分裂型人格障碍(SPD)在共有遗传学方面与精神分裂症有关,生物学标记和现象学特征。在目前的研究中,我们的目的是确定先前报道的精神分裂症患者与前肌功能连接(FC)的改变是否可以扩展到SPD患者.
从上海一所大学的4461名新生中招募了20名SPD受试者和19名健康对照者,并接受了MRI的静息状态扫描。所有参与者均通过中文版的分裂型人格问卷(SPQ)和中文版的症状自评量表(SCL-90)进行评估。使用基于种子的功能连接方法分析成像数据。
与对照相比,SPD受试者在双侧前突和对侧海马旁之间表现出降低的FC。在SPD组中,SPQ总分与右侧前突和左侧海马旁之间的FC呈负相关(r=-0.603,p=0.006);在左侧前突和右侧海马旁之间,可疑性的SPQ子量表得分与FC之间呈负趋势(r=-0.553,p=0.014);在奇数或奇数的SPQ子量表得分之间发现了正趋势。至于SCL-90的分数,SPD组的SCL-90疑似性亚量表评分与右侧前肌和左侧海马旁的FC呈相似的负趋势(r=-0.535,p=0.018).
我们的研究结果表明,前外侧和对侧海马旁之间的功能连通性降低可能在精神分裂症谱系障碍的病理生理中起关键作用。
Schizotypal personality disorder (SPD) is linked to schizophrenia in terms of shared genetics, biological markers and phenomenological characteristics. In the current study, we aimed to determine whether the previously reported altered functional connectivity (FC) with precuneus in patients with schizophrenia could be extended to individuals with SPD.
Twenty subjects with SPD and 19 healthy controls were recruited from 4461 freshmen at a university in Shanghai and received a resting-state scan of MRI. All participants were evaluated by the Chinese version of Schizotypal Personality Questionnaire (SPQ) and the Chinese version of Symptom Checklist (SCL-90). The imaging data were analysed using the seed-based functional connectivity method.
Compared with the controls, SPD subjects exhibited reduced FC between bilateral precuneus and contralateral
parahippocampus. In SPD group, SPQ total score was negatively correlated with FC between right precuneus and left
parahippocampus (r = -0.603, p = 0.006); there was a negative trend between SPQ subscale score of suspiciousness and FC between left precuneus and right
parahippocampus (r = -0.553, p = 0.014); and a positive trend was found between SPQ subscale score of odd or eccentric behaviour and FC between left precuneus and right superior temporal gyrus (r = 0.543, p = 0.016). As for the SCL-90 score, a similar negative trend was found between SCL-90 subscale score of suspiciousness and FC between right precuneus and left
parahippocampus (r = -0.535, p = 0.018) in SPD group.
Our findings suggest that the decreased functional connectivity between precuneus and contralateral
parahippocampus might play a key role in the pathophysiology of schizophrenia spectrum disorder.