背景:急性A型主动脉夹层(AAD)患者入院收缩压(SBP)和住院死亡之间的证据不足。这里,我们研究了AAD患者SBP与院内死亡之间的关系.方法:选取2014年1月至2018年12月AAD患者703例。目标自变量和因变量为入院收缩压和住院死亡,分别。性别,年龄,体重指数(BMI),慢性肾功能不全,吸烟,高血压,糖尿病,实验室指标,和管理被用作协变量。结果:703名参与者的平均年龄为50.48±11.35。约76.24%的参与者是男性。在调整了混杂因素后,AAD患者入院SBP与住院死亡之间呈负相关(OR=0.88,95CI0.80-0.96).因此,在AAD患者的入院SBP和院内死亡之间检测到120点(mmHg)的非线性关系.拐点右侧(SBP>120mmHg)和左侧(SBP≤120mmHg)的置信区间和效应大小分别为0.96(0.85-1.09)和0.67(0.51-0.88),分别。根据亚组分析,男性人群和非糖尿病人群的变化更为明显。结论:AAD患者入院时SBP与院内病死率呈非线性关系。≤120mmHg时,SBP与住院死亡率呈负相关。
Background: Evidence between admission systolic blood pressure (SBP) and in-hospital deaths in acute type A aortic dissection (
AAD) patients is inadequate. Here, we examined the relationship between SBP and in-hospital deaths in
AAD patients. Methods: 703
AAD patients were enrolled from January 2014 to December 2018. The independent and dependent variables targeted were admission SBP and in-hospital deaths, respectively. Gender, age, body mass index (BMI), chronic renal insufficiency, smoking, hypertension, diabetes, laboratory indicators, and management were used as covariates. Results: The 703 participants had a mean age of 50.48 ± 11.35. About 76.24% of the participants were male. After adjusting for confounders, there was a negative correlation between
AAD patients\' admission SBP and in-hospital deaths (OR = 0.88, 95%CI 0.80-0.96). Consequently, a non-linear relationship of point 120 (mmHg) was detected between admission SBP and in-hospital deaths for AAD patients. Confidence intervals and effect sizes of the right (SBP >120 mmHg) and left (SBP ≤ 120 mmHg) sides of the inflection point were 0.96 (0.85-1.09) and 0.67 (0.51-0.88), respectively. The change in the male population and non-diabetes people was more pronounced according to subgroup analysis. Conclusions: Correlation between admission SBP and in-hospital mortality of
AAD patients is non-linear. SBP negatively correlated with in-hospital mortality when ≤120 mmHg.