糖尿病视网膜病变(DR)是糖尿病患者常见的并发症。视网膜的生理功能受水合状态的影响。我们旨在探讨水合状态与DR之间的关系。
使用2005-2008年国家健康和营养检查调查(NHANES)进行这项横断面研究。血清渗透压用于评估所有参与者的水合状态,并且仅对老年人评估计算的渗透压。评估DR及其严重程度,并将其分级为轻度非增生性视网膜病变,中度/重度非增生性视网膜病变,糖尿病视网膜病变的早期治疗研究方案和NHANES数字分级方案。SASOnDemandforAcademics使用完全调整的多变量逻辑回归模型。
在5220名美国40岁或以上的成年人中,与渗透压最低组相比,血清渗透压最高四分位数的参与者出现DR的几率较高(OR:1.371,95%CI:1.001~1.876).对于有DR的参与者,高血清渗透压组的中度/重度非增生性视网膜病变和增生性糖尿病性视网膜病变的校正OR(95%CI)为2.119(1.200-3.741)和7.001(3.175-15.438),分别。此外,在老年人中,较高的计算渗透压与DR发生率显著相关(OR:2.039,95%CI:1.305-3.186).
水合状态较低的成年人患DR的风险较高,中度/重度非增生性视网膜病变,和增殖性糖尿病视网膜病变。老年人脱水,按计算的渗透压分类,与较高的DR比率有关。两种方法的结果趋势一致。
Diabetic retinopathy (DR) is a common complication of diabetic patients. Retinal physiological function is affected by hydration status. We aimed to explore the association between hydration status and DR.
National Health and Nutrition Examination Survey (NHANES) 2005-2008 was used to perform this cross-sectional study. Serum
osmolality was used to assess hydration status for all participants and calculated
osmolality was evaluated for only older people. DR and its severity were evaluated and graded into mild non-proliferative retinopathy, moderate/severe non-proliferative retinopathy, and proliferative diabetic retinopathy by the Early Treatment for Diabetic Retinopathy Study protocol and NHANES Digital Grading Protocol. Fully adjusted multivariable logistic regression models were used by SAS OnDemand for Academics.
Among the 5,220 United States adults aged 40 or older, compared with the lowest
osmolality group, participants with the highest quartile of serum osmolarity had higher odds of DR (OR: 1.371, 95% CI: 1.001-1.876). For participants with DR, the adjusted OR (95 % CI) of moderate/severe non-proliferative retinopathy and proliferative diabetic retinopathy in the higher serum osmolarity group was 2.119 (1.200-3.741) and 7.001 (3.175-15.438), respectively. Furthermore, in older people, higher calculated osmolarity was significantly associated with increased occurrence of DR (OR: 2.039, 95% CI: 1.305-3.186).
Adults with lower hydration status had higher risk of DR, moderate/severe non-proliferative retinopathy, and proliferative diabetic retinopathy. Dehydration in older adults, classified by calculated
osmolality, is associated with a higher rate of DR. There was consistent trend in the results between the two methods.