physical inactivity

身体不活动
  • 文章类型: Editorial
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  • 文章类型: Journal Article
    目的:调查居住在疗养院的老年人缺乏体力活动的患病率,并通过使用能力来探索缺乏体力活动的决定因素,机会,动机-行为模型。
    方法:多点,采用方便抽样和问卷调查的方法进行横断面研究.
    方法:从2022年5月至2023年4月,从中国南方的三家养老院招募了390名养老院居民。参与者完成了自行设计的一般信息问卷,老年人身体活动量表,运动自我效能量表,锻炼福利量表,患者健康问卷-9和短体能电池测试。描述性统计,单变量分析,Spearman相关分析,并采用序数逻辑回归进行数据分析。
    结果:养老院居民缺乏体力活动的患病率达到88.46%。序数logistic回归结果显示,运动自我效能感,感知到的锻炼益处,物理功能,身体活动指导的可用性,有抑郁症,慢性病的数量和与配偶一起生活是缺乏体力活动的主要影响因素,并解释了63.7%的差异。
    结论:中国养老院居民缺乏体力活动是相当大的,受多种因素的影响。应根据这些因素设计和实施量身定制的措施,以增强体育锻炼,同时考虑中国文化的独特性。
    医疗保健专业人员应通过增加对福利的了解来增强居民的体育锻炼,提高自我效能感,改善身体机能,缓解抑郁,并将个性化身体活动指导纳入常规护理服务。应该更多地关注患有更多慢性病或没有与配偶生活在一起的居民。
    结论:缺乏运动是养老院居民的一个重要问题。了解身体不活动及其决定因素可以开发量身定制的干预措施,以提高他们的身体活动水平。
    本研究报告符合STROBE声明。
    招募符合纳入标准的疗养院居民。
    OBJECTIVE: To investigate the prevalence of physical inactivity in older adults living in nursing homes and explore the determinants of physical inactivity by using the Capability, Opportunity, Motivation-Behaviour model.
    METHODS: A multisite, cross-sectional study was performed by convenience sampling and questionnaire survey.
    METHODS: A total of 390 nursing home residents were recruited from three nursing homes in Southern China from May 2022 to April 2023. The participants completed a self-designed general information questionnaire, Physical Activity Scale for the Elderly, Self-Efficacy for Exercise Scale, Exercise Benefits Scale, Patient Health Questionnaire-9 and the Short Physical Performance Battery test. Descriptive statistics, univariate analysis, Spearman correlation analysis, and ordinal logistic regression were applied for data analysis.
    RESULTS: The prevalence of physical inactivity among the nursing home residents reached 88.46%. Ordinal logistic regression results showed that exercise self-efficacy, perceived exercise benefits, physical function, availability of physical activity instruction, having depression, number of chronic diseases and living with spouse were the main influencing determinants of physical inactivity and explained 63.7% of the variance.
    CONCLUSIONS: Physical inactivity was considerable in nursing home residents in China and influenced by complex factors. Tailored measures should be designed and implemented based on these factors to enhance physical activity while considering the uniqueness of Chinese culture.
    UNASSIGNED: Healthcare professionals should enhance physical activity of residents by increasing benefits understanding, boosting self-efficacy, improving physical function, alleviating depression and integrating personalized physical activity guidance into routine care services. And more attention should be paid to the residents who had more chronic diseases or did not live with spouse.
    CONCLUSIONS: Physical inactivity is a significant problem in nursing home residents. Understanding physical inactivity and its determinants enables the development of tailored interventions to enhance their physical activity level.
    UNASSIGNED: This study was reported conforming to the STROBE statement.
    UNASSIGNED: Nursing home residents who met the inclusion criteria were recruited.
