目的:急性中心性浆液性脉络膜视网膜病变(ACSCR)是一种以视力下降为特征的疾病,黄斑增厚,和视网膜下的水肿。尽管这种疾病的潜在机制尚未完全了解,氧化应激被认为是一个关键的危险因素。本研究的目的是通过调查循环三甲胺N-氧化物(TMAO)的水平来阐明ACSCR的病理生理学,phoenixin(PNX),alarin(ALA),ACSCR患者中的spexin(SPX)分子。
方法:该研究包括30名ACSCR患者和30名健康个体作为对照。使用光学相干断层扫描(OCT)成像诊断ACSCR。在禁食过夜后,从所有参与者收集5mL血液样品。TMAO的水平,PNX,ALA,使用ELISA方法测量血液样品中的SPX和SPX。
结果:发现与对照组相比,ACSCR患者的视力显着降低(<0.05),黄斑厚度增加(<0.05)。此外,TMAO,PNX,ACSCR患者ALA水平明显高于ACSCR患者(<0.05),而SPX水平明显低于对照组(<0.05)。在ACSCR患者中,黄斑厚度与TMAO呈正相关,PNX,和ALA;有,然而,与SPX呈负相关。此外,视力与TMAO呈负相关,PNX,还有ALA,而SPX水平随着视力下降而下降。
结论:这些结果证明了TMAO之间的相关性,PNX,ALA,ACSCR患者的SPX水平及其视力和黄斑厚度。鉴于这些分子在ACSCR的病理生理学中的作用,他们有希望作为潜在的诊断,治疗性的,以及未来的后续标记。
Acute central serous
chorioretinopathy (ACSCR) is a condition characterized by decreased visual acuity, macular thickening, and edema under the retinal layer. Although the underlying mechanisms of the disease are not fully understood, oxidative stress is considered to be a critical risk factor. The aim of this study was to shed light on the pathophysiology of ACSCR by investigating the levels of circulating trimethylamine N-oxide (TMAO), phoenixin (PNX), alarin (ALA), and spexin (SPX) molecules in ACSCR patients.
The study included 30 ACSCR patients and 30 healthy individuals as controls. ACSCR was diagnosed using optical coherence tomography (OCT) imaging. Five mL blood samples were collected from all participants following overnight fasting. The levels of TMAO, PNX, ALA, and SPX in the blood samples were measured using the ELISA method.
Visual acuity was found to be significantly reduced in ACSCR patients compared to the control group (<0.05), while macular thickness was increased (<0.05). Furthermore, TMAO, PNX, and ALA levels were significantly higher in ACSCR patients (<0.05), while SPX levels were significantly lower compared to the control group (<0.05). In ACSCR patients, there was a positive correlation between macular thickness and TMAO, PNX, and ALA; there was, however, a negative correlation with SPX. Additionally, visual acuity was negatively correlated with TMAO, PNX, and ALA, while SPX levels decreased as visual acuity decreased.
These results demonstrate a correlation between the TMAO, PNX, ALA, and SPX levels of ACSCR patients and their visual acuity and macular thickness. Given the role of these molecules in ACSCR\'s pathophysiology, they hold promise as potential diagnostic, therapeutic, and follow-up markers in the future.