未经证实:评估癫痫发作后肌酸激酶(高CK血症)升高的独立危险因素。
UNASSIGNED:本回顾性研究中包含的数据来自2017年7月1日至2022年3月31日的两家医院。从急诊科或患者入院后24小时内获取临床和实验室数据。选择具有统计学差异(P<0.05)的变量用于进一步分析。体温之间的关联(BT),白细胞计数(LEU),中性粒细胞百分比(NEU),C反应蛋白(CRP)和肌酸激酶(CK)水平采用二元logistic回归分析。
未经评估:研究中纳入了123例癫痫患者,根据CK水平>CK正常范围上限的1.5倍,39例(31.7%)患者出现了高CK血症。患者特征之间没有观察到统计学差异,癫痫发作相关参数,或电解质水平。然而,BT,LEU,NEU,与CK水平正常的患者相比,高CK血症患者的CRP升高。具体来说,BT≥37.5°C(发热)和LEU>9.5×109/L(LEU升高)与高CK血症呈正相关,并显示调整后的OR为8.87(95%CI:2.11-37.24,P=0.003)和3.01(95%CI:1.12-8.05,P=0.029),分别。
未经批准:在这项研究中,31.7%的患者在癫痫发作后发生高CK血症.发热和LEU升高是癫痫相关高CK血症的独立危险因素。早期认识到癫痫相关的高CK血症的风险将有利于采取预防措施。
UNASSIGNED: To evaluate the independent risk factors for elevated creatine kinase (
hyperCKemia) after seizures.
UNASSIGNED: Data included in this retrospective study were obtained from two hospitals from July 1, 2017, to March 31, 2022. Clinical and laboratory data were acquired from the emergency department or within 24 h after patient admission. Variables that exhibited statistical differences (P < 0.05) were selected for further analysis. Associations between body temperature (BT), leukocyte count (LEU), percentage of neutrophils (NEU), and C-reactive protein (CRP) and creatine kinase (CK) levels were assessed using binary logistic regression analysis.
UNASSIGNED: One hundred twenty-three patients who exhibited seizures were included in the study, and 39 (31.7%) patients exhibited hyperCKemia based on a CK level that was >1.5 times the upper limit of the normal range for CK. No statistical differences were observed among the patient characteristics, seizure-related parameters, or electrolyte levels. However, BT, LEU, NEU, and CRP were elevated in patients with
hyperCKemia compared to patients with normal CK levels. Specifically, a BT ≥ 37.5 °C (fever) and LEU >9.5×109/L (elevated LEU) exhibited positive correlations with hyperCKemia, and presented an adjusted OR of 8.87 (95% CI: 2.11-37.24, P = 0.003) and 3.01 (95% CI: 1.12-8.05, P = 0.029), respectively.
UNASSIGNED: In this study,
hyperCKemia occurred in 31.7% of patients after seizures. Fever and elevated LEU were independent risk factors for seizure-related
hyperCKemia. Earlier recognition of risks for seizure-related
hyperCKemia would be beneficial in taking prophylactic measures.