Foot Diseases

足部疾病
  • 文章类型: English Abstract
    UNASSIGNED: The Swiss Claw Health Project (SCHP) started on 1 January 2019 and will last a total of 8 years. The main goals of the SCHP are (a) digital recording of claw health data of cattle in Switzerland by 100 professional claw trimmers, (b) development of claw health programs, (c) improvement of cattle claw health in Switzerland, (d) development of breeding values for claw health and (e) reduction of antibiotic use to control claw health problems.
    METHODS: Data was collected digitally by 45 hoof trimmers who had previously successfully completed the training program for diagnosis and digital documentation in accordance with the ICAR Claw Health Atlas. The national animal health database was further developed for data storage. Livestock farms with unfavorable claw health were offered an on farm analysis with subsequent annual support visits.
    RESULTS: A total of 1155 cattle owners joined the project by the end of the 5th project year. The claw health data of 149753 claw trimmings at cow-level was recorded, and 176 individual visits and analyses of farms with claw health issues were carried out. A health program for mechanical and metabolism-related claw disorders was developed and successfully established. Biosecurity measures during claw trimming were analyzed, and a brochure with recommendations for claw trimmers was developed. Risk factors for the occurrence of digital dermatitis in dairy herds were identified. The prevalence of alarm lesions (painful lesions) decreased significantly and continuously in the participating farms over the project years 2 to 4.
    CONCLUSIONS: The scientific project support proved to be extremely useful, as the progress of the project was continuously monitored, and new issues could be addressed promptly. Digitally recorded findings during herd hoof trimming are essential for monitoring and improving claw health.
    CONCLUSIONS: This description and critical assessment of the SKGP procedure can be used by other consortia planning a similar project.
    UNASSIGNED: Das Schweizer Klauengesundheitsprojekt (SKGP) begann am 1.1.2019 und dauert 8 Jahre. Die Hauptziele des SKGP sind (a) die digitale Erhebung von Klauengesundheitsdaten bei Rindern in der Schweiz im Rahmen der Klauenpflege durch 100 gewerbsmäßig arbeitende Klauenpfleger, (b) die Erarbeitung von Klauengesundheitskonzepten, (c) die Verbesserung der Klauengesundheit bei Rindern in der Schweiz, (d) die Erarbeitung von Zuchtwerten für Klauengesundheit und (e) die Reduktion des Einsatzes von Antibiotika zur Bekämpfung von Klauengesundheitsproblemen.
    METHODS: Die Datenerhebung erfolgte digital durch 45 Klauenpfleger, welche vorgängig das Fortbildungsprogramm zur Befundung und digitalen Dokumentation gemäß ICAR Atlas der Klauengesundheit erfolgreich abgeschlossen hatten. Für die Datenspeicherung wurde die nationale Tiergesundheitsdatenbank weiterentwickelt. Tierhaltungsbetrieben mit ungünstiger Klauengesundheit wurde eine Betriebsanalyse mit anschließenden jährlichen Betreuungsbesuchen angeboten.
    UNASSIGNED: Bis am Ende des 5. Projektjahres sind insgesamt 1155 Tierhalter dem Projekt beigetreten. Die Klauengesundheitsdaten von 149753 Klauenpflegen auf Tierebene wurden gespeichert und 176 Besuche und Analysen von Betrieben mit Klauengesundheitsproblemen durchgeführt. Ein Gesundheitskonzept für mechanisch-metabolisch assoziierte Klauenprobleme wurde erarbeitet und erfolgreich etabliert. Die Biosicherheitsmaßnahmen anlässlich der Klauenpflege wurden analysiert und eine Broschüre mit Empfehlungen für Klauenpfleger erarbeitet. Risikofaktoren für das Vorkommen von Dermatitis Digitalis in Milchviehbetrieben wurden identifiziert. Die Prävalenz von Alarmerkrankungen ist in den Projektjahren 2 bis 4 bei den beteiligten Betrieben signifikant gesunken.
