■进行这项研究,以探讨不同阶段慢性背痛(CBP)患者疼痛基质功能变化的差异,并确定这些大脑变化是否与疼痛持续时间有关。
■在这项研究中,29名健康个体和54名CBP患者被招募。根据疼痛持续时间,25例(3~12个月)分为CBP-S组,29例(≥24个月)分为CBP-L组。所有受试者完成临床疼痛相关测量和功能磁共振成像(fMRI)扫描。此外,低频波动幅度(ALFF),功能连接(FC),并进行相关分析。
■与健康对照相比,CBP-L组患者左前肌ALFF显著降低.在FC分析中,CBP-S和CBP-L组患者在双侧眶额皮质(OFC)和左侧腹侧后脑岛的几个区域显示FC显著降低.此外,在成对组比较中,左超颗粒岛和OFC的概率区域之间的FC存在显着差异。相关分析结果表明,疼痛持续时间与这些脑功能变化有关,ANCOVA结果显示疼痛强度和疼痛干扰评分不影响FC分析结果.
■慢性疼痛患者在不同阶段的疼痛神经基质有不同的变化。此外,疼痛持续时间与大脑功能变化有关。
UNASSIGNED: This study was conducted to explore the differences in functional changes in the pain matrix in patients with chronic back pain (CBP) at different stages and identify whether these brain changes were related to the pain duration.
UNASSIGNED: In this study, 29 healthy individuals and 54 patients with CBP were recruited. According to the pain duration, 25 patients (3 to 12 months) were divided into the CBP-S group and 29 patients (≥ 24 months) were divided into the CBP-L group. All subjects completed clinical pain-related measurement and functional magnetic resonance imaging (fMRI) scans. Moreover, the amplitude of low-frequency fluctuation (ALFF), functional connectivity (FC), and correlation analysis were conducted in this study.
UNASSIGNED: Compared with healthy controls, patients in the CBP-L group showed significantly decreased ALFF in the left precuneus. In the FC analysis, patients in the CBP-S and CBP-L groups showed significantly decreased FC in several regions in the bilateral orbitofrontal cortices (OFC) and the left ventral posterior insula. Moreover, there were significant differences in the FC between the left hyper granular insula and the probabilistic area in OFC in pairwise group comparisons. The correlation analysis results demonstrated that pain duration was correlated with these functional brain changes, and the ANCOVA results revealed that pain intensity and pain interference scores did not affect the FC analysis results.
UNASSIGNED: There are different changes in the pain neural matrix in patients with chronic pain at different stages. Furthermore, the pain duration is related to brain functional changes.