背景:肺功能评估对于慢性气道疾病(CADs)的早期筛查至关重要。然而,它仍未广泛用于流行病学或初级保健机构的早期诊断。因此,我们使用美国国家健康和营养调查(NHANES)的数据,探讨一般成人血清尿酸/血清肌酐(SUA/SCr)比值与肺功能之间的关系,以了解SUA/SCr在肺功能异常早期评估中的作用.
方法:从2007年到2012年NHANES,共有9569人被纳入我们的研究.使用回归模型,XGBoost算法模型,广义线性模型和两分段线性回归模型,研究了SUA/SCr比值与肺功能之间的联系.
结果:校正混杂变量后,数据显示,每增加一个单位的SUA/SCr比值,用力肺活量(FVC)下降47.630,一秒钟用力呼气量(FEV1)下降36.956.然而,SUA/SCr与FEV1/FVC无相关性.在FVC的XGBoost模型中,前五名最重要的是糖化血红蛋白,总胆红素,SUA/SCr,总胆固醇和天冬氨酸转氨酶,而在FEV1中,是糖化血红蛋白,总胆红素,总胆固醇,SUA/SCr和血清钙。此外,我们通过构建平滑曲线确定了SUA/SCr比值与FVC或FEV1之间的线性和负相关.
结论:在普通美国人口中,SUA/SCr比与FVC和FEV1成反比,但与FEV1/FVC无关,根据我们的研究。未来的研究应该调查SUA/SCr对肺功能的影响,并确定可能的作用机制。
Assessment of lung function is essential for the early screening chronic airway diseases (CADs). Nevertheless, it is still not widely used for early diagnosing CADs in epidemiological or primary care settings. Thus, we used data from the US National Health and Nutrition Examination Survey (NHANES) to discuss the relationship between the serum uric acid/serum creatinine (SUA/SCr) ratio and lung function in general adults to gain the role of SUA/SCr in early assessment of lung function abnormalities.
From 2007 to 2012 NHANES, a total of 9569 people were included in our study. Using the regression model, XGBoost algorithm model, generalised linear model and two-piecewise linear regression model, the link between the SUA/SCr ratio and lung function was investigated.
After correcting for confounding variables, the data revealed that forced vital capacity (FVC) declined by 47.630 and forced expiratory volume in one second (FEV1) decreased by 36.956 for each additional unit of SUA/SCr ratio. However, there was no association between SUA/SCr and FEV1/FVC. In the XGBoost model of FVC, the top five most important were glycohaemoglobin, total bilirubin, SUA/SCr, total cholesterol and aspartate aminotransferase, whereas in FEV1, were glycohaemoglobin, total bilirubin, total cholesterol, SUA/SCr and serum calcium. In addition, we determined the linear and inverse association between SUA/SCr ratio and FVC or FEV1 by constructing a smooth curve.
In the general American population, the SUA/SCr ratio is inversely linked with FVC and FEV1, but not with FEV1/FVC, according to our research. Future studies should investigate the impact of SUA/SCr on lung function and identify possible mechanisms of action.