    UNASSIGNED: Die wissenschaftliche Projektbegleitung erwies sich als äußerst sinnvoll, da der Projektfortschritt kontinuierlich verfolgt und neue Fragestellungen zeitnah angegangen werden konnten. Digital erfasste Befunde während der Betriebsklauenpflege sind essenziell für die Überwachung und Verbesserung der Klauengesundheit.
    UNASSIGNED: Die Beschreibung und kritische Beurteilung der Vorgehensweise kann von anderen Konsortien, welche ein ähnliches Projekt planen, genutzt werden.
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  • 文章类型: Journal Article
    背景:足痛可能是患者的重大负担。定制足部矫形器(CFO)一直是足部疼痛治疗和改善足部功能的主要方法。然而,关于足病医生处方首席财务官的经验或患者使用足部矫形器(FOs)的经验知之甚少,包括首席财务官,脚痛。
    方法:2022年11月,在一家私人足病诊所中,与三名FOs用户(女性=2和男性=1)进行了焦点小组(FG)讨论。该小组代表来自当地普通人群的非专家,这些人患有现有或先前的脚痛,他们亲自使用过非处方药FOs或CFO。2022年12月,还与五名肌肉骨骼(MSK)专业足病医生(女性=2,男性=3)进行了在线FG讨论。该小组代表具有足部生物力学专业知识和CFO提供临床经验的足病医生。记录了FG讨论,分别持续了49和57分钟。转录数据是手动编码的,并进行了专题分析,以确定所收集数据中的模式。
    结果:患者FG的参与者详细介绍了处方过程和CFO的混合经验,有报道称他们的处方参与/投入有限,需要频繁的调整和高昂的成本。对鞋类选择的影响,还强调了CFO在不同类型的鞋子和技术中的可复制性和可转移性,以帮助设计。在FG足病医生中,对设计和制造过程缺乏信心,处方形式语言,与制造商的关系和沟通建设,发布的CFO的可变性以及在CFO规定中对学生进行更好教育的需求成为关键主题。
    结论:患者和足病医生对CFO的规定有相似的看法,即与制造商的沟通不畅,导致对规定的CFO不满,从而对患者体验产生负面影响。足病医生呼吁在注册阶段接受更多教育,以增加新的足病医生在CFO设计和制造方面的知识,并与制造公司更好地合作。
    BACKGROUND: Foot pain can be a significant burden for patients. Custom foot orthoses (CFOs) have been a mainstay in podiatry treatment for foot pain management and improving foot function. However, little is known about podiatrists\' experience of prescribing CFOs or patient experience of using foot orthoses (FOs), including CFOs, for foot pain.
    METHODS: A focus group (FG) discussion with three FOs users (Female = 2 and Male = 1) was conducted in November 2022 within a private podiatry practice. This group represented non-experts from the general local population of individuals with existing or previous foot pain who have personally experienced using either over-the-counter FOs or CFOs. An online FG discussion with five musculoskeletal (MSK) specialist podiatrists (Female = 2 and Male = 3) was also conducted in December 2022. This group represented podiatrists with specialist knowledge in foot biomechanics and clinical experience in CFO provision. The FG discussions were recorded and lasted 49 and 57 min respectively. Transcribed data was manually coded, and a thematic analysis was undertaken to identify patterns within the collected data.
    RESULTS: The participants in the patient FG detailed mixed experiences of the prescription process and CFOs received, with reports of limited involvement/input in their prescription, the need for frequent adjustments and high costs. The impact on footwear choices, replicability and transferability of CFOs into different types of shoes and technologies to aid design were also highlighted. In the podiatrist FG, lack of confidence in design and manufacture processes, prescription form language, relationship and communication building with manufacturers, variability in the CFOs issued and the need for better student education in CFO provision emerged as key themes.
    CONCLUSIONS: Patients and podiatrists shared similar views on CFO provision, namely poor communication with manufacturers leading to dissatisfaction with the CFOs prescribed causing negative impacts on patient experiences. Podiatrists called for greater education at registration level to increase new graduate podiatrist knowledge in CFO design and manufacture and better collaboration with manufacturing companies.
