GPCRs在增长中起着至关重要的作用,生物的发育和繁殖。在昆虫中,已经报道了大量的GPCRs用于全代谢,而不是半代谢。最近测序的豌豆蚜虫基因组为我们提供了分析半形虫中GPCRs的进化和潜在功能的机会。从具有代表性的半代谢昆虫Acyrthosiphonpisum模型中鉴定出82个GPCRs,其中37个有EST证据,和73是第一次注释。A.pisum之间的惊人差异,果蝇和栗树是A中激肽和SIFamide受体的重复。另一个分歧是在A.pisum中丢失了sulfakinin受体。这些重复/损失可能与渗透调节有关,A.pisum的繁殖和能量代谢。此外,这项工作将促进A.pisum中GPCRs的功能分析,并可能促进新的药物靶标的发现,以生物防治蚜虫。
GPCRs play crucial roles in the growth, development and reproduction of organisms. In insects, a large number of GPCRs have been reported for Holometabola but not Hemimetabola. The recently sequenced pea aphid genome provides us with the opportunity to analyze the evolution and potential functions of GPCRs in Hemimetabola. 82 GPCRs were identified from the representative model hemimetabolous insect Acyrthosiphon pisum, 37 of which have ESTs evidence, and 73 are annotated for the first time. A striking difference between A. pisum, Drosophila melanogaster and Tribolium castaneum is the duplication of the
kinin and SIFamide receptors in A. pisum. Another divergence is the loss of the sulfakinin receptor in A. pisum. These duplications/losses are likely involved in the osmoregulation, reproduction and energy metabolism of A. pisum. Moreover, this work will promote functional analyses of GPCRs in A. pisum and may advance new drug target discovery for biological control of the aphid.