II级非典型脑膜瘤。这种脑膜瘤的变异表现出细胞增加,核非典型性,和高的有丝分裂指数,表明更具侵袭性的肿瘤行为。该研究强调了识别脑膜瘤中非典型影像学表现的重要性,因为它们可能表明具有潜在不同临床病程和治疗方法的高级别肿瘤。准确识别这些非典型特征有助于提高诊断准确性,并指导颅内脑膜瘤患者的适当手术决策。
    Intracranial meningiomas are the most common primary brain tumors, typically presenting with well-defined imaging characteristics. This case report focuses on a 56-year-old female patient who was referred due to a history of head trauma and an incidental space-occupying finding to investigate the atypical imaging appearances of intracranial meningiomas, focusing on a specific case with distinct radiological findings. Meningiomas are commonly associated with specific radiological features, such as contrast enhancement, dural tail, and hyperostosis. However, this particular case exhibited atypical imaging characteristics that raised concerns about the underlying tumor type. In-depth analysis and subsequent histopathological examination revealed a World Health Organization (WHO) grade II atypical meningioma. This variant of meningioma demonstrated increased cellularity, nuclear atypia, and a high mitotic index, indicating more aggressive tumor behavior. The study highlights the importance of recognizing atypical imaging appearances in meningiomas, as they may indicate higher-grade tumors with a potentially different clinical course and management approach. Accurate identification of these atypical features can contribute to improved diagnostic accuracy and guide appropriate surgical decision-making for patients with intracranial meningiomas.
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  • 文章类型: Journal Article
    肩部的CT和MRI扫描可以导致偶然发现(IF)的识别,这可能对患者的进一步治疗产生重大影响。这项回顾性研究的目的是记录IF的患病率,CT和MRI检查肩关节的偶发瘤(IT)和恶性IT,并探讨患者特征对IF的统计发生率的影响,IT和恶性IT。
    总共903次肩部检查(415次CT,488MRI)回顾性分析是否存在IF,随后分类(无害IF,需要澄清的IT,恶性IT)并分析患者特征。使用独立的t检验和卡方检验进行统计分析。设定P<0.05的显著性水平。
    在接受评估的903名患者中(436名女性,467男性),153例(16.9%)患者经历了IF(无害IF:101例(11.2%)患者,IT:94(10.4%),恶性IT:4(0.4%)。无IF和IT患者的平均年龄显著低于有IF和IT患者(p<0.001)。如果发生在31.1%的CT中,仅在4.9%的MRI中检测到IF(p<0.001)。
    如果患病率很高(16.9%),尤其是肩部的CT检查,随着年龄的增长。准确检测和开始适当的治疗是非常重要的临床,因为早期发现危及生命的疾病可以实现更有效的治疗,并有可能获得健康和寿命。
    UNASSIGNED: CT and MRI scans of the shoulder can lead to the identification of incidental findings (IF), which can have a major impact on the further treatment of the patient. The aim of this retrospective study was to record the prevalence of IF, incidentalomas (IT) and malignant IT for CT and MRI examinations of the shoulder and to investigate the effect of patient characteristics on the statistical occurrence of IF, IT and malignant IT.
    UNASSIGNED: A total of 903 shoulder examinations (415 CT, 488 MRI) were retrospectively analyzed for the presence of IF, subsequently categorized (harmless IF, IT requiring clarification, malignant IT) and analyzed regarding patient characteristics. The statistical analysis was carried out using independent t- and chi-square tests. A significance level of p < 0.05 was set.
    UNASSIGNED: Among the 903 patients evaluated (436 female, 467 male), 153 (16.9%) patients experienced IF (harmless IF: 101 (11.2%) patients, IT: 94 (10.4%), malignant IT: 4 (0.4%). The average age of the patients without IF and IT was significantly lower compared to the patients with IF and IT (p < 0.001). While IF occurred in 31.1% of the CT, IF was only detected in 4.9% of the MRI (p < 0.001).
    UNASSIGNED: IF have a high prevalence (16.9%), especially in CT examinations of the shoulder, which increases with age. The exact detection and initiation of appropriate therapy is of great clinical importance, as early detection of life-threatening diseases enables more effective treatment and a potential gain in health and lifespan.
