血液(血液)癌是血液和淋巴形成组织的癌症,其占所有癌症的约10%。据报道,所有血液癌症中约有60%是无法治愈的。尽管在检测/诊断方面有了实质性的改善,化疗和骨髓移植,仍然存在高复发和不可预测但明确定义的复发,表明仍然缺乏有效的治疗方法.在过去的二十年里,药用植物及其生物活性化合物正被用作治疗癌症的潜在药物和替代疗法。这是由于它们的抗氧化剂,抗炎,抗诱变,抗血管生成,抗癌活性和可忽略的副作用。这些生物活性化合物具有通过各种机制减少血液癌症增殖的能力,例如促进细胞凋亡。转录调节,抑制信号通路,下调受体和阻断细胞周期。这篇综述研究强调了九种生物活性化合物(槲皮素,熊果酸,Fisetin,白藜芦醇,表没食子儿茶素没食子酸酯,姜黄素,藤黄酸,butein和celastrol)作为血液癌症化学预防的潜在补救措施。该研究为使用来自植物的生物活性化合物化学预防血液癌症的有效性提供了有用的见解。
Haematological (blood) cancers are the cancers of the blood and lymphoid forming tissues which represents approximately 10% of all cancers. It has been reported that approximately 60% of all blood cancers are incurable. Despite substantial improvement in access to detection/diagnosis, chemotherapy and bone marrow transplantation, there is still high recurrence and unpredictable but clearly defined relapses indicating that effective therapies are still lacking. Over the past two decades, medicinal plants and their biologically active compounds are being used as potential remedies and alternative therapies for the treatment of cancer. This is due to their anti-oxidant, anti-inflammatory, anti-mutagenic, anti-angiogenic, anti-cancer activities and negligible side effects. These bioactive compounds have the capacity to reduce proliferation of haematological cancers via various mechanisms such as promoting apoptosis, transcription regulation, inhibition of signalling pathways, downregulating receptors and blocking cell cycle. This review study highlights the mechanistic and beneficial effects of nine bioactive compounds (quercetin, ursolic acid, fisetin, resveratrol, epigallocatechin gallate, curcumin, gambogic acid, butein and celastrol) as potential remedies for chemoprevention of haematological cancers. The study provides useful insights on the effectiveness of the use of bioactive compounds from plants for chemoprevention of haematological cancers.