■认知障碍是涉及多个领域的非沟通性脑积水（NCH）的常见临床症状，包括执行功能，工作记忆,视觉空间功能，语言,和注意。功能磁共振成像（fMRI）可用于获得有关局部大脑区域功能活动和多个大脑区域功能连接（FC）的信息。然而,对相关认知障碍的研究有限；此外，NCH合并认知障碍的病理生理机制尚不清楚.这里,我们旨在探索区域神经活动和FC的变化，以及认知障碍的机制，NCH患者。
■总的来说，使用迷你精神状态检查（MMSE）和fMRI评估了16例NCH患者和25例人口统计学匹配的健康对照（HCs）。区域同质性的变化(ReHo)，度中心性(DC)，并对两组的感兴趣区域FC进行分析。功能磁共振成像指标(ReHo，DC,和FC）和NCH患者的MMSE评分也进行了调查。
■与HC组相比，NCH组在左中央前和中央后回表现出显著较低的ReHo值，左内侧前额叶皮质（MPFC）的ReHo值明显更高。与HC组相比，NCH组的双侧MPFC中的DC值也显着更高。关于基于种子的FC，与HC组相比,NCH组MPFC显示右侧顶叶上回和中央回的FC值降低.此外，在NCH组中，MMSE评分与左侧MPFC的ReHo值和双侧MPFC的DC值呈显著负相关,而MMSE评分与FC值呈显著正相关。最后，NCH患者的区域神经活动和FC改变，并与认知障碍相关。这些结果促进了我们对NCH与认知障碍之间关联的病理生理机制的理解。
UNASSIGNED: Cognitive impairment is a frequent clinical symptom of non-communicating hydrocephalus (NCH) involving multiple domains, including executive function, working memory, visual-spatial function, language, and attention. Functional magnetic resonance imaging (fMRI) can be used to obtain information on functional activity in local brain areas and functional connectivity (FC) across multiple brain regions. However, studies on the associated cognitive impairment are limited; further, the pathophysiological mechanisms of NCH with cognitive impairment remain unclear. Here, we aimed to explore alterations in regional neural activity and FC, as well as the mechanisms of cognitive impairment, in patients with NCH.
UNASSIGNED: Overall, 16 patients with NCH and 25 demographically matched healthy controls (HCs) were assessed using the Mini-Mental State Examination (MMSE) and fMRI. Changes in regional homogeneity (ReHo), degree centrality (DC), and region of interest-based FC were analyzed in both groups. The relationship between fMRI metrics (ReHo, DC, and FC) and MMSE scores in patients with NCH was also investigated.
UNASSIGNED: Compared with the HC group, the NCH group exhibited significantly lower ReHo values in the left precentral and postcentral gyri, and significantly higher ReHo values in the left medial prefrontal cortex (MPFC). The NCH group also showed significantly higher DC values in the bilateral MPFC compared with the HC group. Regarding seed-based FC, the MPFC showed reduced FC values in the right superior parietal and postcentral gyrus in the NCH group compared with those in the HC group. Moreover, within the NCH group, MMSE scores were significantly negatively correlated with the ReHo value in the left MPFC and the DC value in the bilateral MPFC, whereas MMSE scores were significantly positively correlated with FC values. To conclude, regional neural activity and FC are altered in patients with NCH and are correlated with cognitive impairment. These results advance our understanding of the pathophysiological mechanisms underlying the association between NCH and cognitive impairment.
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