■当前有关体力活动(PA)与心脏重塑之间关系的知识主要来自对运动员的横断面研究,在一般成年人和老年人群中,这种关联存在知识差距。因此,本研究的目的是探讨一般成人和老年人群的累积PA与心脏结构和功能变化之间的纵向关联.
■这项纵向研究包括来自Tromsø研究的第六次(Tromsø6,2007-08)和第七次(Tromsø7,2015-16)调查的594名参与者。在两个时间点通过超声心动图评估心脏结构和功能,PA在两个时间点通过问卷调查自我报告。PA体积表示为累积PA(低,中等,和硬),并使用ANCOVA评估与左心房(LA)和左心室(LV)结构和功能的关联。
■总的来说,从Tromsø6到Tromsø7,与中度PA(0.08cm/m2,95%CI0.01-0.15,p=0.020)相比,Hard的LA直径指数(LADi)显着增加更多。当按性别或年龄分层时,在男性和仅<65岁的参与者中,较高的累积PA水平与LADi增加相关.中度左心室指数(LVMi)的增加明显高于低PA(+3.9g/m2.7,95%CI0.23-7.57,p=0.037)。当按性别或年龄分层时,LVMi和指数LV直径(LVDi)的这些变化仅在女性中显著。在累积PA和相对壁厚变化之间没有观察到显著的关联。E/E比率,e速度,左心室射血分数,和LADi/LVDi比率。
■较高的累积PA水平与男性和<65岁参与者的LADi增加相关,女性的LVMi和LVDi增加。尽管心腔扩大,心脏的泵功能没有随着PA水平的升高而改变,房室比率不变。我们的结果表明,心腔扩大是对PA的生理反应。
UNASSIGNED: Current knowledge about the relationship between physical activity (PA) and cardiac remodeling is mainly derived from cross-sectional studies of athletes, and there is a knowledge gap of this association in the general adult and elderly population. Therefore, we aimed to explore the longitudinal association between cumulative PA and change in cardiac structure and function in a general adult and elderly population.
UNASSIGNED: This longitudinal study includes 594 participants from the sixth (Tromsø6, 2007-08) and seventh (Tromsø7, 2015-16) survey of the Tromsø Study. Cardiac structure and function were assessed by echocardiography at two time points, and PA was self-reported by questionnaire at both time points. PA volume was expressed as cumulative PA (Low, Moderate, and Hard) and the association with left atrial (LA) and left ventricular (LV) structure and function was assessed using ANCOVA.
UNASSIGNED: Overall, LA diameter index (LADi) increased significantly more in Hard compared to Moderate PA (+0.08 cm/m2, 95% CI 0.01-0.15, p = 0.020) from Tromsø6 to Tromsø7. When stratified by sex or age, higher levels of cumulative PA were associated with increased LADi in males and in participants <65 years only. Indexed LV mass (LVMi) increased significantly more in Moderate than in Low PA (+3.9 g/m2.7, 95% CI 0.23-7.57, p = 0.037). When stratified by sex or age, these changes in LVMi and indexed LV diameter (LVDi) were only significant in females. No significant associations were observed between cumulative PA and change in relative wall thickness, E/e\' ratio, e\' velocity, LV ejection fraction, and LADi/LVDi ratio.
UNASSIGNED: Higher levels of cumulative PA were associated with increased LADi in males and participants <65 years, and with increased LVMi and LVDi in females. Despite cardiac chamber enlargement, the pump function of the heart did not change with higher levels of PA, and the atrioventricular ratio was unchanged. Our results indicate that cardiac chamber enlargement is a physiological response to PA.