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  • 文章类型: Journal Article
    我们使用有限元分析研究了用于近端指间关节(PIPJ)关节固定术(PIPJA)的新型髓内植入物的机械应力分布,以通过手术矫正影响20%人口的爪锤趾畸形。在根据36岁男性患者的爪趾图像对足部骨骼进行几何重建后,放置了两个植入物,在虚拟模型中,在步态的脚趾离地阶段,在第二至第四HT的PIPJ内植入了一个中性植入物(NI)和另一个10°角度(10°AI),并将结果与非手术足(NSF)的结果进行了比较。与NSF(59.44MPa;p<0.001)相比,在近端指骨(PP)(45.83MPa)上使用NI降低的拉伸应力对第二脚趾进行PIPJA。使用10°AI时,同一脚趾的PP和中指骨(MP)的拉伸应力要高得多,测量147.58和160.58MPa,分别,与NSF中相应接头的59.44和74.95MPa相比(所有p<0.001)。对于压缩应力也发现了类似的结果。与NSF(-113.23MPa)和10°Al(-142MPa)相比,NI降低了第二PP(-65.12MPa)处的压缩应力(所有p<0.001)。当使用NI相对于10°AI时,植入物内的vonMises应力也显著较低(p<0.001)。因此,我们不建议使用10°AI执行PIPJA,因为应力集中主要在第二个PP和MP处增加,这可能会促进植入物的破损。
    We used finite element analysis to study the mechanical stress distribution of a new intramedullary implant used for proximal interphalangeal joint (PIPJ) arthrodesis (PIPJA) to surgically correct the claw-hammer toe deformity that affects 20% of the population. After geometric reconstruction of the foot skeleton from claw toe images of a 36-year-old male patient, two implants were positioned, in the virtual model, one neutral implant (NI) and another one 10° angled (10°AI) within the PIPJ of the second through fourth HT during the toe-off phase of gait and results were compared to those derived for the non-surgical foot (NSF). A PIPJA was performed on the second toe using a NI reduced tensile stress at the proximal phalanx (PP) (45.83 MPa) compared to the NSF (59.44 MPa; p < 0.001). When using the 10°AI, the tensile stress was much higher at PP and middle phalanges (MP) of the same toe, measuring 147.58 and 160.58 MPa, respectively, versus 59.44 and 74.95 MPa at corresponding joints in the NSF (all p < 0.001). Similar results were found for compressive stresses. The NI reduced compressive stress at the second PP (-65.12 MPa) compared to the NSF (-113.23 MPa) and the 10°AI (-142 MPa) (all p < 0.001). The von Mises stresses within the implant were also significantly lower when using NI versus 10°AI (p < 0.001). Therefore, we do not recommend performing a PIPJA using the 10°AI due to the increase in stress concentration primarily at the second PP and MP, which could promote implant breakage.