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  • 文章类型: Journal Article
    背景:心包积液(PE)的偶然发现对临床护理提出了挑战。PE与恶性病症或严重心脏疾病相关,但也可在健康个体中观察到。这项研究探讨了患病率,决定因素,当然,以及基于人群的队列中PE的预后相关性。
    结果:STAAB(心力衰竭A/B阶段的特征和过程以及进展的决定因素)队列研究招募了维尔茨堡人口的代表性样本,30至79岁。参与者接受了质量控制的经胸超声心动图检查,包括对心包空间的专门评估。在基线纳入的4965名个体中(平均年龄,55±12岁;52%的女性),134(2.7%)表现出偶然诊断的PE(中位直径,2.7毫米;四分位数,2.0-4.1毫米)。在多变量逻辑回归中,较低的体重指数和较高的NT-proBNP(N末端B型利钠肽前体)水平与基线时的PE相关,而炎症,恶性肿瘤,和类风湿疾病没有。在中位时间为34(30-41)个月后参加随访检查的3901名参与者中,在60个人中发现了PE(1.5%;n=18个新PE,n=42持久性PE)。在后续期内,37名参与者死亡,93名参与者报告了新诊断的恶性肿瘤。PE的存在并不能预测全因死亡或新恶性肿瘤的发展。
    结论:在约3%的个体中检测到偶然的PE,与绝大多数测量<10毫米和完全解决。PE与炎症标志物无关,死亡,突发心力衰竭,或者恶性肿瘤。我们的发现证实了当前指南的观点,即无症状个体中的小PE可以被认为是无辜的现象,不需要广泛的短期监测。
    BACKGROUND: The incidental finding of a pericardial effusion (PE) poses a challenge in clinical care. PE is associated with malignant conditions or severe cardiac disease but may also be observed in healthy individuals. This study explored the prevalence, determinants, course, and prognostic relevance of PE in a population-based cohort.
    RESULTS: The STAAB (Characteristics and Course of Heart Failure Stages A/B and Determinants of Progression) cohort study recruited a representative sample of the population of Würzburg, aged 30 to 79 years. Participants underwent quality-controlled transthoracic echocardiography including the dedicated evaluation of the pericardial space. Of 4965 individuals included at baseline (mean age, 55±12 years; 52% women), 134 (2.7%) exhibited an incidentally diagnosed PE (median diameter, 2.7 mm; quartiles, 2.0-4.1 mm). In multivariable logistic regression, lower body mass index and higher NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels were associated with PE at baseline, whereas inflammation, malignancy, and rheumatoid disease were not. Among the 3901 participants attending the follow-up examination after a median time of 34 (30-41) months, PE was found in 60 individuals (1.5%; n=18 new PE, n=42 persistent PE). Within the follow-up period, 37 participants died and 93 participants reported a newly diagnosed malignancy. The presence of PE did not predict all-cause death or the development of new malignancy.
    CONCLUSIONS: Incidental PE was detected in about 3% of individuals, with the vast majority measuring <10 mm and completely resolving. PE was not associated with inflammation markers, death, incident heart failure, or malignancy. Our findings corroborate the view of current guidelines that a small PE in asymptomatic individuals can be considered an innocent phenomenon and does not require extensive short-term monitoring.
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  • 文章类型: Case Reports
    肩胛骨翅膀的主要原因,也被称为肩胛骨,通常是前锯肌的故障,斜方肌,和菱形,三个主要的肩胛骨稳定器。肩胛骨翼通常是由胸长神经损伤引起的,削弱了前锯齿肌。由于长胸神经的病程较长,因此特别容易受到急性和非创伤性损伤。很少有记录的孤立的肩胛骨翼。这里,我们介绍了一名15岁的亚裔女性,她最初表现为右侧软骨疼痛,在一般体检中,注意到一个偶然发现的左翼肩胛骨。
    The primary cause of scapular winging, also known as scapula alata, is typically a malfunction of the serratus anterior, trapezius, and rhomboids, the three major scapular stabilizers. Scapular winging is often caused by injuries to the long thoracic nerve, which weakens the serratus anterior muscle. The long thoracic nerve is particularly vulnerable to both acute and nontraumatic damage due to its longer and superficial course. There are very few documented cases of isolated scapula winging. Here, we present the case of a 15-year-old Asian female who initially presented with right hypochondrium pain, and during a general physical examination, an incidental finding of a left-winged scapula was noted.
