■保持健康的血管结构和功能对于健康的怀孕很重要。肥胖是血管外科手术术后不良结局的众所周知的预测因子。然而,脉搏波速度(PWV)之间的关联,动脉僵硬度评估的公认参数,妊娠相关疾病仍不清楚。因此,我们进行了系统的审查,我们进行了荟萃分析以评估相关关联.
■我们系统地搜索了WebofScience和PubMed数据库,以获得在2023年4月之前发表的有关PWV和妊娠相关疾病的文章。使用带有标准偏差的平均值来评估有或没有相关疾病的孕妇的PWV差异。根据PWV的具体类型进行亚组分析。纽卡斯尔-渥太华量表用于评估纳入研究的质量。
■共纳入来自21项研究的6488名个体。所有入选的研究都是高质量的。总的来说,患有先兆子痫的孕妇PWV升高(平均差异(MD)=0.67,95%置信区间(CI):0.51,0.83,P<0.00001),高血压(MD=1.04,95%CI:1.00,1.08,P<0.00001),妊娠期糖尿病(MD=0.34,95CI:0.19,0.48,P<0.00001),和糖尿病(MD=0.49,95CI:0.27,0.70,P<0.00001)。基于特定类型的PWV的亚组分析显示出相似的结果。
■在我们的研究中,PWV在妊娠相关疾病中升高,包括先兆子痫,高血压,和糖尿病。PWV评估应被视为孕妇预防和管理妊娠期心血管疾病的临床常规。
UNASSIGNED: Maintaining healthy vascular structure and function is important for a healthy pregnancy. Obesity is a well-known predictor for poor postoperative outcomes of vascular surgery. However, the association between pulse wave velocity (PWV), a well-recognized parameter for arterial stiffness assessment, and pregnancy-associated diseases is still unclear. Therefore, we conducted this systematic review, and a meta-analysis was performed to assess the relevant associations.
UNASSIGNED: We systematically searched the Web of Science and PubMed databases to obtain articles on PWV and pregnancy-associated diseases published before April 2023. The mean with standard deviation was used to assess the differences in PWV in pregnant women with or without relevant diseases. Subgroup analysis was conducted according to specific types of PWV. The Newcastle‒Ottawa Scale was used to evaluate the quality of the enrolled studies.
UNASSIGNED: A total of 6488 individuals from 21 studies were included. All enrolled studies were high-quality. Overall, the PWV was elevated in pregnant women who suffered from preeclampsia (mean difference (MD) = 0.67, 95 % confidence interval (CI): 0.51,0.83, P < 0.00001), hypertension (MD = 1.04, 95 % CI: 1.00,1.08, P < 0.00001), gestational diabetes mellitus (MD = 0.34, 95%CI: 0.19,0.48, P < 0.00001), and diabetes (MD = 0.49, 95%CI: 0.27,0.70, P < 0.00001). Subgroup analysis based on specific types of PWV showed similar results.
UNASSIGNED: In our study, PWV is elevated in pregnancy-associated diseases, including preeclampsia, hypertension, and diabetes. The PWV assessment should be regarded as a clinical routine for pregnant women to prevent and manage cardiovascular diseases during pregnancy.