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  • 文章类型: Journal Article
    来自干骨样本的数据,从解剖或考古收藏中收集,可以提高有关脚骨附件的知识,包括患病率,尺寸,形状和侧向性,这在不同的研究领域是有用的,从医学到生物考古学。在本研究中,六个附属脚骨的患病率(OsTrigonum,跟骨,附属舟骨,osvesalianum,在486名个体(226名女性,260名男性)来自科英布拉识别骨骼收藏(CISC)。最常见的副骨是三角骨(9.9%;48/485)和跟骨(6.0%;29/486),而最不常见的是OSsustentaculum(0.4%;2/486)。没有观察到性别差异。所有的副骨更经常发生在单侧,除了附属的舟骨,在大多数情况下,双边发生。Os三角的单侧表达,跟骨secundarium和osvesalianum主要在右脚。1.7%的个体(8/486)记录到副脚骨的同时出现,最常见的是三角骨和跟骨的组合。这项研究强调了对参考骨骼集合进行研究的相关性,以便全面了解脚部的解剖变化。这种理解对于临床环境中的准确诊断和成功治疗至关重要。以及建立生物考古学和法医人类学领域的人口比较标准。
    Data from dry bone samples, collected from anatomical or archaeological collections, can improve the knowledge regarding accessory foot bones, including prevalence, size, shape and laterality, that can be useful in disparate fields of research, from medicine to bioarcheology. In the present study, the prevalence of six accessory foot bones (os trigonum, calcaneus secundarium, accessory navicular bone, os vesalianum, os sustentaculum and os intermetatarseum) was assessed in a sample of 486 individuals (226 females, 260 males) from the Coimbra Identified Skeletal Collection (CISC). The most frequent accessory bones are os trigonum (9.9%; 48/485) and calcaneus secundarium (6.0%; 29/486), while the most uncommon is os sustentaculum (0.4%; 2/486). No sex differences were observed. All accessory bones occur more often unilaterally, with the exception of the accessory navicular bone that, in the majority of cases, occurs bilaterally. The unilateral expression of os trigonum, calcaneus secundarium and os vesalianum was mostly in the right foot. The co-occurrence of accessory foot bones was recorded in 1.7% of the individuals (8/486), and the combinations of os trigonum and calcaneus secundarium were the most frequently observed. This research emphasizes the relevance of conducting studies on reference skeletal collections in order to gain a comprehensive understanding of anatomical variations in the foot. This understanding is crucial for accurate diagnoses and successful treatment in clinical settings, as well as for establishing population comparison standards in the fields of bioarchaeology and forensic anthropology.
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  • 文章类型: Journal Article
    进行该试验是为了评估用微藻粉代替豆粕的效果(MM;Arthrospiraspp。)在种植和整理阶段对生产性能的影响,足垫皮炎(FPD)的发生,胸肉质量,肉鸡氨基酸消化率和血浆代谢组学特征。将一千只日龄的罗斯308只雄性雏鸡分为5个实验组(8个重复,25只鸟/只):CON,在整个试验过程中(0-41d)饲喂商业大豆基饮食;F3和F6,饲喂CON饮食至28d,然后饲喂30或60gMM/kg的整理饮食(29-41d),分别;GF3和GF6,接受CON饮食至14d,然后在15至41d的饮食中含有30或60gMM/kg,分别。所有饮食都是等能量的并且具有相似的氨基酸谱。在每个饲喂阶段结束时,以笔为基础记录生长性能,并在41d时确定表观回肠氨基酸消化率。对所有加工过的鸟类评估足垫皮炎的发生率,同时收集乳腺和血浆样品进行肉质和代谢组学分析(质子核磁共振-1H-NMR)。在41天,CON组的体重高于F6和GF6组(2,541vs.2,412vs.2,384g,分别;P<0.05)。总的来说,GF6组表现出最高的饲料转化率,而F3与CON相比没有显着差异(1.785vs.1.810vs.1.934克饲料/克增重,分别为CON,F3和GF6;P<0.01)。各组之间发生FPD的发生率和风险相似。MM给药增加了胸肉黄度,降低了氨基酸消化率(P<0.001)。1H-NMR分析显示某些循环代谢物水平的变化,包括组氨酸,精氨酸和肌酸,发挥重要的代谢作用。总的来说,这些发现有助于扩展有关节旋体属物种使用的知识。作为肉鸡日粮中的蛋白质来源。
    This trial was conducted to evaluate the effects of replacing soybean meal with microalgae meal (MM; Arthrospira spp.) during grower and finisher phases on productive performance, footpad dermatitis (FPD) occurrence, breast meat quality, amino acid digestibility and plasma metabolomics profile of broiler chickens. One thousand day-old Ross 308 male chicks were divided into 5 experimental groups (8 replicates, 25 birds/each): CON, fed a commercial soybean-based diet throughout the trial (0-41 d); F3 and F6, fed the CON diet up to 28 d of age and then a finisher diet (29-41 d) with either 30 or 60 g MM/kg, respectively; and GF3 and GF6, receiving CON diet until 14 d and then diets containing 30 or 60 g MM/kg from 15 to 41 d, respectively. All diets were iso-energetic and with a similar amino acid profile. Growth performances were recorded on a pen basis at the end of each feeding phase and apparent ileal amino acid digestibility was determined at 41 d. Footpad dermatitis occurrence was assessed on all processed birds, while breast and plasma samples were collected for meat quality and metabolomics analysis (proton nuclear magnetic resonance - 1H-NMR). At 41 d, CON group showed higher body weight than F6 and GF6 ones (2,541 vs. 2,412 vs. 2,384 g, respectively; P < 0.05). Overall, GF6 group exhibited the highest feed conversion ratio, while F3 did not present significant differences compared to CON (1.785 vs. 1.810 vs. 1.934 g feed/g gain, respectively for CON, F3 and GF6; P < 0.01). The occurrence and the risk of developing FPD were similar among groups. MM administration increased breast meat yellowness and reduced amino acid digestibility (P < 0.001). The 1H-NMR analysis revealed variations in the levels of some circulating metabolites, including histidine, arginine and creatine, which play important metabolic roles. Overall, these findings can contribute to expand the knowledge about the use of Arthrospira spp. as protein source in broiler diets.
