■1064nm激光间质热疗法(LITT)广泛用于治疗癫痫和脑肿瘤;但是,没有数值模型可以通过仔细的体内验证来预测消融区域。
■在这项研究中,我们提出了一个模拟脑组织内传热的有限元方法系统的模型,辐射从施药器转移到脑组织,和组织损伤模型.
■为了加快实际应用的计算,通过与蒙特卡罗模拟的比较,我们还验证了P1近似是计算辐射传输的一种高效快速的方法。最后,我们在6例健康犬和8例癫痫患者体内验证了所提出的数值模型,发现预测的温度曲线和消融面积与磁共振成像测量结果非常吻合.
■我们的结果证明了该模型在预测1,064nmLITT的消融面积方面的可行性和可靠性,这对于使用LITT时的术前计划很重要。
UNASSIGNED: Laser interstitial thermal therapy (LITT) at 1064 nm is widely used to treat epilepsy and brain tumors; however, no numerical model exists that can predict the ablation region with careful in vivo validation.
UNASSIGNED: In this study, we proposed a model with a system of finite element methods simulating heat transfer inside the brain tissue, radiative transfer from the applicator into the brain tissue, and a model for tissue damage.
UNASSIGNED: To speed up the computation for practical applications, we also validated P1-approximation as an efficient and fast method for calculating radiative transfer by comparing it with Monte Carlo simulation. Finally, we validated the proposed numerical model in vivo on six healthy canines and eight human patients with epilepsy and found strong agreement between the predicted temperature profile and ablation area and the magnetic resonance imaging-measured results.
UNASSIGNED: Our results demonstrate the feasibility and reliability of the model in predicting the ablation area of 1,064 nm LITT, which is important for presurgical planning when using LITT.