■这项研究描述了阿尔茨海默病（AD）患者的葡萄糖代谢和tau蛋白沉积分布，并使用18F-FDG和18F-AV1451正电子发射断层扫描/计算机断层扫描（PET/CT）评估了神经心理学表现与tau蛋白沉积或葡萄糖代谢之间的关系。
■本研究纳入了64例β-淀粉样蛋白阳性（Aβ+）AD患者和25例健康参与者。所有参与者均接受18F-FDG和18F-AV1451PET/CT检查。收集临床数据和神经心理学评分。AD患者分为轻度，中度,根据简易精神状态检查（MMSE）评分，重度组。FDG和AV1451PET图像的标准化摄取值比率（SUVR）均使用小脑疣作为参考进行计算。计算整个大脑皮层和每个大脑区域的SUVR。使用自动解剖图谱(AAL)和Brodmann区域获得感兴趣体积(VOI)。采用学生t检验进行SUVR的组间比较。以年龄和教育程度为协变量，以受试者间的方式计算SUVR与神经心理学评分之间的偏相关系数。
■轻度亚组显示颞顶叶皮质中葡萄糖代谢和tau蛋白聚集的减少。随着神经精神表现的下降，FDGPET上的SUVR逐渐降低，tauPET上的SUVR逐渐升高。葡萄糖代谢减少和tau蛋白沉积的区域首先出现在顶叶皮质，其次是颞叶和额叶皮层，先后。FDG和tauSUVR均与MMSE显着相关，蒙特利尔认知评估（MOCA）听觉语言学习测试（AVLT），波士顿命名测试（BNT），时钟绘制任务（CDT），和言语流畅性测试（VFT）（p<0.05）。FDGPET上的SUVR与日常生活活动能力（ADL）和汉密尔顿抑郁量表（HAMD）显着相关。tauSUVR与ADL或HAMD之间没有显着相关性。
■tau蛋白沉积的延伸与葡萄糖代谢减少的区域相似，但不完全一致。tau和FDGSUVR都与领域特异性模式的认知功能相关，与tauPET结果相比，FDGPET结果与神经心理功能更密切相关。
UNASSIGNED: This study characterizes glucose metabolism and tau protein deposition distribution in patients with Alzheimer\'s disease (AD) and to evaluate the relationships between neuropsychological performance and tau protein deposition or glucose metabolism using 18F-FDG and 18F-AV1451 positron emission tomography/computed tomography (PET/CT).
UNASSIGNED: Sixty-four patients with β-amyloid-positive (Aβ+) AD and twenty-five healthy participants were enrolled in this study. All participants underwent 18F-FDG and 18F-AV1451 PET/CT. Clinical data and neuropsychological scores were collected. Patients with AD were divided into mild, moderate, and severe groups according to mini-mental state examination (MMSE) scores. The standardized uptake value ratios (SUVRs) for both FDG and AV1451 PET images were calculated using the cerebellar vermis as reference. The SUVRs of the whole cerebral cortex and each brain region were calculated. The volume of interest (VOI) was obtained using automated anatomical atlas (AAL) and Brodmann regions. Student\'s t-test was used to perform intergroup comparisons of SUVR. The partial correlation coefficient between SUVR and neuropsychological scores was computed in an inter-subject manner using age and education as covariates.
UNASSIGNED: The mild subgroup showed a reduction in glucose metabolism and aggregation of tau protein in the temporoparietal cortex. With a decline in neuropsychiatric performance, the SUVR on FDG PET decreased and SUVR on tau PET increased gradually. The areas of glucose metabolism reduction and tau protein deposition appeared first in the parietal cortex, followed by the temporal and frontal cortex, successively. Both FDG and tau SUVRs significantly correlated with MMSE, Montreal cognitive assessment (MOCA), auditory verbal learning test (AVLT), Boston naming test (BNT), clock drawing task (CDT), and verbal fluency test (VFT) (p < 0.05). The SUVR on FDG PET significantly correlated with activities of daily living (ADL) and the Hamilton depression scale (HAMD). There was no significant correlation between the tau SUVRs and ADL or HAMD.
UNASSIGNED: The extension of tau protein deposition was similar but not exactly consistent with the area of glucose metabolism reduction. Both tau and FDG SUVRs correlated with cognitive function in domain-specific patterns, and the results of FDG PET more closely correlated with neuropsychological function than tau PET results did.
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