背景:脊髓中线电极阵列的偏离会影响意识障碍(DOC)患者C2-4颈脊髓刺激(SCS)的治疗效果。这项研究提出了一种新型的C2-3硬脑膜暴露程序的实施,并研究了其与传统手术相比的疗效。
方法:回顾性评估了69例以侧卧位接受SCS的DOC患者的手术和术后影像学数据。16例患者进行了C2-3硬脑膜暴露程序,其余患者进行了常规手术。比较了电极偏差的发生率,并调查了与偏差相关的因素。
结果:C2-3硬脑膜暴露组的电极完全中线覆盖率明显高于常规组(93.8%vs.54.7%,p=0.004)。C2-3之间硬脑膜的暴露是电极阵列完全中线覆盖的重要有利因素(比值比[OR]:0.091;95%置信区间[CI]:0.011-0.757;p=0.027)。位于C2椎骨下边缘上方≥5cm的电极是中线覆盖不完全的显著危险因素(OR:1.126;95%CI:1.016-1.248;p=0.023)。手术时间无差异,术中出血,或手术部位感染2组间观察。
结论:C2-3硬脑膜暴露程序,在侧卧位进行,是安全的,并且比传统手术具有更高的完全中线覆盖率。
BACKGROUND: Deviation of electrode array from the
midline of spinal cords affects the therapeutic outcomes of C2-4 cervical spinal cord stimulation (SCS) in patients with disorders of consciousness (DOC). This study proposed the implementation of a novel C2-3 dural exposure procedure and investigated its efficacy compared to conventional surgery.
METHODS: Surgical and postoperative imaging data from 69 patients with DOC who underwent SCS in the lateral decubitus position were retrospectively assessed. The C2-3 dural exposure procedure was performed in 16 patients while the rest underwent conventional surgery. The incidence of electrode deviation was compared, and factors associated with the deviation were investigated.
RESULTS: The rate of complete
midline coverage by the electrodes in the C2-3 dural exposure group was significantly higher than the conventional group (93.8% vs. 54.7%, p = 0.004). Exposure of the dura between C2-3 was a significant favorable factor for complete
midline coverage by the electrode array (odds ratio [OR]: 0.091; 95% confidence interval [CI]: 0.011-0.757; p = 0.027). Electrode positioned ≥5 cm above the lower edge of the C2 vertebra was a significant risk factor for incomplete
midline coverage (OR: 1.126; 95% CI: 1.016-1.248; p = 0.023). No difference in operation time, intraoperative bleeding, or surgical site infection was observed between the 2 groups.
CONCLUSIONS: The C2-3 dural exposure procedure, performed in the lateral decubitus position, was safe and had higher complete
midline coverage than conventional surgery.