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  • 文章类型: Journal Article
    背景:世界卫生组织提出,体力活动是提高人类生活质量、降低慢性非传染性疾病发生概率的有意义的方式,人类应该从体力活动促进健康的实际有效性转变为“体力活动使生活更有意义”的新观点。“体育素养的引入和发展揭示了体育活动在改善人类健康中的关键作用,以及人类在体育活动中的主动性对健康发展的重要性。因此,本文的目的是(1)对体育素养的文献进行文献计量分析,评估范围,频率,以及2015年至2023年来自各个国家和机构的研究出版物的地理分布;(2)可视化有关身体素养主题的文章中的关键词,以分析身体素养与健康之间是否存在联系,(3)基于可视化分析的结果,我们建议适当的健康建立在身体素养的基础上,进一步构建身体素养的循环路径,身体活动,和身体健康的改善。
    方法:本研究使用VOSviewer软件v.1.6.18,检索了2015年至2023年4月15日的WebofScience数据库的核心馆藏,以\"物理素养\"为关键词,探讨当前国际上对物理素养的研究。
    结果:共纳入3,446篇文章,并根据关键词的共现频率得出相关图,这表明身体素养与六个概念高度相关:健康素养,身体活动,健康,孩子们,青少年,和预防。
    结论:基于文献可视化技术的分析,身体素养和健康之间有很高的相关性,国际体育素养研究呈多点放大趋势,随着研究热点逐渐从体育领域转移到健康领域,并与健康领域密切相关,表明身体素养旨在通过推动人类增加身体活动来促进个人健康的实现。
    BACKGROUND: The World Health Organization has proposed that physical activity is a meaningful way to improve the quality of human life and reduce the probability of chronic non-communicable diseases and that humans should change their mindset from the actual effectiveness of physical activity in promoting health to the new view that \"physical activity makes life more meaningful.\" The introduction and development of physical literacy reveal the critical role of physical activity in improving human health and the importance of human initiative in physical activity for healthy development. Therefore, the objectives of this paper are (1) to conduct a bibliometric analysis of the literature on physical literacy, assessing the scope, frequency, and geographical distribution of research publications from various countries and institutions from 2015 to 2023; (2) to visualize keywords in articles on the topic of Physical literacy to analyze whether there is a link between physical literacy and health, and (3) based on the results of the visual analysis, we propose that proper health is built on the sense of physical literacy and further construct the circular path of physical literacy, physical activity, and physical health improvement.
    METHODS: Using VOSviewer software v.1.6.18, this study searched the core collection of the Web of Science database from 2015 to April 15, 2023, using \"physical literacy\" as a keyword to explore the current international research on physical literacy.
    RESULTS: A total of 3,446 articles were included, and a correlation map was derived based on the co-occurrence frequency of keywords, which showed that physical literacy was highly correlated with six concepts: health literacy, physical activity, health, children, adolescents, and prevention.
    CONCLUSIONS: Based on the analysis of literature visualization techniques, there is a high correlation between physical literacy and health, and international physical literacy research is in a trend of multi-point amplification, with research hotspots gradually shifting from the field of sports to the field of health and closely related to the field of health, indicating that physical literacy aims to promote the achievement of individual health by driving humans to increase physical activity.
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  • 文章类型: Journal Article
    目的:该研究旨在研究中等至剧烈的体育锻炼(MVPA)如何影响中国大学生抑郁症状的严重程度。此外,它试图分析涉及自我评估健康和一般自我效能感的中介机制。
    方法:本研究利用2023年中国大学生健康跟踪调查的数据,采用多元线性回归和结构方程建模技术,研究MVPA对大学生抑郁水平的影响及其潜在的中介机制。主要队列包括来自中国106所大学的49,717名注册大学生。
    结果:共收集了41,620份有效问卷(回复率:83.7%),女性占58.6%。在过去的一个月里,大约30.2%的大学生从事MVPA。自评健康(B=-0.282,P<0.001)和一般自我效能感(B=-0.133,P<0.001)显著影响大学生抑郁得分。即使在控制了其他变量之后,参与MVPA与抑郁评分降低仍然显著相关(B=-0.062,P=0.002).结构方程模型的结果表明,MVPA不仅直接降低了大学生的抑郁得分,而且通过改善大学生的身体健康状况和一般自我效能感间接降低了抑郁症发生的可能性。
    结论:中国大学生缺乏体育锻炼是显而易见的。参与MVPA可以降低大学生抑郁的可能性。MVPA通过提高大学生的一般自我效能感和改善他们的身体健康来实现这种降低。影响大学生抑郁水平的因素是多方面的。对于未来针对大学生心理健康的干预措施,应强调纳入行为和心理因素的综合方法。
    OBJECTIVE: The study aims to examine how moderate-to-vigorous physical activity (MVPA) affects the severity of depression symptoms among Chinese college students. Additionally, it seeks to analyze the mediating mechanisms involving self-rated health and general self-efficacy.
