■衰老与较高的肌少症患病率相关,肌肉减少性肥胖(SO),增加动脉硬化,可能对发病率和死亡率产生不利影响。这项研究的目的是评估肌少症之间的关系,所以,老年人动脉僵硬度的不同指标。
■共评估了77名住院患者(平均年龄78.68±9.65岁),获取人体测量变量,生化样本,手握测试,和身体成分评估。通过测量颈动脉-股动脉脉搏波速度(cfPWV)来评估动脉僵硬度,中心刚度的代表,和心踝血管指数(CAVI),以及考虑外周动脉。人群分为四个亚组:肥胖,节瘤,所以,和控制。
■CAVI最高(11.31±2.58)见于少肌症患者。SO的cfPWV值最高(15.18±8.44m/s),即使在调整了显著的协变量之后。在多元回归中,SO诊断是cfPWV的重要预测因子(p=0.03,R2=0.20),和肌肉减少症诊断是CAVI的预测因子(p=0.042,R2=0.12)。
■总而言之,肌少症之间存在正相关,所以,老年受试者的动脉僵硬度。特别是,较大的中央动脉僵硬度与SO相关,概述了对心血管风险状况的显着影响。
UNASSIGNED: Aging is associated with a higher prevalence of sarcopenia, sarcopenic obesity (SO), and increased arterial stiffening, with possible detrimental effects on morbidity and mortality. The aim of this study was to assess the relationships between sarcopenia, SO, and different indexes of arterial stiffness in older adults.
UNASSIGNED: A total of 77 hospitalized patients (mean age 78.68 ± 9.65 years) were evaluated, obtaining anthropometric variables, biochemical samples, handgrip test, and body composition assessment. Arterial stiffness was evaluated by measuring both carotid-femoral pulse wave velocity (cfPWV), a proxy for central stiffness, and cardio-ankle vascular index (CAVI), as well as considering peripheral arteries. The population was sorted into four subgroups: obese, sarcopenic, SO, and controls.
UNASSIGNED: The highest CAVI (11.31 ± 2.58) was found in sarcopenic patients. SO had the highest value of cfPWV (15.18 ± 8.44 m/s), even after adjustment for significant covariates. In multiple regressions, SO diagnosis resulted as a significant predictor of cfPWV (p = 0.03, R2 = 0.20), and sarcopenia diagnosis resulted as a predictor of CAVI (p = 0.042, R2 = 0.12).
UNASSIGNED: In conclusion, a positive correlation is found between sarcopenia, SO, and arterial stiffness among older subjects. In particular, greater central arterial stiffness is associated with SO, outlining a remarkable effect on the cardiovascular risk profile.