背景:芯针活检(CNB)是一种用于术前诊断乳腺肿块的微创手术。人们已经看到,在几年内,CNB似乎正在取代细针穿刺细胞学(FNAC),尽管还没有一项研究最终证明了两者的优越性。
目的:本研究的目的是研究可触及的乳腺病变的细胞组织学谱,并评估FNAC与CNB对乳腺病变的诊断准确性。
方法:该研究是在病理和外科部门进行的横断面研究,在152名患者的1年内。所有患者均接受FNAC和CNB治疗。细胞涂片用May-GrunwaldGiemsa和苏木精染色,并对CNB和切除活检(EB)标本进行伊红染色。参照CNB/手术标本以95%置信区间以百分比计算灵敏度和特异性。使用Kappa统计来比较FNAC与CNB以及CNB与手术标本之间的一致性水平。
结果:共152例患者接受FNAC和CNB治疗。仅104例患者进行了EB治疗。敏感性,特异性,正预测值,负预测值,与随后的组织病理学相关的FNAC和CNB的准确性被发现是(93.40vs.94.06%),(97.50vs.100.00%),(99.00vs.100.00%),(84.78vs.33.33%),和(94.52vs.94.23%),分别。
结论:CNB已经克服了FNAC的缺陷,但CNB不能替代FNAC,但这两种方法是相辅相成的。
BACKGROUND: Core-needle biopsy (CNB) is a minimally invasive procedure used in preoperative diagnosis of breast lumps. It has been seen that in few years, the CNB seems to be replacing the fine-needle aspiration cytology (FNAC), although no study had yet conclusively proved a superiority of one over the other.
OBJECTIVE: The aim of this study was to study the cytohistological spectrum of palpable breast lesions and to evaluate the diagnostic accuracy of FNAC versus CNB for breast lesions.
METHODS: The study was a cross-sectional study conducted in the Department of Pathology and Surgery, over a period of 1 year in 152 patients. All the patients were subjected to FNAC and CNB. Cytosmears were stained with May-Grunwald Giemsa and hematoxylin and eosin was done on CNB and excision biopsy (EB) specimens. Sensitivity and specificity were calculated in percentage with 95% confidence interval with reference to CNB/surgical specimens. Kappa statistics were used to compare the level of agreement between FNAC versus CNB and CNB versus surgical specimens.
RESULTS: A total of 152 patients were taken for FNAC and CNB. EB was performed in only 104 patients. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of FNAC verses CNB in correlation with subsequent histopathology were found to be (93.40 vs. 94.06%), (97.50 vs. 100.00%), (99.00 vs. 100.00%), (84.78 vs. 33.33%), and (94.52 vs. 94.23%), respectively.
CONCLUSIONS: CNB has overcome the pitfall of FNAC but CNB cannot replace FNAC but both procedures are complementary to each other.