    METHODS: The study utilized data from the 2023 Chinese College Health Tracking Survey and employed multiple linear regression and structural equation modeling techniques to investigate the impacts of MVPA on depression levels and its underlying mediating mechanisms among college students. The primary cohort comprised 49,717 enrolled college students from 106 universities in China.
    RESULTS: A total of 41,620 valid questionnaires were collected (response rate: 83.7%), with females accounting for 58.6%. In the past month, approximately 30.2% of college students engaged in MVPA. Self-rated health (B = - 0.282, P < 0.001) and general self-efficacy (B = - 0.133, P < 0.001) significantly influenced college students\' depression scores. Even after controlling for other variables, participating in MVPA remained significantly associated with reduced depression scores (B = - 0.062, P = 0.002). The results of the structural equation model showed that MVPA not only directly decreased college students\' depression scores but also indirectly reduced the likelihood of depression occurrence by improving their physical health status and general self-efficacy.
    CONCLUSIONS: The lack of physical activity among Chinese college students is evident. Engaging in MVPA can reduce the likelihood of depression among college students. MVPA achieves this reduction by enhancing college students\' general self-efficacy and improving their physical health. The factors influencing depression levels among college students are multifaceted. For future interventions targeting college students\' mental health, comprehensive approaches that incorporate behavioral and psychological factors should be emphasized.
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  • 文章类型: Journal Article
    促进全面了解缺乏体力活动导致的2型糖尿病的全球趋势和负担。
    我们利用了有关死亡率的数据,残疾调整寿命年(DALYs),以及来自2019年全球疾病负担研究的年龄标准化死亡率(ASMR)和DALYs比率(ASDR),旨在评估1990年至2019年期间204个国家和地区缺乏体力活动对2型糖尿病患病率的影响.这种方法有助于分析不同年龄段的糖尿病负担,性别,和地区。为了确定2型糖尿病患病率的长期进展,我们计算了负担率的估计年度百分比变化(EAPC)。
    全球,在1990年至2019年期间,因缺乏体力活动而导致的2型糖尿病死亡人数和DALY增加了一倍以上。同时,ASMR和ASDR增加了,EAPC为0.26(95%CI:0.13-0.39)和0.84(95%CI:0.78-0.89),分别。截至2019年,缺乏体力活动的全球ASMR和ASDR分别为每100000人1.6(95%UI:0.8-2.7)和每100000人55.9(95%UI:27.2-97.6)。在全球范围内与缺乏体力活动相关的2型糖尿病负担中观察到了显著的差异。与较低的SDI国家相比,较高的社会人口指数(SDI)国家的ASDR和ASMR较低。最初,女性表现出高于男性的ASMR和ASDR,但是ASMR和ASDR中的这种性别差异近年来有所减少。与缺乏体力活动相关的死亡率和DALY率在不同年龄段呈现倒V型模式,主要影响老年人口。
    在1990年至2019年之间,与缺乏体力活动有关的2型糖尿病的全球负担明显增加,强调缺乏体力活动是这种疾病全球格局中一个关键的可变风险因素。这需要进行更多的研究,以探索导致不同国家和性别之间疾病负担水平不同的变量。此外,它呼吁制定旨在指导预防策略的公共卫生政策,促进早期检测,加强2型糖尿病的管理。
    UNASSIGNED: To promote a comprehensive understanding of global trends and burden of type 2 diabetes attributable to physical inactivity.
