■这项研究的目的是评估人口统计学特征,危险因素,死亡率,新生儿重症监护病房(NICU)真菌败血症婴儿的实验室检查结果。
■这项回顾性多中心研究纳入了2019年11月1日至2022年9月1日之间血液培养中分离的念珠菌属NICU患者。对两组患者进行评估,分别为第1组白色念珠菌婴儿和第2组非白色念珠菌血培养阳性婴儿。
■在入住NICU的3450例患者中的57例血培养中检测到念珠菌感染。总共57名婴儿被纳入研究。在研究人群中,有1.6%的婴儿被确定为念珠菌感染,其中57%为早产儿。在实验室数据方面,两组之间没有显着差异。在第1组中,正常的阴道分娩率较高。在第2组中,住院时间,全胃肠外营养(TPN)的持续时间,和机械通气(MV)被确定为更长。由于念珠菌菌血症的死亡率被确定为35%,在这些病人中,65%有额外的医疗条件。
■根据文献,这项研究表明,延长的MV和更长的TPN会增加真菌败血症的发生率。因此,降低NICU真菌败血症的发生率,建议缩短住院时间并实施有效的筛查方案.
UNASSIGNED: The aims of this study were to evaluate the demographic characteristics, risk factors, mortality rates, and laboratory findings of infants with fungal sepsis in the Neonatal Intensive Care Unit (NICU).
UNASSIGNED: This retrospective multicenter study included patients in NICU with Candida spp isolated in blood cultures between November 01, 2019, and September 01, 2022. The patients were evaluated in two groups as Group 1 infants with Candida albicans and Group 2 infants with Candida non-albicans positive blood cultures.
UNASSIGNED: Candida infection was detected in blood cultures in 57 of 3450 patients admitted to the NICU. A total of 57 infants included in the study. Candida infection was determined 1.6% of infants in the study population, and 57% of them were extremely pre-term infants. There was no significant difference between the two groups in terms of laboratory data. Normal vaginal birth was determined at a higher rate in Group 1. In Group 2, length of hospital stay, duration of total parenteral nutrition (TPN), and mechanical ventilation (MV) were determined to be longer. The mortality due to Candida fungemia was determined as 35%, and of these patients, 65% had an additional medical condition.
UNASSIGNED: In accordance with the literature, this study showed that prolonged MV and longer TPN increased the incidence of fungal sepsis. Therefore, to decrease the fungal sepsis rate of NICU, shortening the hospital stay and effective screening programs are recommended.