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  • 文章类型: Journal Article
    跑步高跟鞋是最不平衡的,导致软管性能不佳。已经执行了几个纠正鞋帮协议,但结果尚未一致。在这项研究中,我们提出了一种替代的修剪协议,以管理不足的高跟鞋:在常规鞋之前进行战略性的手掌修剪。因此,本研究的目的是调查在传统鞋跟之前进行战略性手掌修剪的潜力,以管理鞋跟不足的马匹的蹄部失衡。
    将11种受影响的马分为对照组(5种马,有14种蹄有缺陷)和实验组(6种马,有16种蹄有缺陷)。实验组在常规鞋前进行战略性手掌修剪,而对照马匹在传统的鞋子之前接受了定期的修剪。背蹄壁角(DHWA)/后跟角(HA)比率,脚跟-灯泡距离,之前确定了六条指示太阳能表面尺寸的平行线,在5、10、15、20、25和30周的不同修剪方案之后。仅在实验马中测量手掌修剪距离。
    观察到DHWA/HA比率和太阳表面尺寸的分组时间相互作用。在足跟球距离中观察到组和时间的单独影响。仅在实验组的马中,在25-30周时检测到蹄构象的改变,包括DHWA/HA比率的下降,脚跟-灯泡距离,和手掌修剪距离,与修剪的蹄的手掌宽度增加相吻合。
    不同的修剪方案对蹄构象产生不同的影响。因此,战术补救修剪可能会控制脚跟不足的马的蹄形不良。
    UNASSIGNED: Underrun heels are among the most hoof imbalances, causing poor performance in hoses. Several corrective shoeing protocols have been performed, but the outcomes have yet to be consistent. In this study, we proposed an alternative trimming protocol for managing underrun heels: strategic palmar trimming before conventional shoeing. Therefore, the current study aimed to investigate the potential of strategic palmar trimming before conventional shoeing for managing hoof imbalance in horses with underrun heels.
    UNASSIGNED: Eleven affected horses were divided into control (5 horses with 14 defective hooves) and experimental (6 horses with 16 defective hooves) groups. The experimental group underwent strategic palmar trimming before conventional shoeing, while the control horses received regular trimming before traditional shoeing. Dorsal hoof wall angle (DHWA)/heel angle (HA) ratios, heel-bulb distance, and six parallel lines indicating solar surface dimension were determined before, and after 5, 10, 15, 20, 25, and 30 weeks of the different trimming protocols. Palmar trimming distance was only measured in experimental horses.
    UNASSIGNED: A group-by-time interaction was observed for DHWA/HA ratios and solar surface dimension. Separate effects for group and time were observed in the heel-bulb distance. A modification in hoof conformation was detected at 25-30 weeks only in horses in the experimental group, including decreases in DHWA/HA ratio, heel-bulb distance, and palmar trimming distance, coinciding with an increase in palmar width of trimmed hooves.