    UNASSIGNED: We utilized data regarding mortality, disability-adjusted life years (DALYs), as well as age-standardized mortality rates (ASMR) and DALYs rates (ASDR) derived from the global burden of disease study 2019 to evaluate the impact of physical inactivity on the prevalence of type 2 diabetes in 204 countries and territories over the period from 1990 to 2019. This method facilitated the analysis of the diabetes burden across different ages, genders, and regions. To determine the long-term progression of type 2 diabetes prevalence, we computed the estimated annual percentage change (EAPC) in burden rates.
    UNASSIGNED: Globally, the number of deaths and DALYs from type 2 diabetes due to physical inactivity more than doubled between 1990 and 2019. Concurrently, there was an increase in the ASMR and ASDR, with EAPC of 0.26 (95% CI: 0.13-0.39) and 0.84 (95% CI: 0.78-0.89), respectively. As of 2019, the global ASMR and ASDR for physical inactivity stood at 1.6 (95% UI: 0.8-2.7) per 100 000 and 55.9 (95% UI: 27.2-97.6) per 100 000, respectively. Notable disparities were observed in the type 2 diabetes burden associated with physical inactivity worldwide, with higher sociodemographic index (SDI) countries experiencing lower ASDR and ASMR compared to lower SDI countries. Initially, females exhibited higher ASMR and ASDR than males, but this gender disparity in ASMR and ASDR has lessened in recent years. The mortality and DALYs rates associated with physical inactivity exhibit an inverted V-shaped pattern across various age groups, predominantly affecting the elderly population.
    UNASSIGNED: Between 1990 and 2019, there was a marked rise in the worldwide burden of type 2 diabetes associated with physical inactivity, underscoring the role of physical inactivity as a key changeable risk factor in the global landscape of this disease. This necessitates additional research to explore the variables contributing to the varying levels of disease burden across different countries and between sexes. Furthermore, it calls for the formulation of public health policies aimed at guiding prevention tactics, promoting early detection, and enhancing the management of type 2 diabetes.
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  • 文章类型: Journal Article
    背景:证据表明2019年冠状病毒病(COVID-19)幸存者可能会经历COVID-19后遗症。尽管已经确定了COVID-19后遗症的各种危险因素,人们对久坐的生活方式是否是一个独立的危险因素知之甚少。
    方法:在这项回顾性队列研究中,4,850名参与者在2022年6月至8月期间自我报告了他们的COVID-19后遗症症状。久坐不动的生活方式,包括缺乏体力活动(<150分钟/周的中等至剧烈强度的体力活动)和长时间的久坐行为(≥10小时/天),在第五次COVID-19波被记录之前。进行Logistic回归分析,以确定久坐的生活方式与急性和急性后(持续≥2个月)COVID-19后遗症风险之间的关系。
    结果:共纳入1,443名COVID-19幸存者和2,962名非COVID-19对照。在COVID-19幸存者中,>80%和>40%自我报告急性和急性后COVID-19后遗症,分别。在急性期后,身体不活动的COVID-19幸存者患失眠的风险降低37%,而那些长期久坐的人有25%,67%,出现至少一种症状的风险增加117%,头晕,和“别针”的感觉,分别。对于急性期,长时间的久坐行为与更高的疲劳风险有关,“脑雾”,呼吸困难,肌肉疼痛,关节痛,头晕,和“别针”的感觉。值得注意的是,久坐的行为,而不是身体不活动,在急性期和急性期,都与严重的COVID-19后遗症风险较高相关。
    结论:长期久坐行为与急性和急性后COVID-19后遗症的高风险独立相关,而缺乏体力活动在COVID-19后遗症中起着相互矛盾的作用。
    BACKGROUND: Evidence suggests that coronavirus disease 2019 (COVID-19) survivors could experience COVID-19 sequelae. Although various risk factors for COVID-19 sequelae have been identified, little is known about whether a sedentary lifestyle is an independent risk factor.
