背景:局部药物无法通过指甲板渗透给临床医生治疗甲癣带来了巨大挑战。此外,由于药物相互作用,口服药物并不适合所有患者,不利影响,和禁忌症。
目的:我们试图评估二氧化碳激光辅助局部治疗甲癣的临床疗效。
方法:总共,本研究包括75例经真菌学检查证实的356个甲癣指甲的患者。所有受影响的指甲每隔4周接受3次激光治疗,每天一次使用特比萘芬乳膏3个月。
结果:总而言之,94.66%和92%的治疗患者为氢氧化钾和培养阴性,分别,治疗3个月后。然而,只有84%和80%是氢氧化钾和培养阴性,分别,随访6个月。使用临床评分指标进行甲癣电子计算器,73.33%的患者得分高于6分,26.66%的患者得分低于6分。对得分超过6的患者进行了临床评估,其中98.18%的患者在3个月时对治疗有反应,其中78.18%的患者在随访6个月时对治疗有反应。
结论:缺乏对照组和随访时间短是局限性。
结论:发现部分二氧化碳激光治疗联合局部抗真菌治疗甲癣是有效的。然而,在临床上广泛使用之前,需要进行随机临床研究。
BACKGROUND: Inability of topical medications to penetrate via nail plate brings a great challenge to clinicians in treating onychomycosis. Furthermore, oral medications are not appropriate for all patients because of drug interactions, adverse effects, and contraindications.
OBJECTIVE: We sought to evaluate the clinical efficacy of fractional carbon-dioxide laser-assisted topical therapy for onychomycosis.
METHODS: In total, 75 patients with 356 onychomycotic nails confirmed by mycologic examination were included in this study. All the affected nails received 3 sessions of laser therapy at 4-week intervals and once-daily application of terbinafine cream for 3 months.
RESULTS: In all, 94.66% and 92% of the treated patients were potassium hydroxide and culture negative, respectively, after 3 months of treatment. However, only 84% and 80% were potassium hydroxide and culture negative, respectively, at 6 months of follow-up. Using Scoring Clinical Index for Onychomycosis electronic calculator, 73.33% of the patients scored higher than 6 and 26.66% of the patients scored 6 or less. Those who scored more than 6 were evaluated clinically and 98.18% of them showed response to treatment at 3 months and 78.18% of them at 6 months of follow-up.
CONCLUSIONS: Lack of control group and short duration of follow-up are limitations.
CONCLUSIONS: Fractional carbon-dioxide laser therapy combined with topical antifungal was found to be effective in the treatment of onychomycosis. However, randomized clinical studies are needed before it can be widely used in clinics.