■比较早期家族性渗出性玻璃体视网膜病变(FEVR)患者与健康对照组之间的生物特征。
这项病例对照研究包括50只1-2期FEVR眼和50只按年龄匹配的对照眼,性别和球面当量(SE)。生物参数,包括轴向长度(AL),白色至白色直径(WTW),中央角膜厚度(CCT),前房深度(ACD),透镜厚度(LT),瞳孔直径,玻璃体腔深度,前后角膜表面曲率半径(ACR和PCR),使用IOLMaster700测量前晶状体表面曲率半径(ALR)和后晶状体表面曲率半径,并使用配对t检验在病例和对照组之间进行比较.在病例和对照中,使用Pearson相关系数(r)评估SE和生物特征测量之间的相关性。
FEVR病例和配对对照的平均年龄均为7.6岁,48%为女性,平均SE为-5.3D(80%近视)。与对照组相比,FEVR眼睛有较小的AL(P=0.009),WTW(P=0.001),ACD(P<0.001),和ALR(P=0.03),但较大的CCT(P=0.02)和LT(P=0.01)。在FEVR眼中,SE与AL呈负相关(r=-0.79,P<0.001),与ACR(r=0.29,P=0.04)和PCR(r=0.33,P=0.02)呈正相关,而在控制中,SE与AL(r=-0.82,P<0.001)、LT(r=-0.34,P=0.02)呈负相关。与ALR呈正相关(r=0.29,P=0.04)。
■FEVR早期患者表现出独特的眼睛形态,类似于眼部发育停滞,这可能有助于开发FEVR的筛查和早期检测工具。在FEVR患者中,近视非常普遍,并且与角膜曲率增加显著相关。
To compare biometric characteristics between patients with early-stage familial exudative vitreoretinopathy (FEVR) and healthy controls.
This case-control study included 50 FEVR eyes in stage 1-2 and 50 control eyes matched by age, gender and spherical equivalent (SE). Biometric parameters including axial length (AL), white-to-white diameter (WTW), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), pupil diameter, vitreous chamber depth, anterior and posterior corneal surface curvature radius (ACR and PCR), anterior lens surface curvature radius (ALR) and posterior lens surface curvature radius were measured using IOLMaster 700 and compared between cases and controls using paired t-test. Correlations between SE and biometric measures were assessed using Pearson correlation coefficient (r) in cases and controls.
Both FEVR cases and matched controls had a mean age of 7.6 years, 48% female and mean SE of -5.3 D (80% myopia). Compared to controls, FEVR eyes had smaller AL (P = 0.009), WTW (P = 0.001), ACD (P < 0.001), and ALR (P = 0.03), but larger CCT (P = 0.02) and LT (P = 0.01). In FEVR eyes, SE was negatively correlated with AL (r = -0.79, P < 0.001), positively correlated with ACR (r = 0.29, P = 0.04) and PCR (r = 0.33, P = 0.02), whereas in controls, SE was negatively correlated with AL (r = -0.82, P < 0.001) and LT (r = -0.34, P = 0.02), positively correlated with ALR (r = 0.29, P = 0.04).
Patients at early stage of FEVR exhibited a unique eye morphology resembling ocular development arrest, which may help to develop screening and early detection tools for FEVR. In FEVR patients, myopia is very prevalent and significantly associated with corneal curvature increase.