    UNASSIGNED: Different trimming protocols produced a different effect on hoof conformation. Therefore, tactical remedial trimming can potentially control poor hoof conformation in horses with underrun heels.
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    文章类型: Journal Article
    目的:比较胫骨后肌腱锚钉重建与传统Kidner术式治疗副舟骨综合征的疗效。
    方法:对我院2018-2021年收治的40例诊断为副舟骨综合征的青少年运动员进行回顾性分析。其中,20例患者接受改良的Kidner手术锚钉重建胫骨后肌腱(实验组),其余20例患者采用传统的Kidner手术治疗(对照组)。定期随访评价足部症状缓解程度及功能恢复情况。
    结果:所有患者术后随访12~24个月,平均随访时间:18.6±3.7。在最后一次随访中,与术前状态相比,患足的功能和症状缓解存在显着差异。实验组平均手术时间为52.10±3.41分钟,明显短于对照组的61.25±2.75分钟。实验组恢复正常活动的平均时间为12.65±1.23周,对照组为15.25±1.16周。
    结论:改良的Kidner手术与传统的Kidner手术相比,患者满意度更高。这归因于其持续时间较短,减少创伤,更快地恢复正常活动。
    OBJECTIVE: To compare the effects of anchor reconstruction of posterior tibial tendon with the traditional Kidner\'s procedure for accessory navicular bone syndrome.
    METHODS: A retrospective analysis was conducted on 40 young athletes diagnosed with accessory navicular bone syndrome who were admitted to our hospital from 2018 to 2021. Among them, 20 patients underwent the modified Kidner procedure for the anchor reconstruction of the posterior tibial tendon (Experimental group), while the remaining 20 patients were treated with the traditional Kidner\'s procedure (Control group). Regular follow-ups were conducted to evaluate the degree of relief of foot symptoms and functional recovery.
    RESULTS: All patients were followed up for 12 to 24 months (mean duration: 18.6±3.7) after the operation. At the last follow-up, significant differences were observed in the function and symptom relief of the affected foot compared to the preoperative state. The experimental group had a mean operation time of 52.10 ± 3.41 minutes, significantly shorter than the control group\'s 61.25 ± 2.75 minutes. The mean time to return to normal activity was 12.65 ± 1.23 weeks for the experimental group, compared to 15.25 ± 1.16 weeks for the control group.
    CONCLUSIONS: The modified Kidner procedure demonstrates a higher patient satisfaction rate compared to the traditional Kidner procedure. This is attributed to its shorter duration, reduced trauma, and quicker recovery of normal activity.
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  • 文章类型: Journal Article
    足皮炎,也称为密螺旋体相关蹄病(TAHD),对美国西北部的麋鹿(Cervuscanadensis)种群提出了重大挑战,与密螺旋体属。始终与病变发展有关。然而,从这些病变中鉴定特定物种的密螺旋体菌株受到其培养不适应和有限的基因组信息的阻碍。这项研究利用鸟枪测序,在硅基因组重建,和比较基因组学作为一种独立于培养的方法,用于从接受TAHD实验挑战的圈养麋鹿的皮肤刮擦样品中鉴定宏基因组组装的密螺旋体基因组(MATG)。基因组分析揭示了10个新的MATGs,其中6个代表与麋鹿足皮炎相关的新基因组物种,4个代表先前鉴定的物种-螺旋体和螺旋体。重要的是,在这项研究中发现的新的基因组特征在诊断为TAHD的自由范围麋鹿的活检样本中始终检测到,表明潜在的病因关联。MATG与其他密螺旋体基因组的比较代谢谱显示出独特的代谢谱,表明这些新鉴定的基因组物种的潜在宿主适应性或地理独特性。新的密螺旋体基因组的发现增强了我们对足皮炎发病机理的理解,并为开发改进的分子监测工具以监测和管理自由放养麋鹿的疾病奠定了基础。重要密螺旋体属。在自由放养麋鹿足皮炎的发展中起重要作用;然而,由于培养不适应和基因组信息有限,从足皮炎皮损中检测螺旋体的物种特异性具有挑战性.该研究利用shot弹枪测序和计算机基因组重建来鉴定患有足皮炎的麋鹿的新型密螺旋体基因组。新型密螺旋体物种的发现为开发用于监测麋鹿足皮炎的分子诊断和流行病学工具开辟了新的途径。这些发现极大地增强了我们对密耳科财团基因组景观的理解,同时为麋鹿种群中新兴的足皮炎的病因和发病机理提供了宝贵的见解。