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  • 文章类型: Case Reports
    阻塞性黄疸,由于胆汁流量减少,皮肤和粘膜呈黄色变色,通常需要手术干预才能解决。本文提供了一个全面的文献综述,以了解梗阻性黄疸的治疗背景,重点介绍胰头癌的常见治疗方式,如胆总管(CBD)支架置入术和Whipple手术。此外,详细描述了胰头癌手术干预期间胆囊的Phrygian帽的偶然发现。概述了一名48岁女性患有阻塞性黄疸和胰头癌的病例介绍,详细说明诊断过程,治疗决定,和手术干预。患者接受了CBD支架置入术,随后接受了Whipple手术以治疗胰头癌,在此期间,偶然发现了胆囊的Phrygian帽。对偶然发现的讨论强调了它增加了手术干预的复杂性,并强调了适应性和精确性在管理解剖变化中的重要性。与类似案例的比较强调了管理偶然发现的不同方法,从保守观察到基于临床适应症的手术切除。此病例强调了彻底的诊断评估和手术干预在管理诸如Phrygian帽之类的偶然发现中的重要性,在复杂的手术情况下确保适当的患者管理和良好的临床结果。
    Obstructive jaundice, characterised by yellow discolouration of the skin and mucous membranes due to reduced bile flow, often necessitates surgical intervention for resolution. This article provides a comprehensive literature review to contextualise the management of obstructive jaundice, focusing on common treatment modalities such as common bile duct (CBD) stenting and Whipple\'s procedure for pancreatic head cancer. Additionally, the incidental finding of a Phrygian cap of the gallbladder during surgical intervention for pancreatic head cancer is described in detail. A case presentation of a 48-year-old female with obstructive jaundice and pancreatic head cancer is outlined, detailing the diagnostic process, treatment decisions, and surgical interventions. The patient underwent CBD stenting followed by Whipple\'s procedure to address the pancreatic head cancer, during which the incidental discovery of a Phrygian cap of the gallbladder was noted. The discussion of the incidental finding highlights the complexity it adds to surgical interventions and emphasises the importance of adaptability and precision in managing anatomical variations. A comparison with similar cases underscores varying approaches to managing incidental findings, ranging from conservative observation to surgical excision based on clinical indications. This case underscores the significance of thorough diagnostic evaluation and surgical intervention in managing incidental findings such as the Phrygian cap, ensuring appropriate patient management and favourable clinical outcomes in complex surgical scenarios.
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  • 文章类型: Journal Article
    现在公认的非侵入性产前检测(NIPT),最初设计用于筛查母体血液中的无细胞DNA(cfDNA)是否存在常见的胎儿三体,可能导致偶然发现隐匿性母体恶性肿瘤。回顾性评估已经证明,cfDNA中的多拷贝数改变的检测特别提示初期肿瘤,并且癌症检测率不仅取决于肿瘤生物学,而且取决于应用的NIPT技术和下游诊断研究。由于在怀孕期间确定母体癌症对妇女和未出生的孩子都有影响,需要前瞻性研究来提供最佳临床实践和患者预后方面的临床效用的证据.
    It is now well-established that non-invasive prenatal testing (NIPT), originally designed to screen cell-free DNA (cfDNA) in maternal blood for the presence of common fetal trisomies, can lead to incidental detection of occult maternal malignancies. Retrospective evaluations have demonstrated that the detection of multiple copy number alterations in cfDNA is particularly suggestive of an incipient tumor and that cancer detection rates not only depend on tumor biology but also on applied NIPT technologies and downstream diagnostic investigations. Since the identification of a maternal cancer in pregnancy has implications for both woman and the unborn child, prospective studies are needed to provide evidence on best clinical practices and on clinical utility in terms of patient outcomes.
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  • 文章类型: Case Reports
    未分化肉瘤被认为是一种罕见且侵袭性的软组织肉瘤,据报道下肢是软组织肉瘤的常见部位。
    我们在一名49岁女性中,在下肢多普勒超声检查中发现了罕见的未分化肉瘤,并表现为右侧血栓性小腿疼痛。
    关于超声波,呈现的未分化肉瘤表现为一个大的异质性,椭圆形,软组织肿块深深坐于右小腿,受累于比目鱼肌。超声的特征模仿了血肿的特征;然而,通过彩色多普勒应用显示内部血管,迅速排除了病变为血肿的可能性。然后将该病例转交给肉瘤分诊多学科小组进行审查。磁共振成像,计算机断层扫描和活检是这种情况的诊断检查的一部分,组织学证实软组织病变为未分化肉瘤。急诊右腿膝盖以上截肢术作为患者治疗的一部分。
    本病例报告提供了一种罕见的偶然发现,在下肢多普勒超声检查中发现未分化肉瘤,引起血栓性小腿疼痛。鼓励超声检查者在下肢多普勒超声压缩期间进行必要的注意并仔细检查任何相邻和偶然的软组织病变,二维成像和彩色成像,尤其是那些表现为恶性肿瘤的特征性病例;应将此类病例紧急转诊至三级软组织肉瘤中心进行进一步评估和治疗。
    UNASSIGNED: Undifferentiated sarcoma is considered a rare and aggressive type of soft tissue sarcoma with the lower extremity reported as the common site for soft tissue sarcomas.
    UNASSIGNED: We present a rare incidental finding of undifferentiated sarcoma during lower limb Doppler ultrasound with a presenting symptom of right thrombotic-like calf pain in a 49-year-old female.
