■这是首例报道的胸腺瘤患者急性渗出性副肿瘤性多形卵黄样黄斑病变(AEPPVM),伴有重症肌无力(MG)和多发性肌炎。
■为了检查患有卵黄样眼底病变和胸腺瘤的患者眼部疾病的发病机制,MG,和基于临床表现的全身多发性肌炎,诊断,鉴别诊断,和基因检测以确定合适的治疗方案。
■我们描述了一位63岁的女性,她来到我们的三级医疗中心,有3个月的双眼视力下降的病史。同期眼底镜检查显示2.0×1.7毫米,unifocal,黄色,黄斑区圆形卵黄样病变,被多焦点包围,浅,视网膜下液的黄白色口袋。患者病史包括胸腺瘤合并胸腺切除术治疗,联合心包切除术和术后放疗(20年前),随后诊断为MG与可疑胸腺相关(15年前)。三年前,患者被诊断为副肿瘤综合征相关的多发性肌炎;1年前,她因疑似转移性肿瘤而接受胸膜增厚检查。
■在初次诊断后3个月的最近一次随访中,患者病情稳定,眼部或全身疾病无明显临床进展.
UNASSIGNED: This is the first reported case of acute exudative paraneoplastic polymorphous vitelliform maculopathy (AEPPVM) in a patient with thymoma, accompanied by myasthenia gravis (MG) and polymyositis.
UNASSIGNED: To examine the pathogenesis of ocular disease in a patient with yolk-like fundus lesions and thymoma, MG, and polymyositis throughout the body based on clinical manifestations, diagnosis, differential diagnosis, and genetic testing to determine the appropriate treatment course.
UNASSIGNED: We describe a 63-year-old woman who presented to our tertiary medical center with a 3-month history of reduced visual acuity in both eyes. Concurrent fundoscopy revealed a 2.0 × 1.7-mm, unifocal, yellow, round vitelliform lesion in the macular region, surrounded by multifocal, shallow, yellow-white pockets of subretinal fluid. The patient\'s medical history included thymoma with thymectomy treatment, combined with pericardiectomy and postoperative radiotherapy (20 years prior), followed by a diagnosis of MG with suspect thymic association (15 years prior). Three years prior, the patient had been diagnosed with polymyositis related to paraneoplastic syndrome; 1 year prior, she had been examined for pleural thickening due to suspected metastatic tumor.
UNASSIGNED: On her most recent follow-up visit at 3 months after initial diagnosis, the patient was stable with no clinically significant progression in ocular or systemic conditions.