背景和目的:扑热息痛过量是一个重要的全球性问题,这可能导致对其潜在副作用缺乏认识。扑热息痛会伤害肝脏,可能导致肝功能衰竭.相反,这项研究采用了来自石油脆皮(PC)的提取物,以其丰富的生物活性化合物而闻名,具有先前研究中显示的抗氧化特性以及对各种疾病的保护作用。这项研究的主要目的是研究Petoselinumcrispum对暴露于扑热息痛的大鼠血液中血液学和生化参数改变的潜在保护作用。材料和方法:本研究涉及20只Wistar大鼠,分为4组。不同组的雄性大鼠每天服用200mg/kg体重的PC提取物,持续15天,以及200mg/kg的对乙酰氨基酚的标准参考剂量。该研究通过分析肝酶如天冬氨酸转氨酶(AST)评估肝脏保护能力,丙氨酸氨基转移酶(ALT),胆红素,白蛋白,和脂质分布。通过肌酐评估肾脏安全性,尿素,尿酸,乳酸脱氢酶(LDH),和总蛋白质。此外,进行了肝脏和肾脏的组织病理学检查。结果:扑热息痛过量后,血红蛋白水平下降,血清总蛋白,白蛋白,和尿酸。扑热息痛过量也升高了几种血液生物标志物的水平,包括肌酐,尿素,氮,ALT,AST,甘油三酯,LDH活性,白细胞计数,和血小板计数与对照组相比。然而,使用Petoselinumcrispum的乙醇提取物可显着减轻这些改变的严重程度以及与施用剂量相关的作用程度。欧芹提取物有助于预防蛋白尿和低血红蛋白,这是扑热息痛的常见副作用。结论:因此,欧芹可能在治疗肝脏和肾脏疾病方面有希望,特别是在解决蛋白尿方面。最终,这些结果可能通过减轻扑热息痛诱导的肾脏对人类健康有影响,肝,和血液学毒性。
Background and Objectives: Paracetamol overdose is a significant global issue due to its widespread use, which can lead to a lack of awareness regarding its potential side effects. Paracetamol can harm the liver, possibly resulting in liver failure. Conversely, this study employed extracts from Petroselinum crispum (PC), known for its rich content of bioactive compounds, with demonstrated antioxidant properties shown in previous research as well as protective effects against various diseases. The primary objective of this study was to investigate the potential protective effects of Petroselinum crispum on altered hematological and biochemical parameters in the blood of rats exposed to paracetamol. Materials and Methods: The study involved twenty Wistar rats divided into four groups. Different groups of male rats were administered PC extract at 200 mg/kg body weight daily for 15 days, along with a standard reference dose of paracetamol at 200 mg/kg. The study assessed hepatoprotection capacity by analyzing liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, albumin, and lipid profiles. Renal safety was evaluated through creatinine, urea, uric acid, lactate dehydrogenase (LDH), and total protein. Additionally, histopathological examinations of the liver and kidneys were conducted. Results: Following Paracetamol overdose, there were reductions in hemoglobin levels, serum total protein, albumin, and uric acid. Paracetamol overdose also elevated levels of several blood biomarkers, including creatinine, urea, nitrogen, ALT, AST, triglycerides, LDH activity, white blood cell count, and platelet count compared to the control group. However, using an ethanolic extract of Petroselinum crispum significantly mitigated the severity of these alterations and the extent of the effect correlated with the dose administered. Parsley extract helped prevent proteinuria and low hemoglobin, which are common side effects of Paracetamol. Conclusions: Therefore, parsley may hold promise in managing liver and kidney conditions-particularly in addressing proteinuria. Ultimately, these results may have implications for human health by potentially mitigating paracetamol-induced renal, hepatic, and hematological toxicity.