    Pododermatitis, also known as treponeme-associated hoof disease (TAHD), presents a significant challenge to elk (Cervus canadensis) populations in the northwestern USA, with Treponema spp. consistently implicated in the lesion development. However, identifying species-specific Treponema strains from these lesions is hindered by its culture recalcitrance and limited genomic information. This study utilized shotgun sequencing, in silico genome reconstruction, and comparative genomics as a culture-independent approach to identify metagenome-assembled Treponema genomes (MATGs) from skin scraping samples collected from captive elk experimentally challenged with TAHD. The genomic analysis revealed 10 new MATGs, with 6 representing novel genomospecies associated with pododermatitis in elk and 4 corresponding to previously identified species-Treponema pedis and Treponema phagedenis. Importantly, genomic signatures of novel genomospecies identified in this study were consistently detected in biopsy samples of free-ranging elk diagnosed with TAHD, indicating a potential etiologic association. Comparative metabolic profiling of the MATGs against other Treponema genomes showed a distinct metabolic profile, suggesting potential host adaptation or geographic uniqueness of these newly identified genomospecies. The discovery of novel Treponema genomospecies enhances our understanding of the pathogenesis of pododermatitis and lays the foundation for the development of improved molecular surveillance tools to monitor and manage the disease in free-ranging elk.IMPORTANCETreponema spp. play an important role in the development of pododermatitis in free-ranging elk; however, the species-specific detection of Treponema from pododermatitis lesions is challenging due to culture recalcitrance and limited genomic information. The study utilized shotgun sequencing and in silico genome reconstruction to identify novel Treponema genomospecies from elk with pododermatitis. The discovery of the novel Treponema species opens new avenues to develop molecular diagnostic and epidemiologic tools for the surveillance of pododermatitis in elk. These findings significantly enhance our understanding of the genomic landscape of the Treponemataceae consortium while offering valuable insights into the etiology and pathogenesis of emerging pododermatitis in elk populations.
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  • 文章类型: Journal Article
    强直性脊柱炎(AS)是一种慢性,炎症,和自身免疫性疾病。这种情况主要影响轴向骨骼,并直接累及足部,如跟腱炎或足底筋膜受累。
    本研究旨在调查与没有AS的对照组相比,足部健康对AS患者生活质量的影响。
    招募了112名受试者的样本,平均年龄46.80±10.49岁,分为两组:56例AS患者(病例)和56例无AS患者(对照)。收集了人口统计数据,并记录在足部健康状况问卷领域获得的分数。
    在参与者中,27.79%(N=30)为男性,73.21%(N=82)为女性。该组的平均年龄为46.80±10.49。在足功能领域发现了显着差异(p<0.05),脚痛,鞋类,整体足部健康,一般与健康相关的身体活动,AS组和对照组之间的社会能力。
    患有AS的人的生活质量下降,如他们的足部健康状况问卷得分所示。
    UNASSIGNED: Ankylosing spondylitis (AS) is a chronic, inflammatory, and autoimmune disease. This condition primarily affects the axial skeleton and presents direct foot involvement, such as Achilles enthesitis or plantar fascia involvement.
    UNASSIGNED: This study aimed to investigate the impact of foot health on the quality of life of individuals with AS compared to a control group without AS.
    UNASSIGNED: A sample of 112 subjects was recruited, with a mean age of 46.80 ± 10.49 years, divided into two groups: 56 individuals with AS (cases) and 56 individuals without AS (controls). Demographic data were collected, and the scores obtained in the Foot Health Status Questionnaire domains were recorded.
