■特发性正常压力脑积水(iNPH)患者,平衡紊乱的特征不如步态相关的特征得到很好的理解。这项研究检查了这些患者在脑脊液敲击试验(CSFTT)后安静站立时姿势稳定性的变化。此外,这项研究探讨了自发性身体摇摆量与步态和执行功能之间的关系。
■所有诊断为iNPH的患者均接受CSFTT。我们在安静站立时评估了他们在测力板上的压力中心(COP)测量值,CSFTT之前和之后。在COP测量之后,我们使用时域和频域分析计算了COP参数,并评估了CSFTT后这些参数的变化.在CSFTT之前,我们评估了定时上行(TUG)和正面评估电池(FAB)。我们调查了CSFTT前COP参数与TUG和FAB得分之间的关系。
■最初共纳入72例iNPH患者,最终纳入了对CSFTT反应积极的56例患者。CSFTT后,通过时域分析观察到COP参数显著改善。这些包括COP的速度(vCOP),COP的均方根(rmsCOP),转向指数,扭矩,和支持基础(BOS),与前CSFTT值相比(p<0.05)。在CSFTT后的COP参数的频域分析中,在0.5Hz以下,前后(AP)和中外侧(ML)方向的功率谱密度(PSD)峰值和平均值均有所下降(p<0.05).此外,TUG分数与vCOP呈正相关,rmsCOP,转向指数,扭矩,BOS,AP和ML方向的峰值和平均PSD值都低于0.5Hz(p<0.05)。FAB分数与vCOP呈负相关,rmsCOP,转向指数,BOS,并且在AP方向上的峰值和平均PSD值均低于0.5Hz(p<0.05)。
■在对CSFTT有反应的iNPH患者中,CSFTT后安静站立时,自发的身体摇摆有所改善。自发摇摆增加与步态和额叶功能受损有关。这可能与iNPH患者的皮质-皮质和皮质-皮质下回路受损有关。
UNASSIGNED: In patients with idiopathic normal pressure hydrocephalus (iNPH), the characteristics of balance disturbance are not as well understood as those related to gait. This study examined changes in postural stability in quiet standing after the cerebrospinal fluid tap test (CSFTT) in these patients. Furthermore, the study explored the relationship between the amount of spontaneous body sway and both gait and executive function.
UNASSIGNED: All patients diagnosed with iNPH underwent CSFTT. We evaluated their center of pressure (COP) measurements on a force plate during quiet standing, both pre- and post-CSFTT. Following the COP measurements, we calculated COP parameters using time and frequency domain analysis and assessed changes in these parameters after CSFTT. At pre-CSFTT, we assessed the Timed Up and Go (TUG) and the Frontal Assessment Battery (FAB). We investigated the relationship between COP parameters and the TUG and FAB scores at pre-CSFTT.
UNASSIGNED: A total of 72 patients with iNPH were initially enrolled, and 56 patients who responded positively to CSFTT were finally included. Post-CSFTT, significant improvements were observed in COP parameters through time domain analysis. These included the velocity of COP (vCOP), root-mean-square of COP (rmsCOP), turn index, torque, and base of support (BOS), compared to the pre-CSFTT values (p < 0.05). In the frequency domain analysis of COP parameters post-CSFTT, there was a decrease in both the peak and average of power spectral density (PSD) values in both the anteroposterior (AP) and mediolateral (ML) directions below 0.5 Hz (p < 0.05). In addition, the TUG scores showed a positive correlation with vCOP, rmsCOP, turn index, torque, BOS, and both the peak and average PSD values in the AP and ML directions below 0.5 Hz (p < 0.05). The FAB scores demonstrated a negative correlation with vCOP, rmsCOP, turns index, BOS, and both peak and average PSD values in the AP direction below 0.5 Hz (p < 0.05).
UNASSIGNED: In patients with iNPH who responded to CSFTT, there was an improvement in spontaneous body sway during quiet standing after CSFTT. Increased spontaneous sway is associated with impaired gait and frontal lobe function. This may be linked to impaired cortico-cortical and cortico-subcortical circuits in patients with iNPH.