背景:冠心病(CHD)已成为世界性的公共卫生问题。遗传因素被认为是CHD的重要危险因素。本研究旨在探讨CYP4A22基因多态性与中国汉族人群冠心病易感性的相关性。
方法:我们使用SNPStats在线软件完成了962名志愿者的关联分析。假阳性报告概率分析用于确认阳性结果是否值得注意。Haploview软件和SNPStats用于单倍型分析和连锁不平衡。多因素降维用于评估候选SNP之间的相互作用。
结果:在总体和一些分层分析中(男性,年龄≤60岁或冠心病合并高血压患者),CYP4A22-rs12564525(总体,OR=0.83,p值为0.042)和CYP4A22-rs2056900(总体,OR=1.22,p值为0.032)与冠心病的风险相关。CYP4A22-4926581仅在一些分层分析中与CHD风险增加相关。FPRP表明,我们研究中的所有阳性结果都是值得注意的发现。此外,MDR表明,由rs2056900组成的单基因座模型是预测冠心病易感性的最佳模型。
结论:对CHD的易感性与CYP4A22rs12564525和rs2056900之间存在显著关联。
BACKGROUND: Coronary heart disease (CHD) has become a worldwide public health problem. Genetic factors are considered important risk factors for CHD. The aim of this study was to explore the correlation between
CYP4A22 gene polymorphism and CHD susceptibility in the Chinese Han population.
METHODS: We used SNPStats online software to complete the association analysis among 962 volunteers. False-positive report probability analysis was used to confirm whether a positive result is noteworthy. Haploview software and SNPStats were used for haplotype analysis and linkage disequilibrium. Multi-factor dimensionality reduction was applied to evaluate the interaction between candidate SNPs.
RESULTS: In overall and some stratified analyses (male, age ≤ 60 years or CHD patients complicated with hypertension),
CYP4A22-rs12564525 (overall, OR = 0.83, p-value is 0.042) and
CYP4A22-rs2056900 (overall, OR = 1.22, p-value is 0.032) were associated with the risk of CHD.
CYP4A22-4926581 was associated with increased CHD risk only in some stratified analyses. FPRP indicated that all positive results in our study are noteworthy findings. In addition, MDR showed that the single-locus model composed of rs2056900 is the best model for predicting susceptibility to CHD.
CONCLUSIONS: There are significant associations between susceptibility to CHD and
CYP4A22 rs12564525, and rs2056900.