代谢性疾病发病率和患病率的增加,比如糖尿病,肥胖,代谢综合征,是全世界的健康问题。可以影响线粒体活性的营养策略代表了调节细胞和组织中的能量消耗和能量代谢的新颖而有效的选择,并且可以用作代谢相关疾病的辅助治疗。膳食生物活性化合物也被称为“食品生物活性物质”已被证明具有多种健康益处并抵消代谢改变。在过去的几年里,一直有报道称,线粒体功能的调节是生物活性化合物依赖性健康改善背后的机制之一.在这次审查中,我们专注于聚会,总结,并讨论支持饮食生物活性化合物对线粒体活性的影响以及这些影响在病理背景下的关系的证据。尽管这里有关于体内和体外作用的证据,需要更多的研究来确定它们在人类中的有效性。
The increase in incidence and prevalence of metabolic diseases, such as diabetes, obesity, and metabolic syndrome, is a health problem worldwide. Nutritional strategies that can impact on mitochondrial activity represent a novel and effective option to modulate energy expenditure and energetic metabolism in cells and tissues and could be used as adjuvant treatments for metabolic-associated disorders. Dietary bioactive compounds also known as \"food bioactives\" have proven to exert multiple health benefits and counteract metabolic alterations. In the last years, it has been consistently reported that the modulation of mitochondrial function represents one of the mechanisms behind the bioactive compounds-dependent health improvements. In this review, we focus on gathering, summarizing, and discussing the evidence that supports the effect of dietary bioactive compounds on mitochondrial activity and the relation of these effects in the pathological context. Despite the evidence presented here on in vivo and in vitro effects, more studies are needed to determine their effectiveness in humans.