    METHODS: In this retrospective cohort study, 4850 participants self-reported their COVID-19 sequelae symptoms between June and August 2022. A sedentary lifestyle included physical inactivity (<150 min/week of moderate-to-vigorous intensity physical activity) and prolonged sedentary behavior (≥10 h/day) before the fifth COVID-19 wave was recorded. Logistic regression analysis was performed to determine the relationships between sedentary lifestyle and risk of acute and post-acute (lasting ≥2 months) COVID-19 sequelae.
    RESULTS: A total of 1443 COVID-19 survivors and 2962 non-COVID-19 controls were included. Of the COVID-19 survivors, >80% and >40% self-reported acute and post-acute COVID-19 sequelae, respectively. In the post-acute phase, COVID-19 survivors who were physically inactive had a 37% lower risk of insomnia, whereas those with prolonged sedentary behavior had 25%, 67%, and 117% higher risks of at least one symptom, dizziness, and \"pins and needles\" sensation, respectively. For the acute phase, prolonged sedentary behavior was associated with a higher risk of fatigue, \"brain fog,\" dyspnea, muscle pain, joint pain, dizziness, and \"pins and needles\" sensation. Notably, sedentary behavior, rather than physical inactivity, was correlated with a higher risk of severe post-COVID-19 sequelae in both acute and post-acute phases.
    CONCLUSIONS: Prolonged sedentary behavior was independently associated with a higher risk of both acute and post-acute COVID-19 sequelae, whereas physical inactivity played contradictory roles in COVID-19 sequelae.
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  • 文章类型: Journal Article
    目的:调查香港幼儿缺乏体力活动的危险因素。
    方法:这项后续研究是2015年开始的一项名为“研究营养对生长的影响”(SING)的前瞻性队列研究的一部分。受试者是从香港随机选择的本地托儿所和幼儿园招募的。2016-2017年向家长发放了自我管理问卷,以收集以下信息:(i)社会经济背景;(ii)健康相关因素,包括出生时的妊娠,和儿童自出生以来住院;(iii)休闲活动的类型,包括在电子游戏和体育活动上花费的时间。
    结果:共收集了1681份应答。平日不运动的可能性更高,与女性有关,不是长子,自出生以来住院三次或更多次,并有身体不活跃的护理人员。同时,母亲失业/退休的孩子,每天在电子游戏上花费超过1小时的人身体不活动的可能性大大降低。同样,作为女性,作为第二胎或第三胎,有一个低体力活动水平的护理人员与周末缺乏体力活动的机会较高有关。
    结论:父母的支持在决定儿童的身体活动水平方面发挥着关键作用。应实施公共卫生政策,以促进基于家庭的体育活动。
    OBJECTIVE: To investigate the risk factors associated with physical inactivity of young children in Hong Kong.
    METHODS: This follow-up study was part of a prospective cohort study named Studying Impact of Nutrition on Growth (SING) initiated in 2015. Subjects were recruited from randomly selected local nurseries and kindergartens in Hong Kong. Self-administrated questionnaires were distributed to parents in 2016-2017 to collect information on: (i) socio-economic background; (ii) health-related factors, including gestation at time of birth, and hospitalisation of the child since birth; (iii) types of leisure activities, including time spent on electronic games and physical activity.
    RESULTS: A total of 1681 responses were collected. A higher likelihood of physical inactivity on weekdays was associated with being female, not being the firstborn, having been hospitalised three or more times since birth, and having physically inactive care givers. Meanwhile, children whose mother was unemployed/retired, and who spent more than 1 h on electronic games per day were significantly less likely to be physically inactive. Similarly, being female, being the secondborn or the thirdborn, and having a care giver with low physical activity level were associated with a higher chance of physical inactivity on weekends.
    CONCLUSIONS: Parental support could play a pivotal role in determining a child\'s physical activity level. Public health policies should be implemented to promote family-based physical activities.
