■先前的研究强调了尿酸(UA)与肾素-血管紧张素-醛固酮系统(RAAS)活化之间的关联。然而,醛固酮,RAAS的最终产品,和UA相关的疾病仍然知之甚少。本研究旨在阐明醛固酮对高血压患者高尿酸血症和痛风的发展和进展的影响。
■我们的研究涉及34534名高血压参与者,评估血浆醛固酮浓度(PAC)在UA相关疾病中的作用,主要是高尿酸血症和痛风。我们应用多元逻辑回归来研究PAC的影响,并使用限制性立方样条(RCS)来检查PAC与这些疾病之间的剂量反应关系。为了获得更深入的见解,我们进行了阈值分析,进一步澄清这种关系的性质。最后,我们进行了亚组分析,以评估PAC在不同条件和不同亚组之间的作用。
■多因素logistic回归分析显示,高尿酸血症和痛风的发生与PAC水平的升高存在显著相关性。与第一四分位数(Q1)组相比,Q2、Q3和Q4组的发生风险均显著增加。此外,所进行的RCS分析显示出显著的非线性剂量反应关系,特别是当PAC大于14ng/dL时,高尿酸血症和痛风的风险进一步增加。最后,全面的亚组分析一致地加强了这些发现。
■这项研究表明,PAC水平升高与UA相关疾病的发展密切相关,即高尿酸血症和痛风,在高血压患者中。需要进一步的前瞻性研究来确认和验证这种关系。
UNASSIGNED: Prior research has highlighted the association between uric acid (UA) and the activation of the renin-angiotensin-
aldosterone system (RAAS). However, the specific relationship between
aldosterone, the RAAS\'s end product, and UA-related diseases remains poorly understood. This study aims to clarify the impact of
aldosterone on the development and progression of hyperuricemia and gout in hypertensive patients.
UNASSIGNED: Our study involved 34534 hypertensive participants, assessing plasma
aldosterone concentration (PAC)\'s role in UA-related diseases, mainly hyperuricemia and gout. We applied multiple logistic regression to investigate the impact of PAC and used restricted cubic splines (RCS) for examining the dose-response relationship between PAC and these diseases. To gain deeper insights, we conducted threshold analyses, further clarifying the nature of this relationship. Finally, we undertook subgroup analyses to evaluate PAC\'s effects across diverse conditions and among different subgroups.
UNASSIGNED: Multivariate logistic regression analysis revealed a significant correlation between the occurrence of hyperuricemia and gout and the elevation of PAC levels. Compared to the first quartile (Q1) group, groups Q2, Q3, and Q4 all exhibited a significantly increased risk of occurrence. Moreover, the conducted RCS analysis demonstrated a significant nonlinear dose-response relationship, especially when PAC was greater than 14 ng/dL, with a further increased risk of hyperuricemia and gout. Finally, comprehensive subgroup analyses consistently reinforced these findings.
UNASSIGNED: This study demonstrates a close association between elevated PAC levels and the development of UA-related diseases, namely hyperuricemia and gout, in hypertensive patients. Further prospective studies are warranted to confirm and validate this relationship.