目的：探讨顺铂注射液联合低温等离子射频消融术对晚期喉癌患者临床疗效及血清survivin水平的影响。
方法：选取我院2018年1月至2020年6月收治的42例局部晚期喉癌患者作为研究队列，根据每位患者的用药情况分为对照组（21例）和治疗组（21例）。对照组采用喉镜下CO2激光切除联合顺铂注射治疗,观察组患者采用低温等离子射频消融术联合顺铂注射治疗。观察两组临床疗效及WHOQOL-BREF评分,肿瘤标志物水平，比较血清survivin水平。
结果：治疗后，对照组的ORR和CBR分别为33.3%和61.9%，分别,显著低于观察组的66.7%和90.5%(P<0.05)。观察组的生理,心理,与社会关系维度得分显著高于对照组相应得分(P<0.05)。观察组血清肿瘤标志物CA72-4、CA19-9、SCC-Ag水平均低于对照组(P<0.05)。观察组血清survivin水平低于对照组(P<0.05)。结论顺铂注射联合低温等离子射频消融术治疗局部晚期喉癌疗效显著。它可以改善患者的生活质量，降低体内的肿瘤标志物水平，并抑制血清存活素水平。
OBJECTIVE: To investigate the effect of cisplatin injections combined with low-temperature plasma radiofrequency ablation on the clinical efficacy and serum survivin levels in advanced laryngeal cancer patients.
METHODS: A total of 42 patients with locally advanced laryngeal cancer treated in our hospital from January 2018 to June 2020 were recruited as the study cohort and placed in a control group (21 cases) or a treatment group (21 cases) according to the medication administered to each patient. The patients in the control group were treated with CO2 laser resections under laryngoscopy combined with cisplatin injections, and the patients in the observation group were treated with low-temperature plasma radiofrequency ablation combined with cisplatin injections. The clinical efficacies in the two groups were observed and the WHOQOL-BREF scores, tumor marker levels, and serum survivin levels were compared.
RESULTS: After the treatment, the ORR and CBR in the control group were 33.3% and 61.9%, respectively, levels that were significantly lower than the 66.7% and 90.5% in the observation group (P<0.05). The observation group\'s physiological, psychological, and social relations dimension scores were significantly higher than the corresponding scores in the control group (P<0.05). The tumor markers in the observation group were significantly lower in the serum CA72-4, CA19-9, and SCC-Ag levels than they were in the control group (P<0.05). The observation group exhibited lower serum survivin levels than the control group (P<0.05). Conclusion Cisplatin injections combined with low-temperature plasma radiofrequency ablation has a significant effect on the treatment of locally advanced laryngeal cancer. It can improve patients\' quality of life, reduce the tumor marker levels in the body, and inhibit the serum survivin levels.
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