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  • 文章类型: Journal Article
    目的:这项研究的目的是提高对中国身体活动(PA)和久坐行为(SB)政策的认识,并强调中国政策格局中的相关差距和机会。
    方法:进行文献和网络搜索以确定中国的国家PA和SB政策。我们评估了健康增强体育活动政策审计工具(HEPAPAT,版本2)包含在每个政策文件中,以及它们是否以及如何解决PA和SB政策的“基石”:PA和SB指南,目标,监视和监测,和公共教育计划。
    结果:我们发现了60个国家PA和SB政策,其中54只专注于PA,6只专注于PA和SB。在2002年至2021年期间,发布的政策数量迅速增加。总的来说,这些政策包括根据HEPAPAT成功推广PA的国家政策方法的所有17个关键要素。这些政策反映了一系列部门的参与,并涵盖了巴勒斯坦权力机构的目标,PA和SB的建议,与学校相关的PA的任务和建议,PA公共教育计划,以及PA和SB的监视和监视计划。
    结论:我们的研究结果表明,中国越来越关注PA和SB政策,这反映了政策制定者为解决PA不足和SB过高的健康负担所做的努力。中国政策中可能会更加强调SB,特别是在为人口SB设定具体目标方面。中国的政策制定者和其他相关公共卫生利益相关者也可以考虑制定或采用24小时运动指南,根据其他几个国家的最新趋势。作为整个系统促进健康的方法的一部分,应继续促进不同部门在制定和实施中国的PA和SB政策方面的合作和参与。
    The aims of this study were to advance knowledge on physical activity (PA) and sedentary behaviour (SB) policies in China and to highlight related gaps and opportunities in the Chinese policy landscape.
    Literature and web-based searches were performed to identify national PA and SB policies in China. We assessed which of the 17 elements of the Health-Enhancing Physical Activity Policy Audit Tool (HEPA PAT, version 2) are included in each of the policy documents and whether and how they address the \'cornerstones\' of PA and SB policy: PA and SB guidelines, targets, surveillance and monitoring, and public education programmes.
    We found 60 national PA and SB policies, of which 54 focused on PA only and 6 focused on both PA and SB. There was a rapid increase in the number of policies issued between 2002 and 2021. In totality, the policies include all 17 key elements for a successful national policy approach to PA promotion according to the HEPA PAT. The policies reflect engagement from a range of sectors and encompass PA targets, recommendations for PA and SB, mandates and recommendations for school-related PA, plans for public education on PA, and plans for surveillance and monitoring of PA and SB.
    Our findings demonstrate that there has been increasing focus on PA and SB policies in China, which reflects efforts by policymakers to address the health burden of insufficient PA and excessive SB. More emphasis may be placed on SB in Chinese policy, particularly in terms of setting specific targets for population SB. Policymakers and other relevant public health stakeholders in China could also consider developing or adopting the 24-hour movement guidelines, in accordance with recent trends in several other countries. Collaboration and involvement of different sectors in the development and implementation of Chinese PA and SB policies should continue to be facilitated as part of a whole-of-system approach to health promotion.
