目标:尽管是重症肌无力(MG)的突出特征,眼外肌(EOM)在临床研究中很少受到关注。这项研究的目的是使用飞行时间磁共振血管造影(TOF-MRA)检查MG和对照患者的EOM体积。
方法:使用TOF-MRA图像计算EOM体积(整体和个体直肌),并在MG患者(包括亚组)和对照组之间进行比较。检查了EOM体积与疾病持续时间之间的相关性。使用多元线性回归分析建立了选定参数的预测方程。
结果:MG患者的EOM体积低于对照组,特别是在MG患者的眼压(MG-O)。MG-O在EOM体积与疾病持续时间之间呈中度负相关。多元线性回归显示,疾病持续时间和EOM状态(眼瘫与否)占EOM体积的48.4%。
结论:MG患者表现出EOM萎缩,尤其是眼瘫和病程长的患者。
OBJECTIVE: Despite being a prominent feature of myasthenia gravis (MG), extraocular muscle (EOM) has received little attention in clinical research. The aim of this study was to examine EOM volume in patients with MG and controls using time-of-flight magnetic resonance angiography (TOF-MRA).
METHODS: EOM volumes (overall and individual rectus muscles) were calculated using TOF-MRA images and compared between MG patients (including subgroups) and controls. The correlation between EOM volume and disease duration was examined. Predictive equations for the selected parameters were developed using multiple linear regression analysis.
RESULTS: EOM volume was lower in MG patients than controls, especially in MG patients with
ophthalmoparesis (MG-O). MG-O exhibited a moderate negative correlation between EOM volume and disease duration. Multiple linear regression showed that disease duration and EOM status (
ophthalmoparesis or not) account for 48.4% of EOM volume.
CONCLUSIONS: Patients with MG show atrophy of the EOMs, especially those with
ophthalmoparesis and long disease duration.