    UNASSIGNED: Of the participants, 27.79% (N = 30) were men and 73.21% (N = 82) were women. The mean age in the group was 46.80 ± 10.49. Significant differences (p < 0.05) were found in the domains of foot function, foot pain, footwear, overall foot health, general health-related physical activity, and social capacity between the AS group and the control group.
    UNASSIGNED: Individuals with AS exhibited a decreased quality of life, as indicated by their Foot Health Status Questionnaire scores.
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  • 文章类型: Journal Article
    这项研究的目的是描述流行病学,在英格兰各地儿童和年轻人(CYP)的足部和脚踝问题初级保健中的演示和医疗保健使用。我们使用临床实践研究数据链Aurum数据库的数据进行了一项基于人群的队列研究。来自英格兰一般做法的匿名电子健康记录数据库。在2015年1月至2021年12月期间,所有年龄为0-18岁的CYP向其全科医生提供的足部和/或脚踝问题的数据均被访问。计算咨询率,并用于估计平均实践中的咨询次数。分层泊松回归估计了社会人口统计学组之间的相对咨询率,逻辑回归评估了与重复咨询相关的因素。共有416,137名患者发生了687,753足和踝关节事件,其中大多数被归类为“肌肉骨骼”(34%)和“未指定疼痛”(21%)。2018年,10-14岁男性的咨询率达到峰值,为每10,000名患者年601次。平均实践每年可能会观察132(95%CI110至155)咨询。在先前诊断包括幼年关节炎的患者中,重复咨询的几率更高(OR1.73,95%CI1.48至2.03)。结论:CYP对足部和踝关节问题的咨询率很高,尤其是10至14岁的男性。这些数据可以为服务提供提供信息,以确保CYP获得适当的卫生专业人员进行准确的诊断和治疗。已知:•足部和踝关节问题可对儿童和年轻人(CYP)的健康相关生活质量具有相当大的影响。•描述CYP中脚和脚踝问题的性质和频率的数据有限。新增内容:•与其他年龄组相比,年龄在10至14岁的CYP中,足踝会诊在英语全科中的比例更高,男性高于女性。•未指明的诊断和重复咨询的比例很高,这表明在基于社区的医疗保健环境中,全科医生和专职医疗专业人员之间需要更大的整合。
    The aim of this research was to describe the epidemiology, presentation and healthcare use in primary care for foot and ankle problems in children and young people (CYP) across England. We undertook a population-based cohort study using data from the Clinical Practice Research Datalink Aurum database, a database of anonymised electronic health records from general practices across England. Data was accessed for all CYP aged 0-18 years presenting to their general practitioner between January 2015 and December 2021 with a foot and/or ankle problem. Consultation rates were calculated and used to estimate numbers of consultations in an average practice. Hierarchical Poisson regression estimated relative rates of consultations across sociodemographic groups and logistic regression evaluated factors associated with repeat consultations. A total of 416,137 patients had 687,753 foot and ankle events, of which the majority were categorised as \"musculoskeletal\" (34%) and \"unspecified pain\" (21%). Rates peaked at 601 consultations per 10,000 patient-years among males aged 10-14 years in 2018. An average practice might observe 132 (95% CI 110 to 155) consultations annually. Odds for repeat consultations were higher among those with pre-existing diagnoses including juvenile arthritis (OR 1.73, 95% CI 1.48 to 2.03).    Conclusions: Consultations for foot and ankle problems were high among CYP, particularly males aged 10 to 14 years. These data can inform service provision to ensure CYP access appropriate health professionals for accurate diagnosis and treatment. What is Known: • Foot and ankle problems can have considerable impact on health-related quality of life in children and young people (CYP). • There is limited data describing the nature and frequency of foot and ankle problems in CYP. What is New: • Foot and ankle consultations were higher in English general practice among CYP aged 10 to 14 years compared to other age groups, and higher among males compared to females. • The high proportion of unspecified diagnoses and repeat consultations suggests there is need for greater integration between general practice and allied health professionals in community-based healthcare settings.
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