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  • 文章类型: Journal Article
    这项研究分析了2021年6月21日至8月31日在香港对中国成年人的多种健康风险行为进行的大规模调查研究的存档数据。此外,这项研究调查了参与者对与其行为相关的风险的看法,他们对采取健康行为的态度,以及COVID-19对其健康危险行为的影响。共有4605名至少有一种健康危险行为的参与者被纳入分析。结果显示,大约一半的参与者不知道非传染性疾病(NCDs)可能是由烟草使用等健康风险行为引起的。有害使用酒精,缺乏身体活动,和不健康的饮食。超过一半的参与者没有定期进行身体检查或在家中监测身体健康。由于COVID-19大流行,许多参与者更加关注自己的健康,但很少有人改变他们不健康的习惯或采取更健康的生活方式。在704名吸烟者中,60.9%的人没有意识到吸烟会增加将COVID-19传播给他人的风险。只有32.2%和11.9%的吸烟者有意戒烟,并减少了香烟消费,分别。此外,13.6%的人报告说他们的每日香烟消费量有所增加,78.8%的人在大流行期间改变了吸烟行为。医疗保健专业人员必须向公众宣传健康风险行为与非传染性疾病之间以及COVID-19与非传染性疾病之间的关系。政府应制定一项长期计划,以加强初级卫生保健系统,并应对非传染性疾病发病率上升带来的挑战。
    This study analyzed archived data from a previous large-scale survey study on multiple health-risk behaviors among Chinese adults in Hong Kong between 21 June and 31 August 2021. In addition, this study examined participants\' perceptions of the risks associated with their behaviors, their attitudes toward adopting healthy behaviors, and the impact of COVID-19 on their health-risk behaviors. A total of 4605 participants who had at least one health-risk behavior were included in the analysis. The results showed that about half of the participants were unaware that non-communicable diseases (NCDs) can be caused by health-risk behaviors such as tobacco use, harmful use of alcohol, physical inactivity, and an unhealthy diet. More than half of the participants did not have regular body checkups or monitor their physical health at home. Many participants paid more attention to their health due to the COVID-19 pandemic, but few made changes to their unhealthy habits or adopted a healthier lifestyle. Of the 704 smokers, 60.9% did not realize that smoking increases the risk of transmitting COVID-19 to others. Only 32.2% and 11.9% smokers had the intention to quit smoking and reduced their cigarette consumption, respectively. Additionally, 13.6% reported that their daily cigarette consumption had increased, and 78.8% changed their smoking behavior during the pandemic. Healthcare professionals must educate the public about the association between health-risk behaviors and NCDs and between COVID-19 and NCDs. The government should formulate a long-term plan to strengthen the primary healthcare system and address the challenges posed by the rising prevalence of NCDs.
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  • 文章类型: Randomized Controlled Trial
    尽管众所周知,体育锻炼对老年人的免疫细胞具有抗衰老作用,体力活动(PA)对久坐不动的成人肥胖患者过早免疫衰老的影响在很大程度上仍是未知的.这项初步研究旨在研究客观测量的身体行为和基于Fitbit手表的自由生活PA干预在久坐的肥胖成年人免疫细胞过早衰老中的作用。在横断面分析中招募了45名参与者,其中40人进一步参与了随机对照试验。我们发现,客观测量的中等强度PA与肥胖成人外周血单核细胞(PBMC)中p16INK4a和p21Cip1的表达呈独立和负相关;然而,实际年龄,身体质量指数,身体脂肪,最大耗氧量,光PA,久坐的行为,睡眠时间没有。更重要的是,12周的PA干预减轻了PBMC中p16INK4a水平的升高,尽管它对p21Cip1和衰老相关的分泌表型没有影响。一起来看,身体活动不足是免疫细胞过早衰老的独立决定因素,而12周的PA干预是缓解成人肥胖患者过早免疫衰老的有希望的策略。
    Despite the well-known senolytic effects of physical exercise on immune cells in older adults, the effect of physical activity (PA) on premature immune senescence in sedentary adults with obesity remains largely unknown. This pilot study aimed to investigate the role of objectively measured physical behaviors and Fitbit watch-based free-living PA intervention in premature senescence of immune cells in sedentary adults with obesity. Forty-five participants were recruited in the cross-sectional analysis, and forty of them further participated in the randomized controlled trial. We found that objectively measured moderate-vigorous PA was independently and inversely correlated with the expression of p16INK4a and p21Cip1 in the peripheral blood mononuclear cell (PBMCs) of adults with obesity; however, chronological age, body mass index, body fat, maximal oxygen consumption, light PA, sedentary behaviors, and sleep duration were not. More importantly, the 12-week PA intervention mitigated the elevated p16INK4a levels in PBMCs, though it showed no effect on p21Cip1 and senescence-associated secretory phenotypes. Taken together, physical inactivity is an independent determinant of premature senescence in immune cells, while the 12-week PA intervention is a promising strategy to alleviate premature immune senescence in adults with obesity.
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