工作倦怠是一种受遗传和环境因素影响的压力相关综合征。睡眠质量差作为压力源可能导致工作倦怠。与应激反应性相关的催产素受体基因(OXTR)也可能对工作倦怠产生影响。我们旨在探讨睡眠质量的影响,功能性OXTRrs2268498多态性,以及他们在中国人群工作倦怠中的互动,这还没有被探索。
使用横截面设计进行了初步研究。从575名健康受试者中测量了匹兹堡睡眠质量指数(PSQI)和Malash倦怠量表(MBI)。在376名受试者中对OXTRrs2468498多态性进行了基因分型。
睡眠质量有显著的主效应(p<0.05),但不是OXTRrs2468498基因型的倦怠。有趣的是,睡眠质量与rs2468498基因型的交互作用显著(p<0.05)。在睡眠不佳的群体中,C等位基因(C/C和T/C)携带者的情绪耗竭水平高于T纯合子,在良好睡眠组,C等位基因携带者的情绪耗竭水平较低。
这项研究仅涵盖一所大学的受试者,基因分型的样本量相对较小。因为我们只分析了OXTRrs2268498多态性,这项研究无法揭示脑脊髓催产素浓度和单倍型的影响。
我们的研究结果表明,OXTR多态性调节主观睡眠质量对职业倦怠的影响。我们得出的结论是,OXTRrs2468498多态性的C等位基因在职业倦怠中起着易感作用。
Job burnout is a stress-related syndrome influenced by both genetic and environmental factors. Poor sleep quality acting as a stressor may lead to job burnout. The oxytocin receptor gene (OXTR) related to stress reactivity may also exert an effect on job burnout. We aimed to explore the effect of sleep quality, a functional OXTR
rs2268498 polymorphism, and their interaction on job burnout in the Chinese population, which has not been explored yet.
A preliminary study was performed using a cross-sectional design. The Pittsburgh Sleep Quality Index (PSQI) and the Malash Burnout Inventory (MBI) were measured from 575 healthy subjects. The OXTR rs2468498 polymorphism was genotyped in 376 subjects.
There were significant main effects of sleep quality (p<0.05), but not of the OXTR rs2468498 genotype on burnout. Interestingly, the interaction between sleep quality and the rs2468498 genotype was significant (p<0.05). In the poor sleep group, the C allele (C/C and T/C) carriers showed higher Emotional Exhaustion level than T homozygotes, while in the good sleep group, the C allele carrier showed a lower Emotional Exhaustion level.
This study covered subjects from only one university and the sample size for genotyping was relatively small. As we analyzed only the OXTR
rs2268498 polymorphism, this study could not reveal the effects of the cerebrospinal oxytocin concentration and the haplotypes.
Our findings suggest that the OXTR polymorphism modulates the influence of subjective sleep quality on burnout. We conclude that the C allele of the OXTR rs2468498 polymorphism plays a susceptible role in job burnout.