    UNASSIGNED: On ultrasound, the presented undifferentiated sarcoma appeared as a large heterogeneous, oval-shaped, soft tissue mass deeply seated in the right calf with involvement of the soleus muscle. The features on ultrasound mimicked those of a hematoma; however, the possibility of the lesion being a haematoma was promptly ruled out with the demonstration of internal vascularity on colour Doppler application. The case was then referred to a sarcoma triage multidisciplinary team for a review. Magnetic resonance imaging, computed tomography and biopsy were parts of the diagnostic workup for this case, histology confirmed the soft tissue lesion to be an undifferentiated sarcoma. Emergency above knee amputation of the right leg was performed as part of the patient\'s treatment.
    UNASSIGNED: This case report presents a rare incidental finding of undifferentiated sarcoma encountered during lower limb Doppler ultrasound causing thrombotic-like calf pain. Sonographers are encouraged to pay necessary attention and carefully examine any adjacent and incidental soft tissue lesion during lower limb Doppler ultrasound using compression, two-dimensional imaging and colour imaging, especially those that appear with characteristic features of malignancy; urgent referral should be made of such cases to a tertiary soft tissue sarcoma centre for further evaluation and management.
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  • 文章类型: Case Reports
    我们概述了一名68岁妇女的介绍,由于她的保险要求,她接受了胸部X光片,导致左侧胸腔积液的发现。积液进一步表征为位于随后的成像中。胸腔穿刺术产生了渗出液,导致患者接受电视胸腔镜手术(VATS)。在此过程中,可见囊性肿块,随着手术转变为开胸手术和左下叶肺叶切除术。病理为梭形细胞肉瘤。患者的详尽病史显示,数十年的职业暴露于石棉。这份报告的意义是说明临床表现,免疫组织化学特征,以及罕见梭形细胞恶性肿瘤的治疗。我们的案例也提高了对患者进行个性化筛查的重要性,共同的决策依据。
    We outline the presentation of a 68-year-old woman who received a chest radiograph due to her insurance requirements, resulting in the discovery of a left-sided pleural effusion. The effusion was further characterized as loculated on subsequent imaging. Thoracentesis yielded exudative fluid, leading to the patient undergoing video-assisted thoracoscopic surgery (VATS). During this procedure, a cystic mass was visualized, with the conversion of the operation to an open thoracotomy and left lower lobe lobectomy. Pathology was positive for spindle cell sarcoma. A thorough history of the patient revealed a decades-long occupational exposure to asbestos. The significance of this report is to illustrate the clinical presentation, immunohistochemical characteristics, and management of a rare spindle cell malignancy. Our case also raises the importance of screening patients on an individualized, shared decision-making basis.
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  • 文章类型: Case Reports
    Riedel的肝叶是一种罕见的解剖变异,通常在影像学检查中偶然发现或通过体格检查中存在肝肿大。虽然患者通常无症状,这种情况的表现可能会有所不同,从非特异性症状到更严重的问题,如扭转,阻塞,破裂,和出血。我们介绍了一个无症状的肝肿大患者,偶然发现他有肝脏的里德尔叶,伴有升高的IgG线粒体抗体。与这种罕见的解剖变异相关的症状范围强调了其在该患者人群中的诊断和监测中的重要性。
    Riedel\'s lobe of the liver is a rare anatomical variant often incidentally found on imaging or through the presence of hepatomegaly on physical examination. While patients are usually asymptomatic, the presentation of this condition can vary, ranging from nonspecific symptoms to more severe issues such as torsion, obstruction, rupture, and bleeding. We present a case of a patient with asymptomatic hepatomegaly who was incidentally found to have Riedel\'s lobe of the liver, accompanied by an elevated IgG mitochondrial antibody. The range of symptoms associated with this rare anatomical variation underscores its importance in diagnosis and surveillance within this patient population.
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  • 文章类型: Journal Article
    对普通人群进行癌症筛查是降低疾病负担的一级预防问题。虽然这对包括乳腺癌在内的几种癌症都是成功的,结肠和前列腺,筛查和预防胰腺癌的情况是不同的。该器官不容易获得简单的身体检查或生物样本(粪便或血液测试)。两者都不存在具有成本效益的血液测试,例如PSA。回顾胰腺癌风险组筛查的证据,必须得出结论,目前没有理性来筛查普通人群,缺乏适当的测试。
    Screening of the general population for cancer is a matter of primary prevention reducing the burden of disease. Whilst this is successful for several cancers including breast, colon and prostate, the situation to screen and hence prevent pancreatic cancer is different. The organ is not as accessible to simple physical exam or biological samples (fecal or blood test). Neither exists a blood test such as PSA that is cost-effective. Reviewing the evidence from screening risk groups for pancreatic cancer, one must conclude that there is no rational at present to screen the general population, for a lack of appropriate tests.
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