■要使用有限元(FE)分析来评估虹膜和前房的哪些形态学和生物力学因素更有可能影响瞳孔扩张过程中的角度变窄。
■该研究由1344个角膜模型组成,巩膜,镜头,和虹膜来模拟瞳孔扩张。对于每个模型,我们改变了以下参数:前房深度(ACD=2-4毫米)和前房宽度(ACW=10-12毫米),虹膜凸度(IC=0-0.3mm),虹膜厚度(IT=0.3-0.5mm),刚度(E=4-24kPa),和泊松比(v=0-0.3)。我们评估了每个参数从基线到扩张的(△周)和最终扩张角(周f)的变化。
■最终的扩张角随着ACD的减小而减小(彡f=53.4°±12.3°~21.3°±14.9°),较小的ACW(清洗f=48.2°±13.5°~26.2°±18.2°),较大的IT(清洗f=52.6°±12.3°~24.4°±15.1°),较大的IC(咨询f=45.0°±19.2°~33.9°±16.5°),较大的E(咨询f=40.3°±17.3°~37.4°±19.2°),v较大(咨询f=42.7°±17.7°~34.2°±18.1°)。角度变化随ACD增大而增大(△浴=9.37°±11.1°~15.4°±9.3°),较小的ACW(△运=7.4°±6.8°至16.4°±11.5°),较大的IT(△运=5.3°±7.1°~19.3°±10.2°),较小的IC(△运=5.4°±8.2°至19.5°±10.2°),较大的E(△运=10.9°±12.2°~13.1°±8.8°),v较大(△槽=8.1°±9.4°~16.6°±10.4°)。
■虹膜形态(IT和IC)及其先天生物力学行为(E和V)对影响虹膜在扩张过程中变形的方式至关重要,前房生物测定(ACD和ACW)降低进一步加剧了房角闭合。
UNASSIGNED: To use finite element (FE) analysis to assess what morphologic and biomechanical factors of the iris and anterior chamber are more likely to influence angle narrowing during pupil dilation.
UNASSIGNED: The study consisted of 1344 FE models comprising the cornea, sclera, lens, and iris to simulate pupil dilation. For each model, we varied the following parameters: anterior chamber depth (ACD = 2-4 mm) and anterior chamber width (ACW = 10-12 mm), iris convexity (IC = 0-0.3 mm), iris thickness (IT = 0.3-0.5 mm), stiffness (E = 4-24 kPa), and Poisson\'s ratio (v = 0-0.3). We evaluated the change in (△∠) and the final dilated angles (∠f) from baseline to dilation for each parameter.
UNASSIGNED: The final dilated angles decreased with a smaller ACD (∠f = 53.4° ± 12.3° to 21.3° ± 14.9°), smaller ACW (∠f = 48.2° ± 13.5° to 26.2° ± 18.2°), larger IT (∠f = 52.6° ± 12.3° to 24.4° ± 15.1°), larger IC (∠f = 45.0° ± 19.2° to 33.9° ± 16.5°), larger E (∠f = 40.3° ± 17.3° to 37.4° ± 19.2°), and larger v (∠f = 42.7° ± 17.7° to 34.2° ± 18.1°). The change in angles increased with larger ACD (△∠ = 9.37° ± 11.1° to 15.4° ± 9.3°), smaller ACW (△∠ = 7.4° ± 6.8° to 16.4° ± 11.5°), larger IT (△∠ = 5.3° ± 7.1° to 19.3° ± 10.2°), smaller IC (△∠ = 5.4° ± 8.2° to 19.5° ± 10.2°), larger E (△∠ = 10.9° ± 12.2° to 13.1° ± 8.8°), and larger v (△∠ = 8.1° ± 9.4° to 16.6° ± 10.4°).
UNASSIGNED: The morphology of the iris (IT and IC) and its innate biomechanical behavior (E and v) were crucial in influencing the way the iris deformed during dilation, and angle closure was further exacerbated by decreased anterior chamber biometry (ACD and ACW).