背景:阴囊被认为是癣的罕见部位,因此缺乏关于临床特征的知识,阴囊癣的致病因子和皮肤微生物组的变化。
目的:我们试图分析临床特征,阴囊癣的致病因子和皮肤微生物组。
方法:在浙江省皮肤科门诊开展了一项双中心前瞻性观察研究,中国,从2017年9月到2019年9月。通过直接显微镜确认阴囊癣的诊断。收集临床和真菌学数据。分析阴囊癣患者的微生物群落组成,并与健康对照组进行比较。
结果:共纳入113例阴囊癣患者。阴囊癣表现为孤立性病变(9/113,8.0%)或伴有其他部位的癣(104/113,92.0%)。股癣101例(89.38%)。真菌培养阳性63例,其中红色毛癣菌生长60例(95.2%),石膏Nannizzia培养3例(4.8%)。与18例健康个体相比,18例患者阴囊病变中的皮肤微生物组显示毛癣菌丰度增加,而马拉色菌则减少。细菌多样性没有发现显著差异。
结论:阴囊癣常伴有其他皮肤部位的浅表真菌感染,股癣是最常见的疾病。而不是吉卜赛,红斑酵母是最常见的阴囊癣病原体。总的来说,阴囊癣表现出皮肤真菌群落的变化,毛癣菌增加,马拉色菌丰度降低。
BACKGROUND: The scrotum is considered as an uncommon site for tinea, hence there is a lack of knowledge about the clinical characteristics, pathogenic agents and the skin microbiome changes of tinea scrotum.
OBJECTIVE: We sought to analyze the clinical features, pathogenic agents and skin microbiome of tinea scrotum.
METHODS: A two-center prospective observational study was carried out in outpatient dermatology clinics in Zhejiang,
China, from September 2017 to September 2019. The diagnosis of tinea scrotum was confirmed by direct microscopy. Clinical and mycological data were collected. The composition of microbial communities of patients with tinea scrotum was analyzed and compared with healthy controls.
RESULTS: A total of 113 patients with tinea scrotum were included. Tinea scrotum was either presented with isolated lesions (9/113, 8.0%) or accompanied by tinea of other sites (104/113, 92.0%). Tinea cruris was detected in 101 cases (89.38%). Fungal culture was positive in 63 cases, among which Trichophyton rubrum was grown in 60 cases (95.2%) and Nannizzia gypsea was cultured in 3 cases (4.8%). The skin microbiome in scrotum lesions from 18 patients showed increased abundance of Trichophyton compared with 18 healthy individuals, while Malassezia was decreased. No significant difference in bacterial diversity was found.
CONCLUSIONS: Tinea scrotum was often companied by superficial fungal infections of other skin sites, with tinea cruris being the most common condition. Instead of N. gypsea, T. rubrum was the most frequently identified pathogen for tinea scrotum. In general, tinea scrotum exhibited changes in the fungal communities of the skin with increased Trichophyton and decreased Malassezia abundance.