未经证实:坏死性小肠结肠炎(NEC)是一种破坏性的胃肠道急症,具有显著的死亡率和发病率。一部分患者进展迅速,并在短时间内接受了手术干预。本研究旨在建立预测早产儿NEC快速进展的模型。
UNASSIGNED:2015年12月至2019年4月在广州市妇女儿童医疗中心进行了一项回顾性研究,以评估NEC新生儿。快速进展的NEC被定义为需要手术干预或在NEC发病48小时内死亡。患者分为两组:快速进行性NEC(RP-NEC)和非快速进行性NEC(nRP-NEC)。人口统计数据,围产期特征,考试变量,收集发病时的影像学检查结果。
UNASSIGNED:共216例NEC早产儿被纳入研究,其中64个有RP-NEC,152个有NRP-NEC。RP-NEC和nRP-NEC患者的死亡率分别为32.8%和3.28%,分别。男性(p值,调整后的赔率比[95%置信区间]:0.002,3.43[1.57,7.53]),门静脉气体(0.000,8.82[3.73,20.89]),中性粒细胞<2.0×109/L(0.005,4.44[1.59,12.43]),pH<7.3(7.2≤pH<7.3)(0.041,2.95[1.05,8.31]),NEC发病时pH<7.2(0.000,11.95[2.97,48.12])被确定为RP-NEC的独立危险因素。包括四个危险因素的已建立模型呈现0.801的曲线下面积,具有83%的特异性和66%的灵敏度。
未经证实:在患有NEC的早产儿中,在进展迅速的患者中观察到显著较高的死亡率.建议对这些患者进行密切监测,我们相信我们建立的模型可以有效地预测这种快速发展过程。
UNASSIGNED: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal emergency with significant mortality and morbidity rates. A subset of patients progressed rapidly and underwent surgical intervention within a short period. This study aimed to establish a model to predict the rapid progression of NEC in preterm neonates.
UNASSIGNED: A retrospective study was conducted to review neonates with NEC between December 2015 and April 2019 at the Guangzhou Women and Children\'s Medical Center. Rapidly progressive NEC was defined as the need for surgical intervention or death within 48 h of NEC onset. Patients were divided into two groups: rapidly progressive NEC (RP-NEC) and non-rapidly progressive NEC (nRP-NEC). Data on demographics, perinatal characteristics, examination variables, and radiographic findings at onset were collected.
UNASSIGNED: A total of 216 preterm neonates with NEC were included in the study, of which 64 had RP-NEC and 152 had nRP-NEC. The mortality rates of patients with RP-NEC and nRP-NEC were 32.8% and 3.28%, respectively. Male sex (p-value, adjusted odds ratio [95% confidence interval]: 0.002, 3.43 [1.57, 7.53]), portal venous gas (0.000, 8.82 [3.73, 20.89]), neutrophils <2.0 × 109/L (0.005, 4.44 [1.59, 12.43]), pH <7.3 (7.2 ≤ pH < 7.3) (0.041, 2.95 [1.05, 8.31]), and pH <7.2 (0.000, 11.95 [2.97, 48.12]) at NEC onset were identified as independent risk factors for RP-NEC. An established model that included the four risk factors presented an area under the curve of 0.801 with 83% specificity and 66% sensitivity.
UNASSIGNED: Among preterm neonates with NEC, a significantly higher mortality rate was observed in those with rapid progression. It is recommended that close surveillance be performed in these patients, and we are confident that our established model can efficiently predict this rapid progression course.