size for gestational age

胎龄大小
  • 文章类型: Journal Article
    我们的目标是通过出生体重全面汇集自闭症谱系障碍(ASD)诊断的患病率,胎龄,和胎龄的大小。PubMed,EMBASE,WebofScience,OvidPsycINFO,和Cochrane图书馆在2021年12月22日之前进行了搜索。我们使用随机效应模型汇集数据,并使用I2统计量量化异质性。在最初确定的66643条记录中,75项研究纳入荟萃分析。ASD诊断的合并患病率估计如下:极低出生体重,3.1%(912名ASD/66,445人);低出生体重,2.3%(5672ASD/593,927人);正常出生体重,0.5%(17,361名ASD/2,378,933人);高出生体重,0.6%(4505ASD/430,699人);非常早产,2.8%(2113名ASD/128,513人);早产,2.1%(19672名ASD/1725244人);任期,0.6%(113,261ASD/15,297,259人);学期结束,0.6%(9419例ASD/1,138,215例);小于胎龄儿,1.9%(6314名ASD/796,550名个体);适合胎龄,0.7%(21,026名ASD/5,936,704人);胎龄较大,0.6%(2607名ASD/635,666人)。与参考患病率相比(正常出生体重的患病率,term,和适合胎龄的个体),极低出生体重的ASD诊断的患病率估计,低出生体重,非常早产,早产,小于胎龄个体显著增加,而那些高出生体重的人,学期结束后,胎龄大的个体没有显著变化.患病率估计存在地理差异。这项荟萃分析提供了按出生体重计算的ASD诊断患病率的可靠估计,胎龄,和胎龄的大小,并建议低出生体重(尤其是极低出生体重),早产(特别是非常早产),和小于胎龄的婴儿,而不是高出生体重,学期结束后,和胎龄较大的婴儿,与ASD诊断风险增加相关。然而,鉴于在大多数情况下显著的研究间异质性,由于原始文章中的信息有限,与ASD相关的某些重要混杂因素的未知影响,包括来自相对较少的国家的研究,本研究的结果应谨慎解释.
    We aimed to comprehensively pool the prevalence of autism spectrum disorder (ASD) diagnosis by birth weight, gestational age, and size for gestational age. PubMed, EMBASE, Web of Science, Ovid PsycINFO, and Cochrane Library were searched up to December 22, 2021. We pooled data using the random-effects model and quantified heterogeneity using the I2 statistic. Of 66 643 records initially identified, 75 studies were included in the meta-analysis. The pooled prevalence estimates of ASD diagnosis are as follows: very-low-birth weight, 3.1% (912 ASD/66,445 individuals); low-birth weight, 2.3% (5672 ASD/593,927 individuals); normal-birth weight, 0.5% (17,361 ASD/2,378,933 individuals); high-birth weight, 0.6% (4505 ASD/430,699 individuals); very preterm, 2.8% (2113 ASD/128,513 individuals); preterm, 2.1% (19 672 ASD/1 725 244 individuals); term, 0.6% (113,261 ASD/15,297,259 individuals); postterm, 0.6% (9419 ASD/1,138,215 individuals); small-for-gestational-age, 1.9% (6314 ASD/796,550 individuals); appropriate-for-gestational-age, 0.7% (21,026 ASD/5,936,704 individuals); and large-for-gestational-age, 0.6% (2607 ASD/635,666 individuals). Compared with the reference prevalence (those in normal-birth weight, term, and appropriate-for-gestational-age individuals), the prevalence estimates of ASD diagnosis in very-low-birth weight, low-birth weight, very preterm, preterm, and small-for-gestational-age individuals increased significantly, while those in high-birth weight, postterm, and large-for-gestational-age individuals did not change significantly. There were geographical differences in the prevalence estimates. This meta-analysis provided reliable estimates of the prevalence of ASD diagnosis by birth weight, gestational age, and size for gestational age, and suggested that low-birth weight (especially very-low-birth weight), preterm (especially very preterm), and small-for-gestational-age births, rather than high-birth weight, postterm, and large-for-gestational-age births, were associated with increased risk of ASD diagnosis. However, in view of marked between-study heterogeneity in most conditions, unknown effects of certain important confounders associated with ASD due to limited information in original articles, and included studies from a relatively small number of countries, the findings of this study should be interpreted with caution.
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