原发性胃肠道滤泡性淋巴瘤（PGI-FL）是一种罕见的结外淋巴瘤。其流行病学和预后仍不清楚。我们在监测中对1648例PGI-FL和34892例淋巴结FL（N-FL）的合格患者进行了回顾性分析，流行病学和最终结果(SEER)数据库。PGI-FL的年龄校正平均年发病率为0.111/100000。PGI-FL和N-FL患者的中位总生存期（OS）分别为207和165个月。5年弥漫性大B细胞淋巴瘤(DLBCL)的转化率分别为2.1%和2.6%。年龄,性别,grade,安阿伯舞台,原发部位和辐射是独立的预后因素(p<0.05)。列线图是为了预测1-，5年和10年OS和疾病特异性生存期（DSS）。接收器工作特性曲线和校准图表明，所建立的列线图具有强大而准确的性能。根据列线图评分将患者分为三个风险组。总之,PGI-FL的发病率在过去40年中有所增加，与N-FL相比，PGI-FL具有更好的预后和更低的DLBCL转化率。列线图被开发并验证为预测生存的个性化工具。将患者分为三个风险组，以协助临床医生识别高危患者并选择最佳的个体化治疗方法。
Primary gastrointestinal follicular lymphoma (PGI-FL) is a rare extra-nodal lymphoma. Its epidemiology and prognosis remain unclear. We performed a retrospective analysis of eligible patients with 1648 PGI-FL and 34 892 nodal FL (N-FL) in the Surveillance, Epidemiology and End Results (SEER) database. The age-adjusted average annual incidence of PGI-FL was 0.111/100000. The median overall survival (OS) for PGI-FL and N-FL patients was 207 and 165 months respectively. The 5-year diffuse large B-cell lymphoma (DLBCL) transformation rates were 2.1% and 2.6% respectively. Age, sex, grade, Ann Arbor stage, primary site and radiation were independent prognostic factors (p < 0.05). Nomograms were constructed to predict 1-, 5- and 10-year OS and disease-specific survival (DSS). The receiver operating characteristic curves and calibration plots showed the established nomograms had robust and accurate performance. Patients were classified into three risk groups according to nomogram score. In conclusion, the incidence of PGI-FL has increased over the past 40 years, and PGI-FL has a better prognosis and a lower DLBCL transformation rate than N-FL. The nomograms were developed and validated as an individualized tool to predict survival. Patients were divided into three risk groups to assist clinicians in identifying high-risk patients and choosing the optimal individualized treatments.
